The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Vacuolar ATPase activity is required for endosomal carrier vesicle formation.
Open accessAbstract
A proton pump, the vacuolar ATPase, is known to generate the acidic lumenal environment of endosomes and lysosomes. We have investigated the role of the vacuolar ATPase in endocytic membrane traffic by combining electron microscopy in vivo with a cell-free assay that reconstitutes endosome fusion in vitro. Our observations show that inactivation of this proton pump with bafilomycin A1 has no significant effects on internalization or recycling back to the plasma membrane. However, early endosomes become highly tubular and endocytosed markers do not appear in late endosomes. Our data strongly suggest that, upon inactivation of the proton pump, the formation of a vesicular intermediate between early and late endosomes, which we term endosomal carrier vesicle, is impaired.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS
Mellman, I., Fuchs, R., & Helenius, A. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.003311 · Cited by 2,032
Carbohydrate-Specific Receptors of the Liver
Ashwell, G., & Harford, J. (1982) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.51.070182.002531 · Cited by 1,914
Bowman, E. J., Siebers, A., & Altendorf, K. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.7972 · Cited by 1,784
Yoshimori, T., Yamamoto, A., Moriyama, Y., Futai, M., & Tashiro, Y. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47429-2 · Cited by 1,328
rab5 controls early endosome fusion in vitro
Gorvel, J.-P., Chavrier, P., Zerial, M., & Gruenberg, J. (1991) · Cell · doi:10.1016/0092-8674(91)90316-q · Cited by 1,093
Self-citationMolecular dissection of the secretory pathway
Rothman, J. E., & Orci, L. (1992) · Nature · doi:10.1038/355409a0 · Cited by 984
Serafini, T., Orci, L., Amherdt, M., Brunner, M., Kahn, R. A., & Rothmant, J. E. (1991) · Cell · doi:10.1016/0092-8674(91)90176-y · Cited by 609
Gruenberg, J., Griffiths, G., & Howell, K. E. (1989) · The Journal of cell biology · doi:10.1083/jcb.108.4.1301 · Cited by 587
Self-citationMembrane Traffic in Endocytosis: Insights from Cell-Free Assays
Gruenberg, J., & Howell, K. E. (1989) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.05.110189.002321 · Cited by 370
Self-citationIntracellular routing of transferrin and transferrin receptors in epidermoid carcinoma A431 cells
Hopkins, C. R. (1983) · Cell · doi:10.1016/0092-8674(83)90235-0 · Cited by 326
Cited by
ENDOCYTOSIS AND MOLECULAR SORTING
Mellman, I. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.575 · Cited by 1,533
Yamamoto, A., Tagawa, Y., Yoshimori, T., Moriyama, Y., Masaki, R., & Tashiro, Y. (1998) · Cell Structure and Function · doi:10.1247/csf.23.33 · Cited by 1,312
Rab7: A Key to Lysosome Biogenesis
Bucci, C., Thomsen, P., Nicoziani, P., McCarthy, J., & van Deurs, B. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.2.467 · Cited by 1,085
Mercer, J., Schelhaas, M., & Helenius, A. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060208-104626 · Cited by 1,057
Vacuolar H+-ATPase Activity Is Required for Endocytic and Secretory Trafficking in Arabidopsis
Dettmer, J., Hong-Hermesdorf, A., Stierhof, Y.-D., & Schumacher, K. (2006) · The Plant Cell · doi:10.1105/tpc.105.037978 · Cited by 852
Metadata
- Authors
- Clague, M. J., Urbé, S., Aniento, F., & Gruenberg, J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1994-01
- Volume
- 269
- Issue
- 1
- Pages
- 21-24
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1541488575
- Cited by
- 416
- References
- 25
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Vacuolar ATPase activity is required for endosomal carrier vesicle formation. https://app.cochat.ai/papers/10.1016/s0021-9258(17)42302-7
- The paper
- Clague, M. J., Urbé, S., Aniento, F., & Gruenberg, J. (1994). Vacuolar ATPase activity is required for endosomal carrier vesicle formation. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)42302-7
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
