The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Cloning and expression of a membrane receptor for secretory phospholipases A2.
Open accessAbstract
Snake venom and mammalian secretory phospholipases A2 are structurally related enzymes that have been associated with several toxic (neurotoxicity, myotoxicity, etc.), pathological (inflammation, hypersensitivity, etc.), or physiological (contraction, proliferation, etc.) processes. We have previously shown that snake venom PLA2s have specific high affinity receptors. Here, we report the molecular cloning of one of these PLA2 receptors (molecular mass approximately 180 kDa), previously purified from rabbit skeletal muscle. It is a membrane protein with a N-terminal cysteine-rich domain, a fibronectin type II domain, eight repeats of a carbohydrate recognition domain, a unique transmembrane domain, and a intracellular C-terminal domain. The 1458-residue PLA2 receptor, expressed in transfected cells, binds svPLA2 with very high affinities (Kd values approximately 10-20 pM). It also tightly binds the two structural types of msPLA2s, i.e. pancreatic PLA2 and synovial PLA2 (Kd approximately 1-10 nM). This receptor might have a key role in normal and pathological actions of secretory PLA2s.
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Cites
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Cited by
M-Type Phospholipase A 2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy
Beck, L. H., Bonegio, R. G. B., Lambeau, G., Beck, D. M., Powell, D. W., Cummins, T. D., Klein, J. B., & Salant, D. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810457 · Cited by 2,347
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Phospholipase A2 myotoxins from Bothrops snake venoms
Gutiérrez, J., & Lomonte, B. (1995) · Toxicon · doi:10.1016/0041-0101(95)00085-z · Cited by 538
Receptors for a growing family of secreted phospholipases A2
Lambeau, G. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01300-0 · Cited by 401
Self-citationBazan, N. G. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r300013-jlr200 · Cited by 247
Metadata
- Authors
- Lambeau, G., Ancian, P., Barhanin, J., & Lazdunski, M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1994-01
- Volume
- 269
- Issue
- 3
- Pages
- 1575-1578
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1499641759
- Cited by
- 279
- References
- 25
- FWCI
- 15.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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