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A conditionally lethal yeast mutant blocked at the first step in glycosyl phosphatidylinositol anchor synthesis.
Open accessAbstract
Glycosyl phosphatidylinositols (GPIs) anchor many proteins to the surface of eukaryotic cells and may also serve as sorting signals on proteins and participate in signal transduction. We have isolated a Saccharomyces cerevisiae GPI anchoring mutant, gpi1, using a colony screen for cells blocked in [3H]inositol incorporation into protein. The gpi1 mutant is defective in vitro in the synthesis of N-acetylglucosaminyl phosphatidylinositol, the first intermediate in GPI synthesis, and is also temperature-sensitive for growth. Completion of the first step in GPI assembly is therefore required for growth of the unicellular eukaryote S. cerevisiae. GPI synthesis could therefore be exploited as a target for antifungal or antiparasitic agents.
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Cited by
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The Glycosylphosphatidylinositol Anchor: A Complex Membrane-Anchoring Structure for Proteins
Paulick, M. G., & Bertozzi, C. R. (2008) · Biochemistry · doi:10.1021/bi8006324 · Cited by 600
Peter, O., & Menon, A. K. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700002-jlr200 · Cited by 403
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Watanabe, N.-A., Miyazaki, M., Horii, T., Sagane, K., Tsukahara, K., & Hata, K. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00731-11 · Cited by 169
Metadata
- Authors
- Leidich, S. D., Drapp, D. A., & Orlean, P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1994-04
- Volume
- 269
- Issue
- 14
- Pages
- 10193-10196
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1564262044
- Cited by
- 178
- References
- 0
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Leidich, S. D., Drapp, D. A., & Orlean, P. (1994). A conditionally lethal yeast mutant blocked at the first step in glycosyl phosphatidylinositol anchor synthesis. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)34042-5
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