The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol.
Open accessAbstract
Methoxypolyethylene glycols of 1900 and 5000 daltons have been attached covalently to bovine serum albumin using cyanuric chloride as the coupling agent. When sufficient polymer is attached, the modified bovine serum albumin appears to lose its immunogenicity in the rabbit and, on intramuscular or intravenous injection, elicits antibodies neither to itself nor to native bovine serum albumin. It does not react with antibodies raised against native bovine serum albumin. Bovine serum albumin to which methoxypolyethylene glycol has been attached exhibits a blood circulating life in the rabbit rather similar to native bovine serum albumin, except that it is not removed from circulation by the eventual development of antibodies. Modified bovine serum albumins which had been iodinated with 125I, or prepared with [14C]cyanuric chloride, were injected intravenously in rabbits. Both labels appeared almost quantitatively in the urine after 30 days. The modified bovine serum albumins showed substantial changes in properties, such as solubility, electrophoretic mobility in acrylamide gel, ion exchange chromatography, and sedimentation, as compared with the unmodified protein.
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Cites
Maxfield, J., & Shepherd, I. W. (1975) · Polymer · doi:10.1016/0032-3861(75)90008-7 · Cited by 236
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Metadata
- Authors
- Abuchowski, A., van Es, T., Palczuk, N. C., & Davis, F. F.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1977-06
- Volume
- 252
- Issue
- 11
- Pages
- 3578-3581
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1490299254
- Cited by
- 1,358
- References
- 1
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Abuchowski, A., van Es, T., Palczuk, N. C., & Davis, F. F. (1977). Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)40291-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
