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Primary structure of two P-type ATPases involved in copper homeostasis in Enterococcus hirae
Open accessAbstract
We cloned an operon, copAB, from Enterococcus hirae encoding two P-type ATPases of 727 and 745 amino acids, respectively. Both enzymes display heavy metal ion binding motifs in their polar N-terminal region. With an antibody against CopB, we showed on Western blots that expression of the operon is induced by either low or high ambient copper concentrations. Disruption of the copA gene renders the cells dependent, whereas copper disruption of copB results in a copper-sensitive phenotype. CopA exhibits 35% sequence similarity to CopB and 43% similarity to the ATPase encoded by the recently cloned human Mc1 gene, a gene responsible for the Menkes inborn error of copper metabolism. Our results imply that CopA and CopB are heavy metal ion ATPases that regulate the cytoplasmic copper activity, with CopA serving in the uptake and CopB in the extrusion of copper.
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Cited by
The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)
Multhaup, G., Schlicksupp, A., Hesse, L., Beher, D., Ruppert, T., Masters, C. L., & Beyreuther, K. (1996) · Science · doi:10.1126/science.271.5254.1406 · Cited by 678
Dancis, A., Yuan, D. S., Haile, D., Askwith, C., Eide, D., Moehle, C., Kaplan, J., & Klausner, R. D. (1994) · Cell · doi:10.1016/0092-8674(94)90345-x · Cited by 659
h CTR1: A human gene for copper uptake identified by complementation in yeast
Zhou, B., & Gitschier, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7481 · Cited by 567
The zntA gene of Escherichia coli encodes a Zn(II)-translocating P-type ATPase
Rensing, C., Mitra, B., & Rosen, B. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14326 · Cited by 419
Stern, B. R., Solioz, M., Krewski, D., Aggett, P., Aw, T.-C., Baker, S., Crump, K., Dourson, M., Haber, L., Hertzberg, R., et al. (2007) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400600755911 · Cited by 373
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Metadata
- Authors
- Odermatt, A., Suter, H., Krapf, R., & Solioz, M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 268
- Issue
- 17
- Pages
- 12775-12779
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2076000335
- Cited by
- 377
- References
- 0
- FWCI
- 27.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Odermatt, A., Suter, H., Krapf, R., & Solioz, M. (1993). Primary structure of two P-type ATPases involved in copper homeostasis in Enterococcus hirae. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)31455-8
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