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Cited by 727

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta.

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Ignotz, R A, Endo, T, Massagué, J·1987·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(18)48258-0
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Abstract

Human platelet-derived transforming growth factor-beta (TGF-beta 1) increases the accumulation of the extracellular matrix proteins, fibronectin and type I collagen, in mesenchymal and epithelial cells. To determine the basis for this effect, we have examined the levels of mRNAs corresponding to fibronectin and alpha 2(I) procollagen in NRK-49 rat fibroblasts and L6E9 rat myoblasts treated with TGF-beta 1. TGF-beta 1 increased severalfold the levels of mRNAs for both proteins. The kinetics of this effect were similar for both mRNA species. The increase in fibronectin and alpha 2(I) procollagen mRNAs was detectable 2 h after addition of TGF-beta 1 to the cells and their maximal levels remained constant for several days. Actinomycin D, but not cycloheximide, inhibited the increase in fibronectin and alpha 2(I) procollagen mRNA levels induced by TGF-beta 1. The results indicate that TGF-beta 1 controls the composition and abundance of extracellular matrices at least in part by inducing a coordinate increase in the levels of fibronectin and type I collagen mRNAs.

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Cites

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Research works printed but not linked: 34

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Metadata

Authors
Ignotz, R. A., Endo, T., & Massagué, J.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1987-05
Volume
262
Issue
14
Pages
6443-6446
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(18)48258-0
OpenAlex
W1595561754
Cited by
727
References
1
FWCI
21.40
Type
journal article
Language
en
Open access
hybrid
Licence

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CoChat. (2026). Citation check: Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta. https://app.cochat.ai/papers/10.1016/s0021-9258(18)48258-0
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Ignotz, R. A., Endo, T., & Massagué, J. (1987). Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)48258-0

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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