The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Type beta transforming growth factor is an inhibitor of myogenic differentiation.
Open accessAbstract
We have investigated the effect of type beta transforming growth factor (TGF-beta) on the differentiation of skeletal muscle myoblasts. TGF-beta potently (ID50 approximately 10 pM) prevents established cell lines and primary cultures of rat and chicken embryo myoblasts from fusing into multinucleated myotubes. Inhibition of morphological differentiation by TGF-beta correlates with inhibition of the expression of muscle-specific mRNAs and proteins, strong induction of extracellular matrix type I collagen and fibronectin, and a marked tendency of the treated myoblasts to aggregate into densely multilayered arrays or clusters. Myogenic differentiation can resume after removal of TGF-beta from the medium. Examination of the time of action of TGF-beta shows that myoblasts stochastically reach a point beyond which they become insensitive to the inhibitory action of TGF-beta. This resistance of committed myoblasts to the inhibitory action of TGF-beta is not associated with any measurable change in the number or affinity of TGF-beta receptors in those cells. The results indicate that TGF-beta is a potent inhibitor of myogenesis and may regulate muscle development in vivo.
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Citations
Cites
Burton, K. (1956) · Biochemical Journal · doi:10.1042/bj0620315 · Cited by 14,090
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Self-citation
Cited by
TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology
Morikawa, M., Derynck, R., & Miyazono, K. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021873 · Cited by 1,321
Transforming Growth Factor‐β: Major Role in Regulation of Extracellular Matrix
ROBERTS, A. B., HEINE, U. I., FLANDERS, K. C., & SPORN, M. B. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb17931.x · Cited by 696
GDF11 increases with age and inhibits skeletal muscle regeneration
Egerman, M. A., Cadena, S. M., Gilbert, J. A., Meyer, A., Nelson, H. N., Swalley, S. E., Mallozzi, C., Jacobi, C., Jennings, L. L., Clay, I., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.010 · Cited by 527
Cell adhesion protein receptors as targets for transforming growth factor-$beta; action
IGNOTZ, R. (1987) · Cell · doi:10.1016/0092-8674(87)90146-2 · Cited by 485
Clegg, C. H., Linkhart, T. A., Olwin, B. B., & Hauschka, S. D. (1987) · The Journal of cell biology · doi:10.1083/jcb.105.2.949 · Cited by 478
Metadata
- Authors
- Massagué, J., Cheifetz, S., Endo, T., & Nadal-Ginard, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-11
- Volume
- 83
- Issue
- 21
- Pages
- 8206-8210
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1987726188
- Cited by
- 557
- References
- 2
- FWCI
- 16.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Massagué, J., Cheifetz, S., Endo, T., & Nadal-Ginard, B. (1986). Type beta transforming growth factor is an inhibitor of myogenic differentiation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.21.8206
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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