CoChat
Sign Up
Cited by 103

The DOI matches its Crossref record.

The carboxyl-terminal domain of lipoprotein lipase binds to the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) and mediates binding of normal very low density lipoproteins to LRP

Williams, S.E., Inoue, I., Tran, H., Fry, G.L., Pladet, M.W., Iverius, P.H., Lalouel, J.M., Chappell, D.A., Strickland, D.K.·1994·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(17)37017-5
Open this paper in CoChat — free account

Abstract

Lipoprotein lipase (LPL) binds with high affinity to the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) and promotes binding, uptake, and degradation of normal triglyceride-rich lipoproteins in a process mediated by LRP (Chappell, D. A., Fry, G. L., Naknitx, M.A., Muhonen, L. E., Pladet, M. W., Iverius, P-H., and Strickland, D. K. (1993) J. Biol. Chem. 268, 14168-14175). To localize the portion of LPL that is responsible for interacting with LRP, fragments of LPL were expressed in bacteria. A fragment of human LPL containing the COOH-terminal domain (residues 313-448, designated LPLC) which lacks the catalytic site was able to bind to LRP. Purified LRP bound specifically to microtiter wells coated with LPL or LPLC with KD values of 2.8 and 5 nM, respectively. The effects of several mutations of LPLC were tested. Mutation of Lys407 to Ala reduced the affinity of LPLC for LRP by approximately 10-fold. Like native LPL, LPLC prevented the binding of activated alpha 2-macroglobulin and the 39-kDa receptor-associated protein to LRP and inhibited the internalization and degradation of activated alpha 2-macroglobulin and receptor-associated protein in cultured fibroblasts. LPLC also bound to 125I-labeled human normal triglyceride-rich lipoproteins and promoted their binding to purified LRP and to cultured cells. Mutation of Trp393 and Trp394 to Ala completely abolished the ability of LPLC to bind to lipoproteins, but had little effect on its int…

Overview

Integrity signals

Registry

Crossref · 10.1016/s0021-9258(17)37017-5

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 37

  1. Nilsson-Ehle, 1980, Annu. Rev. Biochem., 49, 667, 10.1146/annurev.bi.49.070180.003315 · DOI
  2. Auwerx, 1992, Crit. Rev. Clin. Lab. Sci., 29, 243, 10.3109/10408369209114602 · DOI
  3. Iverius, 1976, J. Biol. Chem., 251, 7791, 10.1016/S0021-9258(19)57004-1 · DOI
  4. Osborne, 1985, Biochemistry, 24, 5606, 10.1021/bi00341a048 · DOI
  5. Winkler, 1990, Nature, 343, 771, 10.1038/343771a0 · DOI
  6. Derewenda, 1991, J. Biol. Chem., 266, 23112, 10.1016/S0021-9258(18)54470-7 · DOI
  7. Beisiegel, 1991, Proc. Natl. Acad. Sci. U. S. A., 88, 8342, 10.1073/pnas.88.19.8342 · DOI · Paper page
  8. Chappell, 1993, J. Biol. Chem., 268, 14168, 10.1016/S0021-9258(19)85223-7 · DOI
  9. Herz, 1988, EMBO J., 7, 1127, 10.1002/j.1460-2075.1988.tb03306.x · DOI
  10. Strickland, 1990, J. Biol. Chem., 265, 17401, 10.1016/S0021-9258(18)38172-9 · DOI · Paper page
  11. Kristensen, 1990, FEBS Lett., 276, 151, 10.1016/0014-5793(90)80530-V · DOI
  12. Ashcom, 1990, J. Cell Biol., 110, 1041, 10.1083/jcb.110.4.1041 · DOI
  13. Moestrup, 1989, J. Biol. Chem., 264, 15574, 10.1016/S0021-9258(19)84870-6 · DOI
  14. Beisiegel, 1989, Nature, 341, 162, 10.1038/341162a0 · DOI
  15. Kowal, 1989, Proc. Natl. Acad. Sci. U. S. A., 86, 5810, 10.1073/pnas.86.15.5810 · DOI
  16. Kounnas, 1992, J. Biol. Chem., 267, 12420, 10.1016/S0021-9258(18)42291-0 · DOI
  17. Bu, 1992, Proc. Natl. Acad. Sci. U. S. A., 89, 7427, 10.1073/pnas.89.16.7427 · DOI
  18. Kounnas, 1993, J. Biol. Chem., 268, 21862, 10.1016/S0021-9258(20)80620-6 · DOI
  19. Herz, 1992, Cell, 71, 411, 10.1016/0092-8674(92)90511-A · DOI · Paper page
  20. Orth, 1992, Proc. Natl. Acad. Sci. U. S. A., 89, 7422, 10.1073/pnas.89.16.7422 · DOI
  21. Nykjaer, 1992, J. Biol. Chem., 267, 14543, 10.1016/S0021-9258(18)42072-8 · DOI
  22. Willnow, 1992, J. Biol. Chem., 267, 26172, 10.1016/S0021-9258(18)35732-6 · DOI
  23. Chappell, 1992, J. Biol. Chem., 267, 25764, 10.1016/S0021-9258(18)35675-8 · DOI · Paper page
  24. Williams, 1992, J. Biol. Chem., 267, 9035, 10.1016/S0021-9258(19)50384-2 · DOI · Paper page
  25. Hall, 1978, Biochem. J., 173, 27, 10.1042/bj1730027 · DOI
  26. Jones, 1972, Biochem. J., 127, 187, 10.1042/bj1270187 · DOI
  27. Strickland, 1991, J. Biol. Chem., 266, 13364, 10.1016/S0021-9258(18)98848-4 · DOI
  28. Bradford, 1976, Anal. Biochem., 72, 248, 10.1016/0003-2697(76)90527-3 · DOI · Paper page
  29. Liu, 1992, Biochim. Biophys. Acta, 1128, 113, 10.1016/0005-2760(92)90264-V · DOI
  30. Munson, 1980, Anal. Biochem., 107, 220, 10.1016/0003-2697(80)90515-1 · DOI
  31. Attri, 1983, Anal. Biochem., 133, 142, 10.1016/0003-2697(83)90235-X · DOI
  32. Weisgraber, 1983, J. Biol. Chem., 258, 12348, 10.1016/S0021-9258(17)44181-0 · DOI · Paper page
  33. Nykjaer, 1993, J. Biol. Chem., 268, 15048, 10.1016/S0021-9258(18)82436-X · DOI
  34. Felts, 1975, Biochem. Biophys. Res. Commun., 66, 1467, 10.1016/0006-291X(75)90524-0 · DOI · Paper page
  35. Wong, 1991, Proc. Natl. Acad. Sci. U. S. A., 88, 11290, 10.1073/pnas.88.24.11290 · DOI
  36. Lookene, 1993, Eur. J. Biochem., 213, 185, 10.1111/j.1432-1033.1993.tb17747.x · DOI
  37. Hata, 1993, J. Biol. Chem., 268, 8447, 10.1016/S0021-9258(18)52896-9 · DOI

Cited by

Sorted by citations

See all 103

Metadata

Authors
Williams, S. E., Inoue, I., Tran, H., Fry, G. L., Pladet, M. W., Iverius, P. H., Lalouel, J. M., Chappell, D. A., & Strickland, D. K.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1994-03
Volume
269
Issue
12
Pages
8653-8658
ISSN
0021-9258
DOI
10.1016/s0021-9258(17)37017-5
Cited by
103
References
0
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review