The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Transforming growth factor beta regulates the metabolism of proteoglycans in bovine cartilage organ cultures.
Open accessAbstract
The effect of transforming growth factor beta (TGF-beta) has been studied in a bovine articular cartilage organ culture. The peptide stimulates synthesis of proteoglycans in a dose-dependent manner, reaching saturation at 10 ng/ml. This dose gave an approximate 7-fold increase in synthesis over basal controls. In addition, the peptide decreased the rates of catabolism of proteoglycans with an approximately 2-fold maximal effect seen at 5 ng/ml. At the latter concentration, TGF-beta prevented the 4-fold loss of proteoglycans which occurred in cultures maintained under basal conditions over the course of 3 weeks. There was no increase in cell (DNA) content of the cartilage explants under these conditions of TGF-beta treatment, and the net collagen content of the explants remained constant.
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Cites
A simple, rapid, and sensitive DNA assay procedure
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A Direct Spectrophotometric Microassay for Sulfated Glycosaminoglycans in Cartilage Cultures
Farndale, R. W., Sayers, C. A., & Barrett, A. J. (1982) · Connective Tissue Research · doi:10.3109/03008208209160269 · Cited by 1,347
Edwards, D. R., Murphy, G., Reynolds, J. J., Whitham, S. E., Docherty, A. J., Angel, P., & Heath, J. K. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02449.x · Cited by 1,221
Role of transforming growth factor-beta in the development of the mouse embryo.
Heine, U., Munoz, E. F., Flanders, K. C., Ellingsworth, L. R., Lam, H. Y., Thompson, N. L., Roberts, A. B., & Sporn, M. B. (1987) · The Journal of cell biology · doi:10.1083/jcb.105.6.2861 · Cited by 745
Self-citationRossi, P., Karsenty, G., Roberts, A. B., Roche, N. S., Sporn, M. B., & de Crombrugghe, B. (1988) · Cell · doi:10.1016/s0092-8674(88)80033-3 · Cited by 612
Self-citationOsteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro.
Robey, P. G., Young, M. F., Flanders, K. C., Roche, N. S., Kondaiah, P., Reddi, A. H., Termine, J. D., Sporn, M. B., & Roberts, A. B. (1987) · The Journal of cell biology · doi:10.1083/jcb.105.1.457 · Cited by 557
Self-citationCartilage-inducing factor-A. Apparent identity to transforming growth factor-beta.
Seyedin, S. M., Thompson, A. Y., Bentz, H., Rosen, D. M., McPherson, J. M., Conti, A., Siegel, N. R., Galluppi, G. R., & Piez, K. A. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38436-3 · Cited by 521
Articular Cartilage Biochemistry
(1987) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(87)90023-2 · Cited by 496
Cited by
Transforming Growth Factor‐β: Major Role in Regulation of Extracellular Matrix
ROBERTS, A. B., HEINE, U. I., FLANDERS, K. C., & SPORN, M. B. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb17931.x · Cited by 696
Self-citationOkuda, S., Languino, L. R., Ruoslahti, E., & Border, W. A. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114731 · Cited by 546
Synergistic Action of Growth Factors and Dynamic Loading for Articular Cartilage Tissue Engineering
Mauck, R. L., Nicoll, S. B., Seyhan, S. L., Ateshian, G. A., & Hung, C. T. (2003) · Tissue Engineering · doi:10.1089/107632703768247304 · Cited by 337
Metadata
- Authors
- Morales, T. I., & Roberts, A. B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1988-09
- Volume
- 263
- Issue
- 26
- Pages
- 12828-12831
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1582355914
- Cited by
- 274
- References
- 17
- FWCI
- 13.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Morales, T. I., & Roberts, A. B. (1988). Transforming growth factor beta regulates the metabolism of proteoglycans in bovine cartilage organ cultures. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)37634-8
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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