CoChat
Sign Up
Cited by 68

The DOI matches its Crossref record.

A carboxyl-terminal fragment of lipoprotein lipase binds to the low density lipoprotein receptor-related protein and inhibits lipase-mediated uptake of lipoprotein in cells

Nykjaer, A, Nielsen, M, Lookene, A, Meyer, N, Røigaard, H, Etzerodt, M, Beisiegel, U, Olivecrona, G, Gliemann, J·1994·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(18)31759-9
Open this paper in CoChat — free account

Abstract

It has previously been shown that lipoprotein lipase can mediate uptake of remnant lipoprotein particles via binding to the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP). Binding of lipoprotein lipase, and of triglyceride-rich lipoproteins associated with the lipase, to LRP depends on an intact carboxyl-terminal folding domain of the lipase (Nykjaer, A., Bengtsson-Olivecrona, G., Lookene, A., Moestrup, S. K., Petersen, C. M., Weber, W., Beisiegel, W., and Gliemann, J. (1993) J. Biol. Chem. 268, 15048-15055). Here we show that the site for binding to the receptor is within residues 380-425 of the bovine and residues 378-423 of the human lipoprotein lipase. We demonstrate that a carboxyl-terminal fragment of human lipoprotein lipase (residues 378-448), expressed as fusion protein in Escherichia coli, binds to purified and cellular LRP but not to lipoproteins. Binding of the fragment to purified LRP was blocked by heparin. In addition, the fragment inhibited the binding of lipase and the lipase-mediated binding of lipoproteins to the purified receptor. The fragment exhibited reduced binding to proteoglycan-deficient cells. Moreover, the fragment inhibited the uptake of lipoproteins in cells mediated by the lipase via binding to heparan sulfate proteoglycans and LRP. We conclude that the fragment contains the site for binding to LRP and a candidate site for interaction with heparan sulfate proteoglycans, whereas binding to lipoproteins is i…

Overview

Integrity signals

Registry

Crossref · 10.1016/s0021-9258(18)31759-9

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 52

  1. Beisiegel, 1989, Nature, 341, 162, 10.1038/341162a0 · DOI
  2. Kowal, 1990, J. Biol. Chem., 265, 10771, 10.1016/S0021-9258(18)87014-4 · DOI · Paper page
  3. Brown, 1991, Curr. Opin. Lipidol., 2, 65, 10.1097/00041433-199104000-00002 · DOI
  4. Beisiegel, 1991, Proc. Natl. Acad. Sei. U. S. A., 88, 8342, 10.1073/pnas.88.19.8342 · DOI · Paper page
  5. Nykjaer, 1993, J. Biol. Chem., 268, 15048, 10.1016/S0021-9258(18)82436-X · DOI
  6. Chappell, 1993, J. Biol. Chem., 268, 14168, 10.1016/S0021-9258(19)85223-7 · DOI
  7. Willnow, 1994, Science, 264, 1471, 10.1126/science.7515194 · DOI
  8. Mokuno, 1994, J. Biol. Chem., 269, 13238, 10.1016/S0021-9258(17)36824-2 · DOI
  9. Luoma, 1994, J. Clin. Invest., 93, 2215, 10.1172/JCI117195 · DOI
  10. Ylä-Herttuala, 1991, Natl. Acad. Sei. U. S.A., 88, 10143, 10.1073/pnas.88.22.10143 · DOI
  11. Saxena, 1993, Biochem. Biophys. Res. Commun., 194, 769, 10.1006/bbrc.1993.1888 · DOI
  12. Saxena, 1993, J. Biol. Chem., 268, 14812, 10.1016/S0021-9258(18)82406-1 · DOI
  13. Eisenberg, 1992, J. Clin. Invest., 90, 2013, 10.1172/JCI116081 · DOI
  14. Santamarina-Fojo, 1994, Curr. Opin. Lipidol., 55, 117, 10.1097/00041433-199404000-00008 · DOI
  15. Olivecrona, 1993, Curr. Opin. Lipidol., 4, 187, 10.1097/00041433-199306000-00003 · DOI
  16. Stein, 1993, Atherosclerosis, 99, 15, 10.1016/0021-9150(93)90046-W · DOI
  17. Renier, 1993, Arterioscler. Thromb., 13, 190, 10.1161/01.ATV.13.2.190 · DOI
  18. Herz, 1990, EMBO J, 9, 1769, 10.1002/j.1460-2075.1990.tb08301.x · DOI
  19. Nykjaer, 1992, J. Biol. Chem., 267, 14543, 10.1016/S0021-9258(18)42072-8 · DOI
  20. Willnow, 1992, J. Biol. Chem., 267, 26172, 10.1016/S0021-9258(18)35732-6 · DOI
  21. Gliemann, 1994, Ann. N. Y. Acad. Sci., 737, 20, 10.1111/j.1749-6632.1994.tb44299.x · DOI
  22. Bensadoun, 1991, Annu. Rev. Nutr., 11, 217, 10.1146/annurev.nu.11.070191.001245 · DOI
  23. Lookene, 1993, Eur. J. Biochem., 213, 185, 10.1111/j.1432-1033.1993.tb17747.x · DOI
  24. Osborne, 1985, Biochemistry, 24, 5606, 10.1021/bi00341a048 · DOI
  25. Zaidan, 1985, Pediatr. Res., 19, 23, 10.1203/00006450-198501000-00007 · DOI
  26. Bengtsson, 1980, Biochem. J., 189, 625, 10.1042/bj1890625 · DOI
  27. Nakabayashi, 1982, Cancer Res., 42, 3858
  28. Liu, 1992, Biochim. Biophys. Acta, 1128, 113, 10.1016/0005-2760(92)90264-V · DOI
  29. Peterson, 1992, J. Lipid Res., 33, 1165, 10.1016/S0022-2275(20)40768-0 · DOI
  30. Moestrup, 1991, J. Biol. Chem., 266, 14011, 10.1016/S0021-9258(18)92803-6 · DOI
  31. Kovanen, 1981, Proc. Natl. Acad. Sci. U. S. A., 78, 1396, 10.1073/pnas.78.3.1396 · DOI
  32. McFarlane, 1958, Nature, 182, 53, 10.1038/182053a0 · DOI
  33. Schgger, 1987, Anal. Biochem., 166, 368, 10.1016/0003-2697(87)90587-2 · DOI
  34. Sanger, 1977, Proc. Natl. Acad. Sci. U. S. A., 74, 5463, 10.1073/pnas.74.12.5463 · DOI · Paper page
  35. Christensen, 1991, FEBS Lett, 295, 181, 10.1016/0014-5793(91)80388-J · DOI
  36. Lorentsen, 1993, J. Gen. Virol., 74, 623, 10.1099/0022-1317-74-4-623 · DOI
  37. Esko, 1988, Science, 241, 1092, 10.1126/science.3137658 · DOI
  38. Nykjaer, 1994, J. Biol. Chem., 269, 25668, 10.1016/S0021-9258(18)47301-2 · DOI
  39. Moestrup, 1993, J. Biol. Chem., 268, 13691, 10.1016/S0021-9258(19)38702-2 · DOI
  40. Datta, 1988, J. Biol. Chem., 263, 1107, 10.1016/S0021-9258(19)57271-4 · DOI
  41. Wong, 1991, Proc. Natl. Acad. Sci. U. S. A., 88, 11290, 10.1073/pnas.88.24.11290 · DOI
  42. Davis, 1992, J. Biol. Chem., 267, 21499, 10.1016/S0021-9258(19)36637-2 · DOI
  43. Bengtsson, 1979, Biochim. Biophys. Acta, 575, 471, 10.1016/0005-2760(79)90118-8 · DOI
  44. Beisiegel, 1994, Ann. N. Y. Acad. Sci., 737, 53, 10.1111/j.1749-6632.1994.tb44301.x · DOI
  45. Goldstein, 1983, Methods Enzymol., 98, 241, 10.1016/0076-6879(83)98152-1 · DOI
  46. Williams, 1994, J. Biol. Chem., 269, 8653, 10.1016/S0021-9258(17)37017-5 · DOI · Paper page
  47. van Tilbeurgh, 1994, J. Biol. Chem., 269, 4626, 10.1016/S0021-9258(17)41822-9 · DOI
  48. Obunike, 1994, J. Biol. Chem., 269, 13129, 10.1016/S0021-9258(17)36808-4 · DOI
  49. Sobel, 1992, J. Biol. Chem., 267, 8857, 10.1016/S0021-9258(19)50359-3 · DOI
  50. Ji, 1994, J. Biol. Chem., 269, 13429, 10.1016/S0021-9258(17)36850-3 · DOI
  51. Shafi, 1994, J. Lipid. Res., 35, 709, 10.1016/S0022-2275(20)41185-X · DOI
  52. Chappell, 1993, J. Biol. Chem., 268, 25487, 10.1016/S0021-9258(19)74418-4 · DOI

Cited by

Sorted by citations

Metadata

Authors
Nykjaer, A., Nielsen, M., Lookene, A., Meyer, N., Røigaard, H., Etzerodt, M., Beisiegel, U., Olivecrona, G., & Gliemann, J.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1994-12
Volume
269
Issue
50
Pages
31747-31755
ISSN
0021-9258
DOI
10.1016/s0021-9258(18)31759-9
Cited by
68
References
0
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review