The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro.
Open accessAbstract
Transforming growth factor-type beta (TGF-beta) has been identified as a constituent of bone matrix (Seyedin, S. M., A. Y. Thompson, H. Bentz, D. M. Rosen, J. M. McPherson, A. Conti, N. R. Siegel, G. R. Gallupi, and K. A. Piez, 1986, J. Biol. Chem. 261:5693-5695). We used both developing bone and bone-forming cells in vitro to demonstrate the cellular origin of this peptide. TGF-beta mRNA was detected by Northern analysis in both developing bone tissue and fetal bovine bone-forming cells using human cDNA probes. TGF-beta was shown to be synthesized and secreted by metabolically labeled bone cell cultures by immunoprecipitation from the medium. Further, TGF-beta activity was demonstrated in conditioned media from these cultures by competitive radioreceptor and growth promotion assays. Fetal bovine bone cells (FBBC) were found to have relatively few TGF-beta receptors (5,800/cell) with an extremely low Kd of 2.2 pM (high binding affinity). In contrast to its inhibitory effects on the growth of many cell types including osteosarcoma cell lines, TGF-beta stimulated the growth of subconfluent cultures of FBBC; it had little effect on the production of collagen by these cells. We conclude that bone-forming cells are a source for the TGF-beta that is found in bone, and that these cells may be modulated by this factor in an autocrine fashion.
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Cites
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Cited by
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Franz‐Odendaal, T. A., Hall, B. K., & Witten, P. E. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20603 · Cited by 795
Transforming Growth Factor-β1 to the Bone
Janssens, K., ten Dijke, P., Janssens, S., & Van Hul, W. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0001 · Cited by 710
Vukicevic, S., Kleinman, H. K., Luyten, F. P., Roberts, A. B., Roche, N. S., & Reddi, A. H. (1992) · Experimental Cell Research · doi:10.1016/0014-4827(92)90397-q · Cited by 696
Self-citationTransforming Growth Factor‐β: Major Role in Regulation of Extracellular Matrix
ROBERTS, A. B., HEINE, U. I., FLANDERS, K. C., & SPORN, M. B. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb17931.x · Cited by 696
Self-citationPlatelet-Rich Plasma and Platelet Gel: A Review
Everts, P. A. M., Knape, J. T. A., Weibrich, G., Schönberger, J. P. A. M., Hoffmann, J., Overdevest, E. P., Box, H. A. M., & van Zundert, A. (2006) · The Journal of ExtraCorporeal Technology · doi:10.1051/ject/200638174 · Cited by 580
Metadata
- Authors
- Robey, P. G., Young, M. F., Flanders, K. C., Roche, N. S., Kondaiah, P., Reddi, A. H., Termine, J. D., Sporn, M. B., & Roberts, A. B.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1987-07-01
- Volume
- 105
- Issue
- 1
- Pages
- 457-463
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2119491066
- Cited by
- 557
- References
- 1
- FWCI
- 14.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro. https://app.cochat.ai/papers/10.1083/jcb.105.1.457
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- Robey, P. G., Young, M. F., Flanders, K. C., Roche, N. S., Kondaiah, P., Reddi, A. H., Termine, J. D., Sporn, M. B., & Roberts, A. B. (1987). Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro. The Journal of cell biology. https://doi.org/10.1083/jcb.105.1.457
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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