The DOI matches its Crossref record.
Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage.
Open accessAbstract
An Mr = 524,000 oligomeric protein was isolated from bovine cartilage and designated COMP (Cartilage Oligomeric Matrix Protein). The protein is composed of disulfide-bonded subunits with an apparent Mr of 100,000 each. It is markedly anionic, probably due to its high contents of aspartic acid and glutamic acid, as well as to its substitution with negatively charged carbohydrates. COMP was found in all cartilages analyzed, but could not be detected in other tissues by enzyme-linked immunosorbent assay of guanidine HCl extracts. Within a given cartilage, COMP shows a preferential localization to the territorial matrix surrounding the chondrocytes.
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Citations
Cited by
Thrombospondins: structure and regulation of expression
Bornstein, P. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.14.1426766 · Cited by 349
Cartilage Oligomeric Matrix Protein (COMP): A Biomarker of Arthritis
Tseng, S., Reddi, A. H., & Di Cesare, P. E. (2009) · Biomarker Insights · doi:10.4137/bmi.s645 · Cited by 204
Vilı́m, V., Vytášek, R., Olejárová, M., Macháček, S., Gatterová, J., Procházka, B., Kraus, V. B., & Pavelka, K. (2001) · Osteoarthritis and Cartilage · doi:10.1053/joca.2001.0434 · Cited by 92
Lorenzo, P., Aspberg, A., Saxne, T., & Önnerfjord, P. (2017) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2017.04.004 · Cited by 28
Sandstedt, J., Vargmar, K., Björkman, K., Ruetschi, U., Bergström, G., Hultén, L. M., & Skiöldebrand, E. (2021) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.120.314720 · Cited by 15
Metadata
- Authors
- Hedbom, E., Antonsson, P., Hjerpe, A., Aeschlimann, D., Paulsson, M., Rosa-Pimentel, E., Sommarin, Y., Wendel, M., Oldberg, A., & Heinegård, D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1992-03
- Volume
- 267
- Issue
- 9
- Pages
- 6132-6136
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1550768646
- Cited by
- 525
- References
- 0
- FWCI
- 10.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage. https://app.cochat.ai/papers/10.1016/s0021-9258(18)42671-3
- The paper
- Hedbom, E., Antonsson, P., Hjerpe, A., Aeschlimann, D., Paulsson, M., Rosa-Pimentel, E., Sommarin, Y., Wendel, M., Oldberg, A., & Heinegård, D. (1992). Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)42671-3
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
