The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)
Abstract
The transition metal ion copper(II) has a critical role in chronic neurologic diseases. The amyloid precursor protein (APP) of Alzheimer's disease or a synthetic peptide representing its copper-binding site reduced bound copper(II) to copper(I). This copper ion-mediated redox reaction led to disulfide bond formation in APP, which indicated that free sulfhydryl groups of APP were involved. Neither superoxide nor hydrogen peroxide had an effect on the kinetics of copper(II) reduction. The reduction of copper(II) to copper(I) by APP involves an electron-transfer reaction and could enhance the production of hydroxyl radicals, which could then attack nearby sites. Thus, copper-mediated toxicity may contribute to neurodegeneration in Alzheimer's disease.
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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
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Cited by
Oxidative stress hypothesis in Alzheimer’s disease
Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383
Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
Cheignon, C., Tomas, M., Bonnefont-Rousselot, D., Faller, P., Hureau, C., & Collin, F. (2018) · Redox Biology · doi:10.1016/j.redox.2017.10.014 · Cited by 2,185
Copper, iron and zinc in Alzheimer's disease senile plaques
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Gaggelli, E., Kozlowski, H., Valensin, D., & Valensin, G. (2006) · Chemical Reviews · doi:10.1021/cr040410w · Cited by 1,729
Metadata
- Authors
- Multhaup, G., Schlicksupp, A., Hesse, L., Beher, D., Ruppert, T., Masters, C. L., & Beyreuther, K.
- Venue
- Science
- Published
- 1996-03-08
- Volume
- 271
- Issue
- 5254
- Pages
- 1406-1409
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2033017137
- Cited by
- 678
- References
- 52
- FWCI
- 14.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I). https://app.cochat.ai/papers/10.1126/science.271.5254.1406
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- Multhaup, G., Schlicksupp, A., Hesse, L., Beher, D., Ruppert, T., Masters, C. L., & Beyreuther, K. (1996). The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I). Science. https://doi.org/10.1126/science.271.5254.1406
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
