Kaplan, Jerry

Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 4,803

Regulation of Mitochondrial Iron Accumulation by Yfh1p, a Putative Homolog of Frataxin

Babcock, M., de Silva, D., Oaks, R., Davis-Kaplan, S., Jiralerspong, S., Montermini, L., Pandolfo, M., & Kaplan, J. (1997) · Science

Mitochondrial Function and PathologyNeurological diseases and metabolism

Cited by 921

The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake.

Askwith, C., Eide, D., Van Ho, A., Bernard, P. S., Li, L., Davis-Kaplan, S., Sipe, D. M., & Kaplan, J. (1994) · Cell

Iron Metabolism and DisordersFungal and yeast genetics research

Cited by 670

Molecular characterization of a copper transport protein in S. cerevisiae: An unexpected role for copper in iron transport

Dancis, A., Yuan, D. S., Haile, D., Askwith, C., Eide, D., Moehle, C., Kaplan, J., & Klausner, R. D. (1994) · Cell

Trace Elements in HealthIron Metabolism and Disorders

Cited by 659

Mitoferrin is essential for erythroid iron assimilation

Shaw, G. C., Cope, J. J., Li, L., Corson, K., Hersey, C., Ackermann, G. E., Gwynn, B., Lambert, A. J., Wingert, R. A., Traver, D., et al. (2006) · Nature

Iron Metabolism and DisordersMitochondrial Function and Pathology

Cited by 624

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

Silvestri, L., Pagani, A., Nai, A., De Domenico, I., Kaplan, J., & Camaschella, C. (2008) · Cell Metabolism

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 555

Regulation of iron acquisition and storage: consequences for iron-linked disorders

De Domenico, I., McVey Ward, D., & Kaplan, J. (2008) · Nature Reviews Molecular Cell Biology

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 464

The Molecular Mechanism of Hepcidin-mediated Ferroportin Down-Regulation

De Domenico, I., Ward, D. M., Langelier, C., Vaughn, M. B., Nemeth, E., Sundquist, W. I., Ganz, T., Musci, G., & Kaplan, J. (2007) · Molecular Biology of the Cell

Iron Metabolism and DisordersCellular transport and secretion

Cited by 434

A Heme Export Protein Is Required for Red Blood Cell Differentiation and Iron Homeostasis

Keel, S. B., Doty, R. T., Yang, Z., Quigley, J. G., Chen, J., Knoblaugh, S., Kingsley, P. D., De Domenico, I., Vaughn, M. B., Kaplan, J., et al. (2008) · Science

Iron Metabolism and DisordersHemoglobin structure and function

Cited by 404

Ferroportin-mediated iron transport: Expression and regulation

Ward, D. M., & Kaplan, J. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 373

Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis.

The Tübingen 2000 Screen Consortium, Wingert, R. A., Galloway, J. L., Barut, B., Foott, H., Fraenkel, P., Axe, J. L., Weber, G. J., Dooley, K., Davidson, A. J., et al. (2005) · Nature

Iron Metabolism and DisordersHemoglobin structure and function

Cited by 370

CCC1 Is a Transporter That Mediates Vacuolar Iron Storage in Yeast

Li, L., Chen, O. S., Ward, D. M., & Kaplan, J. (2001) · Journal of Biological Chemistry

Iron Metabolism and DisordersFungal and yeast genetics research

Cited by 354

Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin

De Domenico, I., Ward, D. M., di Patti, M. C. B., Jeong, S. Y., David, S., Musci, G., & Kaplan, J. (2007) · The EMBO Journal

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 350

The Yeast Frataxin Homologue Mediates Mitochondrial Iron Efflux

Radisky, D. C., Babcock, M. C., & Kaplan, J. (1999) · Journal of Biological Chemistry

Mitochondrial Function and PathologyNeurological diseases and metabolism

Cited by 277

The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study

Nemeth, E., Preza, G. C., Jung, C.-L., Kaplan, J., Waring, A. J., & Ganz, T. (2006) · Blood

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 273

Tissue distribution and clearance kinetics of non-transferrin-bound iron in the hypotransferrinemic mouse: a rodent model for hemochromatosis

Craven, C. M., Alexander, J., Eldridge, M., Kushner, J. P., Bernstein, S., & Kaplan, J. (1987) · Proceedings of the National Academy of Sciences

Iron Metabolism and DisordersTrace Elements in Health

Cited by 259

Ferroportin‐mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome

De Domenico, I., Vaughn, M. B., Li, L., Bagley, D., Musci, G., Ward, D. M., & Kaplan, J. (2006) · The EMBO Journal

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 235

The molecular basis of ferroportin-linked hemochromatosis

De Domenico, I., Ward, D. M., Nemeth, E., Vaughn, M. B., Musci, G., Ganz, T., & Kaplan, J. (2005) · Proceedings of the National Academy of Sciences

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 230

Iron depletion limits intracellular bacterial growth in macrophages

Paradkar, P. N., De Domenico, I., Durchfort, N., Zohn, I., Kaplan, J., & Ward, D. M. (2008) · Blood

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 216

Transcription of the Yeast Iron Regulon Does Not Respond Directly to Iron but Rather to Iron-Sulfur Cluster Biosynthesis

Chen, O. S., Crisp, R. J., Valachovic, M., Bard, M., Winge, D. R., & Kaplan, J. (2004) · Journal of Biological Chemistry

Fungal and yeast genetics researchIron Metabolism and Disorders

Cited by 202

Regulation of the transferrin-independent iron transport system in cultured cells.

Kaplan, J., Jordan, I., & Sturrock, A. (1991) · Journal of Biological Chemistry

Iron Metabolism and DisordersTrace Elements in Health

Cited by 198

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice

De Domenico, I., Zhang, T. Y., Koening, C. L., Branch, R. W., London, N., Lo, E., Daynes, R. A., Kushner, J. P., Li, D., Ward, D. M., et al. (2010) · Journal of Clinical Investigation

Iron Metabolism and DisordersCytokine Signaling Pathways and Interactions

Cited by 197

Specific iron chelators determine the route of ferritin degradation

De Domenico, I., Ward, D. M., & Kaplan, J. (2009) · Blood

Iron Metabolism and DisordersAutophagy in Disease and Therapy

Cited by 176

Frataxin knockin mouse

Miranda, C. J., Santos, M. M., Ohshima, K., Smith, J., Li, L., Bunting, M., Cossée, M., Koenig, M., Sequeiros, J., Kaplan, J., et al. (2002) · FEBS Letters

Genetic Neurodegenerative DiseasesNeurological diseases and metabolism

Cited by 172