The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells.
Open accessAbstract
Transforming growth factor beta (TGF-beta) is a multifunctional polypeptide that regulates the proliferation and differentiation of various cells and has an angiogenic effect in vivo, although it inhibits the growth of cultured endothelial cells. We report here that TGF-beta treatment of quiescent cultures of mouse embryo-derived AKR-2B cells, which are growth-stimulated by TGF-beta, and human lung adenocarcinoma A549 cells, which are growth-inhibited by TGF-beta, results in the induction of vascular endothelial growth factor (VEGF) mRNA and protein. Maximal VEGF mRNA levels occurred 4-8 h after stimulation with a decline to background levels in 24 h. In contrast, the related placenta growth factor mRNA was not induced by TGF-beta in these cells. No VEGF receptor mRNA was seen in AKR-2B cells. Also, TGF-beta treatment of endothelial cells, which express the FLT1 and KDR/FLK-1 receptors for VEGF, did not cause VEGF induction. Because VEGF is known to be a strong angiogenic factor for endothelial cells, the results suggest that the angiogenic effect of TGF-beta on endothelial cells in blood vessels may be mediated at least partly by a paracrine induction of VEGF in other surrounding cell types.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Pro-angiogenic activities of TGF-β on endothelial cells are mediated by the ALK1 type I receptor and endoglin, which promote endothelial cell proliferation and migration265”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [265]
In the citing paper
“Various observations highlight activities of TGF-β on endothelial cells that may promote or repress angiogenesis, depending on the experimental setting264–266.”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [265]
Citations
Cites
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684
Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen
Leung, D. W., Cachianes, G., Kuang, W.-J., Goeddel, D. V., & Ferrara, N. (1989) · Science · doi:10.1126/science.2479986 · Cited by 5,000
Self-citationRoberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Heine, U., Liotta, L. A., Falanga, V., & Kehrl, J. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4167 · Cited by 2,867
Folkman, J., & Shing, Y. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49853-0 · Cited by 2,651
Plate, K. H., Breier, G., Weich, H. A., & Risau, W. (1992) · Nature · doi:10.1038/359845a0 · Cited by 2,262
Fort, P., Marty, L., Piechaczyk, M., Sabrouty, S. R.-E., Dani, C., Jeanteur, P., & Blanchard, J. (1985) · Nucleic Acids Research · doi:10.1093/nar/13.5.1431 · Cited by 2,072
Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF
Keck, P. J., Hauser, S. D., Krivi, G. G., Sanzo, K., Warren, T. G., Feder, J., & Connolly, D. T. (1989) · Science · doi:10.1126/science.2479987 · Cited by 2,058
The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor
de Vries, C. J. M., Escobedo, J. A., Ueno, H., Houck, K. A., Ferrara, N., & Williams, L. T. (1992) · Science · doi:10.1126/science.1312256 · Cited by 2,019
Self-citationTischer, E., Mitchell, R., Hartman, T., Silva, M., Gospodarowicz, D., Fiddes, J. C., & Abraham, J. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99049-6 · Cited by 1,988
Millauer, B., Wizigmann-Voos, S., Schnürch, H., Martínez, R., Møller, N. P. H., Risau, W., & Ullrich, A. (1993) · Cell · doi:10.1016/0092-8674(93)90573-9 · Cited by 1,927
Research works printed but not linked: 2
- Moses, 1985, Cancer Cells (Cold Spring Harbor), 3, 65
- Pertovaara, 1989, Mol. Cell. Biol., 9, 1255
Cited by
Sorted by citations
Items 601–691 of 691
Tumor Stroma Formation in Lung Cancer
Vignaud, J.-M., Marie, B., Picard, E., Nabil, K., Siat, J., Galateau-Sallé, F., Borrelly, J., Martinet, Y., & Martinet, N. (1998) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8924-7_7 · Cited by 1
Angiogenesis and angioregression gene expression analyses in swine corpus luteum
Ribeiro, L. D. A. (2007) · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna) · doi:10.6092/unibo/amsdottorato/428 · Cited by 1
Cancer-Associated Fibroblasts and the Role of TGF-β
Micke, P., Moustakas, A., Ohshima, M., & Kappert, K. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-293-9_27 · Cited by 1
Sterzyńska, K., Sujka‐Kordowska, P., & Witkiewicz, W. (2011) · Postepy Biologii Komorki · doi:10.2478/v10052-011-0004-3 · Cited by 1
EFFECT OF ZINC OXIDE NANOPARTICLES ON NEUROBLASTOMA SH-SY5Y CELLS
Zheng (2014) · American journal of biochemistry & biotechnology/American journal of biochemistry and biotechnology · doi:10.3844/ajbbsp.2014.116.124 · Cited by 1
Yamasaki, E., Soma, Y., Nakamura, M., Kawa, Y., & Mizoguchi, M. (2004) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2004.07.010 · Cited by 1
TGF-β and HER2/ErbB2 and Breast Cancer Progression
Todorović‐Raković, N. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-293-9_10 · Cited by 1
The Effects of Yacon (Smallanthus sonchifolius) Extract on Pancreatic Fibrosis in the Rat
Choi, N. H., Kim, J.-B., Kim, J.-T., & Park, I.-S. (2012) · Journal of Life Science · doi:10.5352/jls.2012.22.7.904 · Cited by 1
Transforming growth factor-β and skeletal homeostasis
Xu, X., & Cao, X. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00047-6 · Cited by 1
VEGF Signaling in Normal and Tumor Angiogenesis
Pardali, E., Godfrey, R., & Waltenberger, J. L. (2013) · CRC Press eBooks · doi:10.1201/b14842-2 · Cited by 1
Angiogenesis and Lymphangiogenesis in Peritoneal Dialysis
Gónzalez-Mateo, G. T., Pascual‐Antón, L., Carrasco, L. Á., Martínez, V., Fernández, I., Selgas, R., López‐Cabrera, M., & Aguilera, A. I. (2018) · InTech eBooks · doi:10.5772/intechopen.74015 · Cited by 1
Mechanisms of Cardiovascular Development
Rodgers, L. (2009) · UA Campus Repository (The University of Arizona) · Cited by 1
Role of Stat3 in Regulating HIF-1alpha Expression and Tumor Angiogenesis
Briggs, J. (2005) · Digital Commons - University of South Florida (University of South Florida) · Cited by 1
Gupta, S., Joshi, K., Wig, J. D., & Arora, S. K. (2009) · American Journal of Biomedical Sciences · doi:10.5099/aj090200157 · Cited by 1
Hall, Z. (2003) · Thorax · doi:10.1136/thorax.58.4.332 · Cited by 1
Interesting News in Peritoneal Dialysis
Vriese, A. S. D. (2002) · The Nephron journals/Nephron journals · doi:10.1159/000065443 · Cited by 1
Vascular endothelial growth factors and their receptors in embryos, adults and in tumors
Lymboussaki, A. (1999) · Työväentutkimus Vuosikirja · Cited by 1
Studies of Lipoxygenase Function
McCabe, N. P. (2005) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 1
Regulation of Angiogenesis by TGF-β Superfamily
Yamashita, H., Shimizu, A., Kato, M., Nishitoh, H., Ichijo, H., & Miyazono, K. (1997) · Springer eBooks · doi:10.1007/978-1-4612-1874-6_34 · Cited by 1
Molecular Analysis of Vascular Development and Disorders
Carmeliet, P., & Collen, D. (1999) · Developments in cardiovascular medicine · doi:10.1007/978-94-015-9321-2_18 · Cited by 1
Functional characterization of the PlGF-2 heparin-binding domain
Hoffmann, D. C. (2011) · Kölner Universitäts PublikationsServer (Universität zu Köln) · Cited by 1
Aberrant type I and type III collagen gene expression in human breast cancerin vivo
Kauppila, S., Stenbäck, F., Risteli, J., Jukkola, A., & Risteli, L. (1998) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(1998110)186:3
La, E., Muga, S. J., Locniskar, M. F., & Fischer, S. M. (1999) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199904)24:4 · Cited by 30
München, L.-M.-U., & Pohl, U. (2013)
TGF-β Signaling in Homeostasis and Cancer
Seoane, J. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-292-2_2
The vascular endothelial cell growth factor family and its receptors:
Gospodarowicz, D. (1996) · Growth factors and cytokines in health and disease · doi:10.1016/s1874-5687(96)80018-8
Damar Oluşum Fizyolojisi ve Vasküler Endotelyal Büyüme Faktörü
Güzel, D. (2015) · DergiPark (Istanbul University)
Chapter 9 biology of prostate cancer bone marrow metastasis
Nemeth, J. A., & Cher, M. L. (1999) · Advances in oncobiology/Advances in oncobiology (Print) · doi:10.1016/s1569-254x(99)80010-7
The role of transforming growth factor h 1 in the vascular system
Ghosh, J., Murphy, M. O., Turner, N. J., Khwaja, N., Halka, A., Kielty, C. M., & Walker, M. G. (2005)
The role of AMP-activated protein kinase in endothelial VEGF signalling
Reihill, J. A. (2009) · Enlighten: Theses (The University of Glasgow)
Targeted Therapy For Breast Cancer
Atieh, D. M., & Vahdat, L. T. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-337-0_14
Hollenberg, S. M. (2007) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-18132
Die Rolle des VEGF im Ovarialkarzinom
Bremert, A. (2011) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-9496
Role of TGF-β in Tumor Protection and Antitumor Immunity
Bollard, C. M., & Rooney, C. M. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-293-9_25
Martín, C., & del Pilar, M. (2003) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Le VEGF en physiologie et pathologie thyroïdienne
Klein, M., & Catargi, B. (2007) · Annales d Endocrinologie · doi:10.1016/j.ando.2007.09.005
Joussen, A. M., Adamis, A. P., & Kirchhof, B. (2000) · Spektrum der Augenheilkunde · doi:10.1007/bf03162830
Guo, K. (2008) · UA Campus Repository (The University of Arizona)
Pathophysiology and Clinical Implications of Vascular Endothelial Growth Factor
Ferrara, N. (2007) · Springer eBooks · doi:10.1007/978-3-540-33177-3_5
Self-citationMaharaj, A. S. R., & D'Amore, P. A. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-184-0_14
Olivier, A. K. (2010) · Iowa State University Digital Repository (Iowa State University) · doi:10.31274/etd-180810-769
The Role of Angiopoietin-2 in Signaling Through the Endothelial Receptor Tyrosine Kinase Tie1
Otvos, B. I. (2010) · DukeSpace (Duke University)
Effects of sex steroids and tamoxifen on VEGF in the breast
Garvin, S. (2006) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
INTERACTIONS OF SMALL LATENT TRANSFORMING GROWTH FACTOR-BETAS WITH THEIR BINDING PROTEINS, LTBPs
Saharinen, J. (2000) · Työväentutkimus Vuosikirja
Review Hypoxia Hypoxia in the pathogenesis of systemic sclerosis
Beyer, C., Schett, G. A., Distler, O., & Distler, J. H. W. (2009)
Appelmann, I., Liersch, R., Keßler, T., Mesters, R. M., & Berdel, W. E. (2010)
MICRORNA INVOLVEMENT IN COLON CANCER PROGRESSION
Sokolova, V. (2012) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/sokolova-viktorija_phd2012
Ranibizumab in Circulatory Disorder of Retinal Vein: an Evidence-based Approach
Shahsuvaryan, M. L. (2012)
TGFβ Receptor Signaling in Cancer and Metastasis
Oft, M. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48399-8_9
The Genetics of Pancreatic Cancer Progression
Iacobuzio–Donahue, C. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6549-2_8
Molecular mechanisms of lymphangiogenesis: role of VEGFR-3 mediated signaling
Mäkinen, T. (2002) · Työväentutkimus Vuosikirja
Associations among Emdogain®, human oral carcinoma cells and oral proteolytic enzymes
Laaksonen, M. (2010) · Työväentutkimus Vuosikirja
Lassus, P. (2002) · Työväentutkimus Vuosikirja
Fakultet, M. (2006)
Barbick, J. E. (2009) · Rice Research Repository (Rice University)
BILAN DES CONNAISSANCES ACTUELLES SUR LA CICATRISATION DES PLAIES CUTANÉES CHEZ LE CHIEN ET LE CHAT
Meynaud, M. P., & Autefage, M. A. (2006)
Le gel d'aloe vera en usage topique et ses vertus cicatrisantes
Roullier, M. (2015) · HAL
Sharma, B. (2013) · Sycamore Scholars (Indiana State University)
Tipping the balance from angiogenesis to fibrosis
Ballermann, B. J., & Obeidat, M. (2014)
Trebec‐Reynolds, D. P. (2010) · TSpace (University of Toronto)
Wartiovaara, U. (1999) · Työväentutkimus Vuosikirja
Growth Factors in the Human Preterm Lung
Lassus, P. (2002)
Tremmel, M. (2009) · heiDOK (Heidelberg University) · doi:10.11588/heidok.00009814
Vascular Endothelial Growth Factor in the Aqueous Humor of Dogs With and Without Intraocular Disease
Sandberg, C. (2009) · VTechWorks (Virginia Tech)
Molecular Basis for Vascular Endothelial Growth Factor Expression in Tumor
Xie, K., & Yao, J. C. (2008) · Springer eBooks · doi:10.1007/978-1-4020-8341-9_6
Pulmonary Hypertension in Idiopathic Interstitial Pneumonias
Bax, S., Wells, A. U., Price, L., & Wort, J. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-49918-5_6
A model of NSCLC microenvironment predicts optimal receptor targets
Han, C., & Wu, Y. (2019) · Quantitative Biology · doi:10.1007/s40484-019-0171-z
Transforming growth factor-beta in pleural fibrosis
Lee, Y. J. (2002) · UWA Profiles and Research Repository (University of Western Australia) · doi:10.26182/5d538c2cfbb40
Pathogenesis and Treatment of Keloids
Tosa, M., & Ogawa, R. (2020) · Nihon Ika Daigaku Igakkai Zasshi · doi:10.1272/manms.16.8
Role of TGF-β signaling in carcinoma cell migration and tumor progression
Matise, L. A. (2012)
TGFβ Signaling in Head and Neck Cancer Development and Metastases
Malkoski, S. P., Lighthall, J. G., & Wang, X.-J. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0775-2_8
(1997) · Elsevier eBooks · doi:10.1016/b978-012639875-5/50017-0
Paleolog, E. M., & Miotla, J. M. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-126-8_9
Pihlajaniemi, T. A., & Heljäsvaara, R. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726121845.793560503
Harada, K. (1998) · Scandinavian Journal of Rheumatology · doi:10.1080/03009749850154438
A comparative study of the PRF mediated cellular reaction of tumour cells
Parkhoo, K. (2024) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.87557
Nilsson, U. W. (2007) · DiVA (Linkoping University)
Supresión de la angiogénesis tumoral a través de anticuerpos monoclonales
Góngora, A. (2010) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)
Rol del factor de crecimiento transformante beta en la progresión del cáncer de pulmón
Carlini, M. J. (2013) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)
[Rôle du sytème calpaïne /calpastatine dans le remodelage cardiovasculaire]
Wan, F. (2013) · theses.fr (ABES) · doi:10.70675/0acbfc23zb828z4eb7z9d70z11fb0ac18fce
Le syndrome de Rendu-Osler-Weber : aspects génétiques, moléculaires et épidémiologiques
Din, F. A. E. (2015) · theses.fr (ABES) · doi:10.70675/2bea4075z05b5z47d5zbbd3z3f6caf32edd8
TGF-β Signaling and Vascular Morphogenesis
Pardali, E., Liu, Z., Scharpfenecker, M., & ten Dijke, P. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-293-9_31
Role of VEGF-C in Proliferation and Migration in a Cancer Model
Benke, E. M. (2008) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/w69w-vw28
He, H. (1999) · Victoria University Research Repository (Victoria University)
Blume, L.-F. (2010) · Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universität zu Kiel (Christian-Albrechts-Universität zu Kiel)
TGF-beta signaling in carcinogenic transformation of breast epithelial cells, using proteomics
Bhaskaran, N. (2008) · Figshare
Metadata
- Authors
- Pertovaara, L., Kaipainen, A., Mustonen, T., Orpana, A., Ferrara, N., Saksela, O., & Alitalo, K.
- Affiliations
- University of Helsinki (FI)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1994-03
- Volume
- 269
- Issue
- 9
- Pages
- 6271-6274
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1494416455
- Cited by
- 694
- References
- 38
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 10 · 2019: 7 · 2018: 9 · 2017: 11 · 2016: 9 · 2015: 13 · 2014: 20 · 2013: 16 · 2012: 25
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- vascular endothelial growth factor, TGF-beta, angiogenesis, paracrine signaling, placental growth factor, VEGF receptors, Flt-1, KDR/Flk-1, A549 cells, lung adenocarcinoma, endothelial cells, fibroblasts, epithelial cells, VEGF mRNA expression
- MeSH terms
- Animals, Cattle, Cell Line, Cells, Cultured, Endothelium, Vascular, Epithelium, Fibroblasts, Humans, Hybrid Cells, Lung Neoplasms, Lymphokines, Mice, Inbred AKR, Recombinant Proteins, Tumor Cells, Cultured, Umbilical Veins, Immunoblotting, Transforming Growth Factor beta, Endothelial Growth Factors, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review