Cited by 198Iron Metabolism and DisordersTrace Elements in HealthPlant Micronutrient Interactions and Effects

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Regulation of the transferrin-independent iron transport system in cultured cells.

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Kaplan, J, Jordan, I, Sturrock, A·1991·Journal of Biological Chemistry

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Abstract

Mammalian cells accumulate iron via the binding of transferrin to high affinity surface receptors, or through a transferrin-independent pathway which involves the uptake of iron-organic anion chelates by a membrane-based transport system. Previously we determined that the transferrin-independent transport system was present on a wide variety of cultured cells (Sturrock, A., Alexander, J., Lamb, J., Craven, C. M., and Kaplan, J. (1990) J. Biol. Chem. 265, 3139-3145). In this communication we demonstrate that the transferrin-independent iron uptake system is regulated differently than the transferrin-mediated pathway. The activity of the transferrin-independent system was unaffected by changes in cellular growth rate, induction of DNA synthesis and cell division, or depletion of cellular iron. Exposure of cells to ferric or ferrous iron, however, resulted in a time-dependent increase in transport activity, due to a change in Vmax with no change in Km. Increased transport activity was seen in a variety of cultured cell types, occurred in the presence of cycloheximide, and persisted for hours after removal of iron. The ability of other transition metals to induce changes in transport, or to compete with iron for accumulation by the transferrin-independent uptake system, was critically dependent on the composition of the media in which the cells were incubated. Metals such as Cu2+ or Zn2+, but not Cd2+ or Mn2+, when dissolved in a balanced salt solution buffered with 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, induced changes in the transferrin-independent iron transport system. The same metals which induced changes in transport were ineffective in media containing amino acids, ascorbate, or N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine. The Vmax of the transferrin-independent iron transport system was also elevated by increases in intracellular Ca2+. The effect of iron on transport activity, however, did not result from an iron-induced release of intracellular Ca2+. These results suggest a novel form of regulation in which the presence of extracellular iron induces the appearance of previously cryptic transporters and thus accelerates the clearance of potentially toxic molecules.

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Background
Cerebellar granule cells acquire transferrin-free iron by a carrier-mediated process
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Background
A New Effect of Aluminum on Iron Metabolism in Mammalian Cells
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RETRACTED ARTICLE: Identification of a novel Na+-coupled Fe3+-citrate transport system, distinct from mammalian INDY, for uptake of citrate in mammalian cells
Ogura, J., Babu, E., Miyauchi, S., Ramachandran, S., Nemeth, E., Bhutia, Y. D., & Ganapathy, V. (2018) · Scientific Reports · doi:10.1038/s41598-018-20620-w · Cited by 2
Retracted
Reharnessing the therapeutic potential of gallium-based compounds in oncology: From the laboratory to the clinic
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“However, when plasma iron concentration exceeds the iron binding capacity of transferrin [4 –7 ], which occurs in iron-overload disorders such as haemochromatosis [ 8 , 9 ], thalassaemia and atransferrinanaemia [ 10 , 11 ], NTBI will be detectable in plasma.”
Potential Role of Chloroquine in Macrophageal Iron Mobilization
Nweneka, C. V. (2016) · Pharmaceutica Analytica Acta · doi:10.4172/2153-2435.1000505
“Macrophages acquire iron from various iron-containing proteins in the body such as transferrin, lactoferrin, haptoglobin-Hb complexes, senescent red blood cells and possibly direct uptake of ferric and ferrous iron [28,29].”
Background
Regulation of iron metabolism in higher eukaryotes: iron–sulfur centers as genetic switches
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A comparative study of the antiproliferative activity of iron chelators PIH, SIH and their light-activated caged derivatives in skin cells
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Iron Deprivation Treatment of Breast Cancer: Preclinical Studies
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Rashed, A. A. (2012) · Surrey Research Insight Open Access (The University of Surrey)
Relationships between iron, oxidative stress, glycated proteins and the development of atherosclerosis in Type 2 diabetes
Aljwaid, H. (2015) · PEARL (University of Plymouth) · doi:10.24382/2587
Potential for Extracellular Hydroxyl Radical Formation
Olakanmi, O., McGowan, S. E., Hayek, M. B., & Britigan, B. E. (1993)
Retraction Note: Identification of a novel Na+-coupled Fe3+-citrate transport system, distinct from mammalian INDY, for uptake of citrate in mammalian cells
Ogura, J., Babu, E., Miyauchi, S., Ramachandran, S., Nemeth, E., Bhutia, Y. D., & Ganapathy, V. (2018) · Scientific Reports · doi:10.1038/s41598-018-28645-x
Retracted
Elucidating the role of Mitoferrin (Mfrn), Iron Regulatory Proteins (IRP1 and IRP2) and Hephaestin (Heph) in iron metabolism by tagSNP and Protein-Protein Interaction (PPI) analysis
Velaga, R. M. (2014) · London Met Repository (London Metropolitan University)
Régulation de l'hepcidine et le rôle de la lipocaline 2 dans l'homéostasie du fer / Novel insights into the regulation of hepcidin and the role of lipocalin 2 in iron homeostasis
Huang, H. (2013) · doi:10.71781/27807

Authors: Kaplan, J., Jordan, I., & Sturrock, A.
Affiliations: University of Utah (US)
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1991-02
Volume: 266
Issue: 5
Pages: 2997-3004
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(18)49946-2
OpenAlex: W1587837383
Cited by: 198
References: 26
Citations by year: 2026: 2 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 8 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 8 · 2012: 5
FWCI: 6.12
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 10844 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01dk020630-22)
National Institute of Diabetes and Digestive and Kidney Diseases (DK20630, DK30534)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
Keywords: iron uptake regulation, transferrin receptor, extracellular iron, copper, zinc, intracellular calcium, iron accumulation, cultured cells
MeSH terms: Biological Transport, Cadmium, Calcium, Copper, Cycloheximide, Ferritins, HeLa Cells, Humans, Iron, Manganese, Transferrin, Zinc

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Regulation of the transferrin-independent iron transport system in cultured cells.

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