The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.
Open accessAbstract
Exposure of NG108-15 hybrid cells to islet-activating protein (IAP), pertussis toxin, caused strong ADP-ribosylation of one of the membrane proteins with a molecular weight of 41,000. This ADP-ribosylation was paralleled by decreases in the inhibition of cAMP accumulation in intact cells or associated with reversal of the inhibition of GTP-dependent membrane adenylate cyclase, via alpha-adrenergic, cholinergic muscarinic, or opiate receptors. The affinity of these receptors for agonists was lowered by guanyl-5'-yl beta-gamma-imidodiphosphate (Gpp(NH)p) reflecting their coupling to the guanine nucleotide regulatory protein in this cell line. This effect of Gpp(NH)p was lost in membranes of IAP-treated cells; in the absence of Gpp(NH)p, the affinity for agonist was lower in treated than in nontreated cells. In contrast, the function of these receptors to bind antagonists remained unaltered in IAP-treated cells. Thus, IAP treatment of NG108-15 cells caused specific uncoupling of negative signal transduction from inhibitory receptors to the adenylate cyclase catalytic unit via the guanine nucleotide regulatory protein, as a result of ADP-ribosylation of one of the subunits of the regulatory protein.
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 317,331
The role of hormone receptors and GTP-regulatory proteins in membrane transduction
Rodbell, M. (1980) · Nature · doi:10.1038/284017a0 · Cited by 1,749
Biochemical Properties of Hormone-Sensitive Adenylate Cyclase
Ross, E. M., & Gilman, A. G. (1980) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.49.070180.002533 · Cited by 1,013
Katada, T., & Ui, M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.10.3129 · Cited by 811
Self-citationHonma, M., Satoh, T., Takezawa, J., & Ui, M. (1977) · Biochemical Medicine · doi:10.1016/0006-2944(77)90060-6 · Cited by 664
Self-citationKatada, T., & Ui, M. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34558-7 · Cited by 600
Self-citationMorphine receptors as regulators of adenylate cyclase activity.
Sharma, S. K., Nirenberg, M., & Klee, W. A. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.2.590 · Cited by 531
Relationship between the beta-adrenergic receptor and adenylate cyclase.
Ross, E. M., Maguire, M. E., Sturgill, T. W., Biltonen, R. L., & Gilman, A. G. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40089-5 · Cited by 488
Hazeki, O., & Ui, M. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69693-6 · Cited by 330
Self-citationAn Agonist-Specific Effect of Guanine Nucleotides on Binding to the Beta Adrenergic Receptor
MAGUIRE, M. E., VAN ARSDALE, P. M., & GILMAN, A. G. (1976) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10769-4 · Cited by 323
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Neve, K. A., Seamans, J. K., & Trantham‐Davidson, H. (2004) · Journal of Receptors and Signal Transduction · doi:10.1081/lrst-200029981 · Cited by 837
Bacterial toxins: cellular mechanisms of action
Middlebrook, J. L., & Dorland, R. B. (1984) · Microbiological Reviews · doi:10.1128/mmbr.48.3.199-221.1984 · Cited by 357
Third Generation Antipsychotic Drugs: Partial Agonism or Receptor Functional Selectivity?
Mailman, R., & Murthy, V. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790361461 · Cited by 311
Okajima, F., Katada, T., & Ui, M. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88845-7 · Cited by 278
Self-citationDifferential binding properties of oripavines at cloned μ- and δ-opioid receptors
Lee, K. O., Akil, H., Woods, J. H., & Traynor, J. R. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00460-4 · Cited by 117
Metadata
- Authors
- Kurose, H., Katada, T., Amano, T., & Ui, M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1983-04
- Volume
- 258
- Issue
- 8
- Pages
- 4870-4875
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1653242653
- Cited by
- 494
- References
- 29
- FWCI
- 22.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kurose, H., Katada, T., Amano, T., & Ui, M. (1983). Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)32507-9
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