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Cited by 1,411

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

mRNA stability in mammalian cells

Ross, J·1995·Microbiological Reviews
DOI 10.1128/mr.59.3.423-450.1995
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Abstract

This review concerns how cytoplasmic mRNA half-lives are regulated and how mRNA decay rates influence gene expression. mRNA stability influences gene expression in virtually all organisms, from bacteria to mammals, and the abundance of a particular mRNA can fluctuate manyfold following a change in the mRNA half-life, without any change in transcription. The processes that regulate mRNA half-lives can, in turn, affect how cells grow, differentiate, and respond to their environment. Three major questions are addressed. Which sequences in mRNAs determine their half-lives? Which enzymes degrade mRNAs? Which (trans-acting) factors regulate mRNA stability, and how do they function? The following specific topics are discussed: techniques for measuring eukaryotic mRNA stability and for calculating decay constants, mRNA decay pathways, mRNases, proteins that bind to sequences shared among many mRNAs [like poly(A)- and AU-rich-binding proteins] and proteins that bind to specific mRNAs (like the c-myc coding-region determinant-binding protein), how environmental factors like hormones and growth factors affect mRNA stability, and how translation and mRNA stability are linked. Some perspectives and predictions for future research directions are summarized at the end.

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Crossref · 10.1128/mr.59.3.423-450.1995

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  • Microinjection of CRISPR/Cas9 RNA components into cells results in a finite duration of action owing to the natural decay of mRNA within eukaryotic cells.

    “With some exceptions, microinjection of CRISPR/Cas9 RNA components into cells results in a finite duration of action of the system, owing to the natural decay of mRNA within eukaryotic cells (Ross, 1995).”

    From Delivering CRISPR: a review of the challenges and approaches (2018) · cites this paper as Ross, 1995

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Metadata

Authors
Ross, J.
Affiliations
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706, USA.
Venue
Microbiological Reviews
Publisher
American Society for Microbiology
Published
1995-09
Volume
59
Issue
3
Pages
423-450
ISSN
0146-0749
DOI
10.1128/mr.59.3.423-450.1995
Cited by
1,411
References
3
Language
en
Licence
journals.asm.org/non-commercial-tdm-license (tdm)

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