The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Lysophosphatidylcholine plays an essential role in the mitogenic effect of oxidized low density lipoprotein on murine macrophages.
Open accessAbstract
We previously demonstrated that the growth of starch-induced murine macrophages was stimulated by modified low density lipoproteins, such as oxidized low density lipoprotein (Ox-LDL) and acetylated low density lipoprotein (acetyl-LDL), and that the mitogenic effect of Ox-LDL was much greater than that of acetyl-LDL (Yui, S., Sasaki, T., Miyazaki, A., Horiuchi, S., and Yamazaki, M. (1993) Arterioscler. Thromb. 13, 331-337). The present study was undertaken to elucidate the factor(s) that are involved in this growth-stimulating effect of Ox-LDL. The growth-stimulating effect of acetyl-LDL on murine resident macrophages was negligibly weak compared with that of Ox-LDL. However, the treatment of acetyl-LDL with phospholipase A2 led to an increase in lysophosphatidylcholine (lyso-PC) (75% of total phospholipids) and a concomitant increase in the mitogenic activity of acetyl-LDL. In contrast, cell-free incubation of Ox-LDL with high density lipoprotein resulted in a decrease in lyso-PC content and a concomitant loss of growth-stimulating activity. These results suggest that lyso-PC may play an essential role in the mitogenic activity of Ox-LDL.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cell proliferation in human coronary arteries.
Gordon, D., Reidy, M. A., Benditt, E. P., & Schwartz, S. M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4600 · Cited by 532
Rosenfeld, M. E., & Ross, R. (1990) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.10.5.680 · Cited by 331
Cited by
Therapeutic effects of lysophosphatidylcholine in experimental sepsis
Yan, J.-J., Jung, J.-S., Lee, J.-E., Lee, J., Huh, S.-O., Kim, H.-S., Jung, K. C., Cho, J.-Y., Nam, J.-S., Suh, H.-W., et al. (2004) · Nature Medicine · doi:10.1038/nm989 · Cited by 329
Terasaka, N., Hiroshima, A., Koieyama, T., Ubukata, N., Morikawa, Y., Nakai, D., & Inaba, T. (2003) · FEBS Letters · doi:10.1016/s0014-5793(02)03578-0 · Cited by 326
Human β-migrating very low density lipoprotein induces foam cell formation in human mesangial cells
Anami, Y., Kobori, S., Sakai, M., Kasho, M., Nishikawa, T., Yano, T., Matsuda, H., Matsumura, T., Takemura, T., & Shichiri, M. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(97)00166-4 · Cited by 16
Self-citation
Metadata
- Authors
- Sakai, M., Miyazaki, A., Hakamata, H., Sasaki, T., Yui, S., Yamazaki, M., Shichiri, M., & Horiuchi, S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1994-12
- Volume
- 269
- Issue
- 50
- Pages
- 31430-31435
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1529376098
- Cited by
- 194
- References
- 2
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Lysophosphatidylcholine plays an essential role in the mitogenic effect of oxidized low density lipoprotein on murine macrophages. https://app.cochat.ai/papers/10.1016/s0021-9258(18)31712-5
- The paper
- Sakai, M., Miyazaki, A., Hakamata, H., Sasaki, T., Yui, S., Yamazaki, M., Shichiri, M., & Horiuchi, S. (1994). Lysophosphatidylcholine plays an essential role in the mitogenic effect of oxidized low density lipoprotein on murine macrophages. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)31712-5
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
