Loeb, Lawrence A.

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

Cheng, K. C., Cahill, D. S., Kasai, H., Nishimura, S., & Loeb, L. A. (1992) · Journal of Biological Chemistry

DNA Repair MechanismsCarcinogens and Genotoxicity Assessment

Cited by 1,844

Detection of ultra-rare mutations by next-generation sequencing

Schmitt, M. W., Kennedy, S. R., Salk, J. J., Fox, E. J., Hiatt, J. B., & Loeb, L. A. (2012) · Proceedings of the National Academy of Sciences

Genomics and Phylogenetic StudiesGenomics and Rare Diseases

Cited by 1,047

Fidelity of HIV-1 reverse transcriptase

Preston, B. D., Poiesz, B. J., & Loeb, L. A. (1988) · Science

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 931

MUTAGENESIS BY APURINIC/APYRIMIDINIC SITES

Loeb, L. A., & Preston, B. D. (1986) · Annual Review of Genetics

DNA Repair MechanismsCarcinogens and Genotoxicity Assessment

Cited by 901

Detecting ultralow-frequency mutations by Duplex Sequencing

Kennedy, S. R., Schmitt, M. W., Fox, E. J., Kohrn, B. F., Salk, J. J., Ahn, E. H., Prindle, M. J., Kuong, K. J., Shen, J.-C., Risques, R.-A., et al. (2014) · Nature Protocols

Genomics and Phylogenetic StudiesCancer Genomics and Diagnostics

Cited by 503

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

Vermulst, M., Wanagat, J., Kujoth, G. C., Bielas, J. H., Rabinovitch, P. S., Prolla, T. A., & Loeb, L. A. (2008) · Nature Genetics

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 411

Mitochondrial point mutations do not limit the natural lifespan of mice

Vermulst, M., Bielas, J. H., Kujoth, G. C., Ladiges, W. C., Rabinovitch, P. S., Prolla, T. A., & Loeb, L. A. (2007) · Nature Genetics

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 404

Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage

Kennedy, S. R., Salk, J. J., Schmitt, M. W., & Loeb, L. A. (2013) · PLoS Genetics

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 363

Viral error catastrophe by mutagenic nucleosides

Anderson, J. P., Daifuku, R., & Loeb, L. A. (2004) · Annual Review of Microbiology

Evolution and Genetic DynamicsHepatitis C virus research

Cited by 221

Fidelity of Two Retroviral Reverse Transcriptases during DNA-Dependent DNA Synthesis In Vitro

Roberts, J. D., Preston, B. D., Johnston, L. A., Soni, A., Loeb, L. A., & Kunkel, T. A. (1989) · Molecular and Cellular Biology

Evolution and Genetic DynamicsDNA and Nucleic Acid Chemistry

Cited by 189

Nucleotide sequence preservation of human mitochondrial DNA.

Monnat, R. J., & Loeb, L. A. (1985) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyForensic and Genetic Research

Cited by 105

On the fidelity of DNA replication. Lack of exodeoxyribonuclease activity and error-correcting function in avian myeloblastosis virus DNA polymerase

Battula, N., & Loeb, L. A. (1976) · Journal of Biological Chemistry

DNA and Nucleic Acid ChemistryDNA Repair Mechanisms

Cited by 90

Optimization of DNA polymerase mutation rates during bacterial evolution

Loh, E., Salk, J. J., & Loeb, L. A. (2010) · Proceedings of the National Academy of Sciences

Evolution and Genetic DynamicsBacterial Genetics and Biotechnology

Cited by 81

Why Cockayne syndrome patients do not get cancer despite their DNA repair deficiency

Reid-Bayliss, K. S., Arron, S. T., Loeb, L. A., Bezrookove, V., & Cleaver, J. E. (2016) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsGenetic factors in colorectal cancer

Cited by 55