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Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts.
Open accessAbstract
The lymphokine interleukin 1 (IL-1) rapidly increases the levels of mRNA encoding nerve growth factor (NGF) in primary cultures of fibroblasts isolated from adult rat sciatic nerves. The effect of IL-1 on NGF-mRNA was not inhibited by cycloheximide, which itself increased the NGF-mRNA. From the blocking ability of actinomycin D, it was deduced that the IL-1 action depends on continuous RNA synthesis and that the half-life of NGF-mRNA is about 90 min. Nuclear run-on studies showed that, although IL-1 enhances the low basic NGF-mRNA transcription, the main effect of IL-1 results from stabilization of the NGF-mRNA. In addition, indirect evidence is presented indicating that the IL-1 effect of NGF-mRNA levels involves activation of phospholipase A2.
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Citations
Cited by
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Ross, J. (1995) · Microbiological Reviews · doi:10.1128/mr.59.3.423-450.1995 · Cited by 1,411
Zafra, F., Hengerer, B., Leibrock, J., Thoenen, H., & Lindholm, D. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07564.x · Cited by 897
Self-citationIsackson, P. J., Huntsman, M. M., Murray, K. D., & Gall, C. M. (1991) · Neuron · doi:10.1016/0896-6273(91)90234-q · Cited by 711
Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor
Stöckli, K. A., Lottspeich, F., Sendtner, M., Masiakowski, P., Carroll, P., Götz, R., Lindholm, D., & Thoenen, H. (1989) · Nature · doi:10.1038/342920a0 · Cited by 616
Self-citationLight regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex.
Castrén, E., Zafra, F., Thoenen, H., & Lindholm, D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.20.9444 · Cited by 513
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Metadata
- Authors
- Lindholm, D., Heumann, R., Hengerer, B., & Thoenen, H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1988-11
- Volume
- 263
- Issue
- 31
- Pages
- 16348-16351
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1480365149
- Cited by
- 242
- References
- 0
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lindholm, D., Heumann, R., Hengerer, B., & Thoenen, H. (1988). Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)37599-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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