The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
A differential location of phosphoinositide kinases, diacylglycerol kinase, and phospholipase C in the nuclear matrix.
Open accessAbstract
Several enzymes involved in the phosphoinositide metabolism have been shown to be present in nuclei of rat liver and Friend cells. In this paper we demonstrate that nuclear matrices of mouse NIH 3T3-fibroblasts and rat liver cells, isolated by nuclease treatment and high salt extraction, contain phosphatidylinositol 4-kinase (PdtIns 4-kinase), phosphatidylinositol 4-phosphate 5-kinase (PtdIns(4)P 5-kinase), diacylglycerol kinase, and phospholipase C. By a selective extraction the nucleus can be dissected in the peripheral matrix (lamina-pore complex) and the internal matrix as shown by using marker antibodies. Surprisingly, PtdIns 4-kinase was found exclusively in the peripheral nuclear matrix, whereas PtdIns(4)P 5-kinase was found to be associated to internal matrix structures. Diacylglycerol kinase and phospholipase C activities were also preferentially detected in the internal matrix. These data demonstrate a differential localization of the phosphoinositide kinases in the nucleus and suggest that the phosphoinositide metabolism may play a specific role in the nucleus.
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Cites
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INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS
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Intermediate Filaments: A Chemically Heterogeneous, Developmentally Regulated Class of Proteins
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The nuclear lamina is a meshwork of intermediate-type filaments
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Different intermediate-sized filaments distinguished by immunofluorescence microscopy.
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Cited by
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Multiple roles of phosphoinositide-specific phospholipase C isozymes
Suh, P.-G., Park, J.-I., Manzoli, L., Cocco, L., Peak, J. C., Katan, M., Fukami, K., Kataoka, T., Yun, S.-U., & Ryu, S.-H. (2008) · BMB Reports · doi:10.5483/bmbrep.2008.41.6.415 · Cited by 501
Irvine, R. F. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1100 · Cited by 406
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Metadata
- Authors
- Payrastre, B., Nievers, M., Boonstra, J., Breton, M., Verkleij, A. J., & Van Bergen en Henegouwen, P. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1992-03
- Volume
- 267
- Issue
- 8
- Pages
- 5078-5084
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1515371688
- Cited by
- 277
- References
- 36
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Payrastre, B., Nievers, M., Boonstra, J., Breton, M., Verkleij, A. J., & Van Bergen en Henegouwen, P. M. (1992). A differential location of phosphoinositide kinases, diacylglycerol kinase, and phospholipase C in the nuclear matrix. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)42732-9
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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