Alitalo, Kari

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology

Angiogenesis and VEGF in CancerAxon Guidance and Neuronal Signaling

Cited by 2,894

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

Aspelund, A., Antila, S., Proulx, S. T., Karlsen, T. V., Karaman, S., Detmar, M., Wiig, H., & Alitalo, K. (2015) · Journal of Experimental Medicine

Cerebrospinal fluid and hydrocephalusLymphatic System and Diseases

Cited by 2,198

Clinical applications of angiogenic growth factors and their inhibitors

Ferrara, N., & Alitalo, K. (1999) · Nature Medicine

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 1,004

Tumor-Associated Macrophages Express Lymphatic Endothelial Growth Factors and Are Related to Peritumoral Lymphangiogenesis

Schoppmann, S. F., Birner, P., Stöckl, J., Kalt, R., Ullrich, R., Caucig, C., Kriehuber, E., Nagy, K., Alitalo, K., & Kerjaschki, D. (2002) · The American Journal of Pathology

Lymphatic System and DiseasesImmune cells in cancer

Cited by 794

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

Alitalo, K., Schwab, M., Lin, C. C., Varmus, H. E., & Bishop, J. M. (1983) · Proceedings of the National Academy of Sciences

Genomic variations and chromosomal abnormalitiesNeuroendocrine Tumor Research Advances

Cited by 761

Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells.

Pertovaara, L., Kaipainen, A., Mustonen, T., Orpana, A., Ferrara, N., Saksela, O., & Alitalo, K. (1994) · Journal of Biological Chemistry

Angiogenesis and VEGF in CancerTGF-β signaling in diseases

Cited by 694

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

Louveau, A., Plog, B. A., Antila, S., Alitalo, K., Nedergaard, M., & Kipnis, J. (2017) · Journal of Clinical Investigation

Cerebrospinal fluid and hydrocephalusLymphatic System and Diseases

Cited by 640

Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox‐1 homeobox transcription factor

Petrova, T. V., Mäkinen, T., Mäkelä, T. P., Saarela, J., Virtanen, I., Ferrell, R. E., Finegold, D. N., Kerjaschki, D., Ylä‐Herttuala, S., & Alitalo, K. (2002) · The EMBO Journal

Lymphatic System and DiseasesLymphatic Disorders and Treatments

Cited by 632

Therapeutic targeting of the angiopoietin–TIE pathway

Saharinen, P., Eklund, L., & Alitalo, K. (2017) · Nature Reviews Drug Discovery

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 620

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

Saharinen, P., Eklund, L., Miettinen, J., Wirkkala, R., Anisimov, A., Winderlich, M., Nottebaum, A., Vestweber, D., Deutsch, U., Koh, G. Y., et al. (2008) · Nature Cell Biology

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 471

FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1

Norrmén, C., Ivanov, K. I., Cheng, J., Zangger, N., Delorenzi, M., Jaquet, M., Miura, N., Puolakkainen, P., Horsley, V., Hu, J., et al. (2009) · Journal of Cell Biology

Lymphatic System and DiseasesLymphatic Disorders and Treatments

Cited by 340

Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability

Cao, R., Eriksson, A., Kubo, H., Alitalo, K., Cao, Y., & Thyberg, J. (2004) · Circulation Research

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 324

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling

Tammela, T., Zarkada, G., Nurmi, H., Jakobsson, L., Heinolainen, K., Tvorogov, D., Zheng, W., Franco, C. A., Murtomäki, A., Aranda, E., et al. (2011) · Nature Cell Biology

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 321

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

Hakanpaa, L., Sipila, T., Leppanen, V.-M., Gautam, P., Nurmi, H., Jacquemet, G., Eklund, L., Ivaska, J., Alitalo, K., & Saharinen, P. (2015) · Nature Communications

Angiogenesis and VEGF in CancerCell Adhesion Molecules Research

Cited by 287

Tie1 controls angiopoietin function in vascular remodeling and inflammation

Korhonen, E. A., Lampinen, A., Giri, H., Anisimov, A., Kim, M., Allen, B., Fang, S., D’Amico, G., Sipilä, T. J., Lohela, M., et al. (2016) · Journal of Clinical Investigation

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 283

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

Flanagan, D. J., Pentinmikko, N., Luopajärvi, K., Willis, N. J., Gilroy, K., Raven, A. P., Mcgarry, L., Englund, J. I., Webb, A. T., Scharaw, S., et al. (2021) · Nature

Wnt/β-catenin signaling in development and cancerGenetic factors in colorectal cancer

Cited by 255

A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism

Pribluda, A., Elyada, E., Wiener, Z., Hamza, H., Goldstein, R. E., Biton, M., Burstain, I., Morgenstern, Y., Brachya, G., Billauer, H., et al. (2013) · Cancer Cell

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 239

Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell–Cell Junctions and Lung Metastasis

Holopainen, T., Saharinen, P., D’Amico, G., Lampinen, A., Eklund, L., Sormunen, R., Anisimov, A., Zarkada, G., Lohela, M., Heloterä, H., et al. (2012) · JNCI: Journal of the National Cancer Institute

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 216

Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival

Lorenz, L., Axnick, J., Buschmann, T., Henning, C., Urner, S., Fang, S., Nurmi, H., Eichhorst, N., Holtmeier, R., Bódis, K., et al. (2018) · Nature

Liver physiology and pathologyAngiogenesis and VEGF in Cancer

Cited by 171

Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2

Hu, B., Guo, P., Fang, Q., Tao, H.-Q., Wang, D., Nagane, M., Su Huang, H.-J., Gunji, Y., Nishikawa, R., Alitalo, K., et al. (2003) · Proceedings of the National Academy of Sciences

Glioma Diagnosis and TreatmentProtease and Inhibitor Mechanisms

Cited by 164

Molecular anatomy of adult mouse leptomeninges

Pietilä, R., Del Gaudio, F., He, L., Vázquez-Liébanas, E., Vanlandewijck, M., Muhl, L., Mocci, G., Bjørnholm, K. D., Lindblad, C., Fletcher-Sandersjöö, A., et al. (2023) · Neuron

Barrier Structure and Function StudiesSingle-cell and spatial transcriptomics

Cited by 145

Anatomy and function of the vertebral column lymphatic network in mice

Jacob, L., Boisserand, L. S. B., Geraldo, L. H. M., de Brito Neto, J., Mathivet, T., Antila, S., Barka, B., Xu, Y., Thomas, J.-M., Pestel, J., et al. (2019) · Nature Communications

Lymphatic System and DiseasesCerebrospinal fluid and hydrocephalus

Cited by 144

Extracellular matrix proteins of human epidermal keratinocytes and feeder 3T3 cells.

Alitalo, K., Kuismanen, E., Myllylä, R., Kiistala, U., Asko-Seljavaara, S., & Vaheri, A. (1982) · The Journal of cell biology

Skin and Cellular Biology ResearchCell Adhesion Molecules Research

Cited by 140

Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions

Zheng, W., Nurmi, H., Appak, S., Sabine, A., Bovay, E., Korhonen, E. A., Orsenigo, F., Lohela, M., D’Amico, G., Holopainen, T., et al. (2014) · Genes & Development

Lymphatic System and DiseasesLymphatic Disorders and Treatments

Cited by 134