Cited by 1,361Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery

The evolution of commercial drug delivery technologies

Vargason, Ava M., Anselmo, Aaron C., Mitragotri, Samir·2021·Nature Biomedical Engineering

Abstract

Drug delivery technologies have enabled the development of many pharmaceutical products that improve patient health by enhancing the delivery of a therapeutic to its target site, minimizing off-target accumulation and facilitating patient compliance. As therapeutic modalities expanded beyond small molecules to include nucleic acids, peptides, proteins and antibodies, drug delivery technologies were adapted to address the challenges that emerged. In this Review Article, we discuss seminal approaches that led to the development of successful therapeutic products involving small molecules and macromolecules, identify three drug delivery paradigms that form the basis of contemporary drug delivery and discuss how they have aided the initial clinical successes of each class of therapeutic. We also outline how the paradigms will contribute to the delivery of live-cell therapies.

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Crossref · 10.1038/s41551-021-00698-w

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  • The ultimate goal of smart nanoparticles is that payloads better serve patients: enhance curative effect, reduce toxicity, and prolong survival.

    “The ultimate goal of the development of smart nanoparticles is that the payloads can better serve patients: enhance curative effect, reduce toxicity and prolong survival.276”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [276]

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Authors
Vargason, A. M., Anselmo, A. C., & Mitragotri, S.
Affiliations
  • University of North Carolina at Chapel Hill (US)
  • Harvard University (US)
Corresponding author
Mitragotri, Samir
Venue
Nature Biomedical Engineering
Published
2021-04-01
Volume
5
Issue
9
Pages
951-967
ISSN
2157-846X (ISSN-L)
OpenAlex
W3143156272
Cited by
1,361
References
275
Citations by year
2026: 170 · 2025: 314 · 2024: 366 · 2023: 293 · 2022: 170 · 2021: 48
FWCI
19.23
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Biomedical Engineering (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation (DGE-1650116)
  • U.S. Department of Health & Human Services | National Institutes of Health (R35GM137898, 1R01HL143806-01)
  • United States Department of Defense | Defense Threat Reduction Agency (HDTRA1-15-1-0045)
  • U.S. Department of Defense (W81XWH-19-2-0011)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords
drug delivery technology, small molecules, macromolecules, nucleic acids, proteins, immunoglobulins, medication adherence
MeSH terms
Pharmaceutical Preparations, Humans, Nucleic Acids, Peptides, Proteins, Drug Delivery Systems

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