Cited by 273Cardiac Ischemia and ReperfusionCardiac electrophysiology and arrhythmiasRedox biology and oxidative stress

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes

Open access

Josephson, R A, Silverman, H S, Lakatta, E G, Stern, M D, Zweier, J L·1991·Journal of Biological Chemistry

Open this paper in CoChat — free account

Abstract

There is evidence that myocardial injury, as would occur on post-ischemic reperfusion, may be caused by the generation of oxygen radicals, as well as by the induction of intracellular calcium overload; however, the relationship between these two mechanisms of injury is not known. To test the hypothesis that oxidants and oxygen radicals can cause cardiac myocyte injury and intracellular calcium overload, isolated adult rat ventricular myocytes were exposed to H2O2 (1-10 mM) and Fe3(+)-nitrilotriacetate. EPR measurements confirmed the production of the highly reactive .OH radical by this system. The oxygen radical generating system initially caused a transient augmentation of twitch amplitude in single field stimulated myocytes. This was followed by contractile oscillations occurring during the twitch prior to full cell relaxation, and spontaneous mechanical oscillations occurring between electrically stimulated contractions. Eventually, cells became inexcitable and abruptly underwent contracture. In the presence of lower bathing calcium concentrations, these oxidant-induced alterations were prevented or delayed. However, cells exposed to the radical generating system in the absence of extracellular calcium still eventually underwent contracture but stimulated contractions or mechanical oscillations were not seen. Measurements in single myocytes loaded with the fluorescent probe of intracellular calcium, Indo-1, demonstrated a rise in both systolic and diastolic fluorescence ratio, as well as oscillations and widening of the fluorescence transient, suggestive of cellular calcium loading, following exposure to the radical generating system. Injured myocytes did not take up trypan blue dye. Contractile dysfunction and calcium channel blocker, nitrendipine. NMR measurements of cellular [ATP] demonstrated that these alterations in cellular calcium preceded the depletion of ATP. Subsequent depletion of ATP was accompanied by the appearance of increased concentrations of sugar phosphates indicative of a block in glycolysis and ATP depletion correlated with cellular rigor. Thus, oxygen free radicals can cause cardiac myocyte injury with contractile abnormalities which occur due to myocyte calcium loading. The mechanism of oxidant-induced calcium loading is not due to nonspecific membrane damage, or energy depletion, but rather due to increased calcium influx through voltage gated calcium channels. This early calcium overload state as well as oxidant induced block of glycolysis result in cellular energy depletion and cell death with the induction of contracture.

Integrity signals

Registry

Crossref · 10.1016/s0021-9258(18)52251-1

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Oxygen radicals and human disease
CROSS, C. E., HALLIWELL, B., BORISH, E. T., PRYOR, W. A., AMES, B. N., SAUL, R. L., McCORD, J. M., & HARMAN, D. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-526 · Cited by 1,856
Spin Trapping: ESR parameters of spin adducts 1474 1528V
Buettner, G. R. (1987) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(87)80033-3 · Cited by 1,827
Direct measurement of free radical generation following reperfusion of ischemic myocardium.
Zweier, J. L., Flaherty, J. T., & Weisfeldt, M. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.5.1404 · Cited by 1,189
Self-citation
Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.
Jolly, S., Kane, W. J., Bailie, M. B., Abrams, G. D., & Lucchesi, B. R. (1984) · Circulation Research · doi:10.1161/01.res.54.3.277 · Cited by 900
Cooperation within Actin Filament in Vertebrate Skeletal Muscle
Bremel, R. D., & Weber, A. (1972) · Nature New Biology · doi:10.1038/newbio238097a0 · Cited by 700
Xanthine oxidase as a source of free radical damage in myocardial ischemia
CHAMBERS, D., PARKS, D., PATTERSON, G., ROY, R., MCCORD, J., YOSHIDA, S., PARMLEY, L., & DOWNEY, J. (1985) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(85)80017-1 · Cited by 672
Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.
Zweier, J. L. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57309-4 · Cited by 634
Self-citation
Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy.
Garlick, P. B., Davies, M. J., Hearse, D. J., & Slater, T. F. (1987) · Circulation Research · doi:10.1161/01.res.61.5.757 · Cited by 625
Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide.
Hyslop, P. A., Hinshaw, D. B., Halsey, W. A., Schraufstätter, I. U., Sauerheber, R., Spragg, R. G., Jackson, J. H., & Cochrane, C. G. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77928-9 · Cited by 616
Stoichiometric and site characteristics of the binding of iron to human transferrin
Aisen, P., Leibman, A., & Zweier, J. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)62337-9 · Cited by 601
Self-citation

Show all 31 references

Research works printed but not linked: 6

Murphy, 1987, Circulation, 75, V-15
Weiss, 1990, J. Clin. Invest.
Spurgeon, 1990, Am. J. Physiol., 258, H574
Silver, 1983, Am. J. Physiol., 245, H891
Stuart, 1989, Biophys. J., 55, 15a
Bremel, 1972, Nature, 238, 97

Sorted by citations

The role of oxidants and free radicals in reperfusion injury
Zweier, J. L., & Talukder, M. F. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.02.025 · Cited by 743
Self-citation
Mitochondrial Electron Transport Complex I Is a Potential Source of Oxygen Free Radicals in the Failing Myocardium
Ide, T., Tsutsui, H., Kinugawa, S., Utsumi, H., Kang, D., Hattori, N., Uchida, K., Arimura, K., Egashira, K., & Takeshita, A. (1999) · Circulation Research · doi:10.1161/01.res.85.4.357 · Cited by 702
Interaction of reactive oxygen species with ion transport mechanisms
Kourie, J. I. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.275.1.c1 · Cited by 638
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541
Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow.
Ambrosio, G., Zweier, J. L., Duilio, C., Kuppusamy, P., Santoro, G., Elia, P. P., Tritto, I., Cirillo, P. L., Condorelli, M., & Chiariello, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46660-9 · Cited by 515
Self-citation
Calcium-Mediated Mechanisms in Chemically Induced Cell Death
Nicotera, P., Bellomo, G., & Orrenius, S. (1992) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.32.040192.002313 · Cited by 519
Big Mitogen-activated Protein Kinase 1 (BMK1) Is a Redox-sensitive Kinase
Abe, J., Kusuhara, M., Ulevitch, R. J., Berk, B. C., & Lee, J.-D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.28.16586 · Cited by 441
Direct Evidence for Increased Hydroxyl Radicals Originating From Superoxide in the Failing Myocardium
Ide, T., Tsutsui, H., Kinugawa, S., Suematsu, N., Hayashidani, S., Ichikawa, K., Utsumi, H., Machida, Y., Egashira, K., & Takeshita, A. (2000) · Circulation Research · doi:10.1161/01.res.86.2.152 · Cited by 427
Reactive Oxygen Species, Mitochondria, and NAD(P)H Oxidases in the Development and Progression of Heart Failure
Sorescu, D., & Griendling, K. K. (2002) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2002.00717.x · Cited by 403
The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion
Raedschelders, K., Ansley, D. M., & Chen, D. D. Y. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.11.004 · Cited by 393
Treatment With Dimethylthiourea Prevents Left Ventricular Remodeling and Failure After Experimental Myocardial Infarction in Mice
Kinugawa, S., Tsutsui, H., Hayashidani, S., Ide, T., Suematsu, N., Satoh, S., Utsumi, H., & Takeshita, A. (2000) · Circulation Research · doi:10.1161/01.res.87.5.392 · Cited by 323
Stimulation of “Stress-regulated” Mitogen-activated Protein Kinases (Stress-activated Protein Kinases/c-Jun N-terminal Kinases and p38-Mitogen-activated Protein Kinases) in Perfused Rat Hearts by Oxidative and Other Stresses
Clerk, A., Fuller, S. J., Michael, A., & Sugden, P. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.13.7228 · Cited by 314
Carvedilol Decreases Elevated Oxidative Stress in Human Failing Myocardium
Nakamura, K., Kusano, K., Nakamura, Y., Kakishita, M., Ohta, K., Nagase, S., Yamamoto, M., Miyaji, K., Saito, H., Morita, H., et al. (2002) · Circulation · doi:10.1161/01.cir.0000018605.14470.dd · Cited by 291
Post-infarct remodelling: contribution of wound healing and inflammation
Frantz, S., Bauersachs, J. K., & Ertl, G. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn292 · Cited by 298
Reactive Oxygen Species–Activated Ca/Calmodulin Kinase IIδ Is Required for Late I Na Augmentation Leading to Cellular Na and Ca Overload
Wagner, S., Ruff, H. M., Weber, S. L., Bellmann, S., Sowa, T., Schulte, T., Anderson, M. E., Grandi, E., Bers, D. M., Backs, J., et al. (2011) · Circulation Research · doi:10.1161/circresaha.110.221911 · Cited by 278
Hydroxyl Radical Inhibits Sarcoplasmic Reticulum Ca2+-ATPase Function by Direct Attack on the ATP Binding Site
Xu, K. Y., Zweier, J. L., & Becker, L. C. (1997) · Circulation Research · doi:10.1161/01.res.80.1.76 · Cited by 271
Self-citation
Oxidant-induced Activation of Type I Protein Kinase A Is Mediated by RI Subunit Interprotein Disulfide Bond Formation
Brennan, J. P., Bardswell, S. C., Burgoyne, J. R., Fuller, W., Schröder, E., Wait, R., Begum, S., Kentish, J. C., & Eaton, P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603952200 · Cited by 252
Nox2 NADPH Oxidase Promotes Pathologic Cardiac Remodeling Associated with Doxorubicin Chemotherapy
Zhao, Y., McLaughlin, D., Robinson, E., Harvey, A., Hookham, M. B., Shah, A. M., McDermott, B. J., & Grieve, D. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2664 · Cited by 245
Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation.
Zweier, J. L., Broderick, R., Kuppusamy, P., Thompson-Gorman, S. L., & Lutty, G. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)51062-6 · Cited by 244
Self-citation
Glucose-6-Phosphate Dehydrogenase Modulates Cytosolic Redox Status and Contractile Phenotype in Adult Cardiomyocytes
Jain, M., Brenner, D. A., Cui, L., Lim, C. C., Wang, B., Pimentel, D. R., Koh, S. G., Sawyer, D. B., Leopold, J. A., Handy, D. E., et al. (2003) · Circulation Research · doi:10.1161/01.res.0000083489.83704.76 · Cited by 204
Oxygen free radicals and cardiac reperfusion abnormalities.
Goldhaber, J. I., & Weiss, J. N. (1992) · Hypertension · doi:10.1161/01.hyp.20.1.118 · Cited by 191
Vascular Malformations and Epilepsy: Clinical Considerations and Basic Mechanisms
Kraemer, D. L. A., & Awad, I. A. (1994) · Epilepsia · doi:10.1111/j.1528-1157.1994.tb05987.x · Cited by 170
Reactive oxygen species and silica‐induced carcinogenesis
Shi, X., Castranova, V., Halliwell, B. B., & Vallyathan, V. (1998) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937409809524551 · Cited by 172
Signaling Role of Intracellular Iron in NF-κB Activation
Xiong, S., She, H., Takeuchi, H., Han, B., Engelhardt, J. F., Barton, C. H., Zandi, E., Giulivi, C., & Tsukamoto, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210905200 · Cited by 161
Hydrogen peroxide and superoxide modulate leukocyte adhesion molecule expression and leukocyte endothelial adhesion
Fraticelli, A., Junior, C. V. S., Bochner, B. S., Capogrossi, M. C., & Zweier, J. L. (1996) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(95)00169-7 · Cited by 156
Self-citation
Cellular Mechanisms Of Myocardial Stunning
Kusuoka, H., & Marbán, E. (1992) · Annual Review of Physiology · doi:10.1146/annurev.ph.54.030192.001331 · Cited by 153
Selective Effects of Oxygen Free Radicals on Excitation-Contraction Coupling in Ventricular Muscle
Gao, W. D., Liu, Y., & Marbán, E. (1996) · Circulation · doi:10.1161/01.cir.94.10.2597 · Cited by 152
Involvement of the Nicotinamide Adenosine Dinucleotide Phosphate Oxidase Isoform Nox2 in Cardiac Contractile Dysfunction Occurring in Response to Pressure Overload
Grieve, D., Byrne, J., Siva, A., Layland, J., Johar, S., Cave, A. C., & Shah, A. M. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.09.051 · Cited by 148
NADPH oxidase signaling and cardiac myocyte function
Akki, A. S., Zhang, M., Murdoch, C. E., Brewer, A. C., & Shah, A. M. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.04.004 · Cited by 143
Propofol Attenuates Hydrogen Peroxide-induced Mechanical and Metabolic Derangements in the Isolated Rat Heart
Kokita, N., & Hara, A. (1996) · Anesthesiology · doi:10.1097/00000542-199601000-00014 · Cited by 142
Creatine Kinase Is the Main Target of Reactive Oxygen Species in Cardiac Myofibrils
Mekhfi, H., Veksler, V., Matéo, P., Maupoil, V., Rochette, L., & Ventura‐Clapier, R. (1996) · Circulation Research · doi:10.1161/01.res.78.6.1016 · Cited by 134
Redox-mediated reciprocal regulation of SERCA and Na+–Ca2+ exchanger contributes to sarcoplasmic reticulum Ca2+ depletion in cardiac myocytes
Kuster, G. M., Lancel, S., Zhang, J., Communal, C., Trucillo, M. P., Lim, C. C., Pfister, O., Weinberg, E. O., Cohen, R. A., Liao, R., et al. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.01.038 · Cited by 132
Propofol Attenuates Ischemia-Reperfusion Injury in the Isolated Rat Heart
Ko, S., Yu, C.-W., Lee, S. K., Choe, H., Chung, M., Kwak, Y., Chae, S., & Song, H. S. (1997) · Anesthesia & Analgesia · doi:10.1097/00000539-199710000-00002 · Cited by 132
Effect of β-Blockers on Free Radical–Induced Cardiac Contractile Dysfunction
Flesch, M., Maack, C., Cremers, B., Bäumer, A. T., Südkamp, M., & Böhm, M. (1999) · Circulation · doi:10.1161/01.cir.100.4.346 · Cited by 123
Polycyclic Aromatic Hydrocarbon (PAH) o-Quinones Produced by the Aldo-Keto-Reductases (AKRs) Generate Abasic Sites, Oxidized Pyrimidines, and 8-Oxo-dGuo via Reactive Oxygen Species
Park, J., Troxel, A. B., Harvey, R. G., & Penning, T. M. (2006) · Chemical Research in Toxicology · doi:10.1021/tx0600245 · Cited by 120
Reactive oxygen and nitrogen species regulate inducible nitric oxide synthase function shifting the balance of nitric oxide and superoxide production
Sun, J., Druhan, L. J., & Zweier, J. L. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2009.11.019 · Cited by 122
Self-citation
Hydrogen Peroxide Dose Dependent Induction of Cell Death or Hypertrophy in Cardiomyocytes
Chen, Q. M., Tu, V. C., Wu, Y., & Bahl, J. J. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1558 · Cited by 119
Glycolytic inhibition and calcium overload as consequences of exogenously generated free radicals in rabbit hearts.
Corretti, M. C., Koretsune, Y., Kusuoka, H., Chacko, V. P., Zweier, J. L., & Marbán, E. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115361 · Cited by 113
Self-citation
Mechanism of oxidative stress‐induced intracellular acidosis in rat cerebellar astrocytes and C6 glioma cells
Tsai, K.-L., Wang, S., Chen, C., Fong, T.-H., & Wu, M. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.161bl.x · Cited by 106
Possible use of quercetin, an antioxidant, for protection of cells suffering from overload of intracellular Ca2+: A model experiment
Sakanashi, Y., Oyama, K., Matsui, H., Oyama, T. B., Oyama, T. M., Nishimura, Y. H., Sakai, H., & Oyama, Y. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.05.009 · Cited by 101
Excitation‐contraction coupling in single guinea‐pig ventricular myocytes exposed to hydrogen peroxide.
Goldhaber, J. I., & Liu, E. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020178 · Cited by 97
H2O2-induced Ca2+overload in NRVM involves ERK1/2 MAP kinases: role for an NHE-1-dependent pathway
Rothstein, E. C., Byron, K. L., Reed, R. E., Fliegel, L., & Lucchesi, P. A. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00198.2002 · Cited by 96
Oxygen free radicals and calcium homeostasis in the heart
Kaneko, M., Matsumoto, Y., Hayashi, H., Kobayashi, A., & Yamazaki, N. (1994) · Molecular and Cellular Biochemistry · doi:10.1007/bf00944207 · Cited by 96
Pretreatment with antioxidants and allopurinol diminishes cardiac onset events in coronary artery bypass grafting
Sisto, T., Paajanen, H., Metsä‐Ketelä, T., Harmoinen, A. P. T., NORDBACK, I. H., & Tarkka, M. R. (1995) · The Annals of Thoracic Surgery · doi:10.1016/0003-4975(95)00197-s · Cited by 95
Hydroxyl Radical-Induced Acute Diastolic Dysfunction Is Due to Calcium Overload via Reverse-Mode Na + -Ca 2+ Exchange
Zeitz, O., Maass, A. E., Văn, P. N., Hensmann, G., Kögler, H., Möller, K., Hasenfuss, G. P., & Janssen, P. M. L. (2002) · Circulation Research · doi:10.1161/01.res.0000018625.25212.1e · Cited by 95
Evaluation of the role of polymorphonuclear leukocytes on contractile function in myocardial reperfusion injury. Evidence for plasma-mediated leukocyte activation.
Shandelya, S. M., Kuppusamy, P., Weisfeldt, M. L., & Zweier, J. L. (1993) · Circulation · doi:10.1161/01.cir.87.2.536 · Cited by 94
Self-citation
Involvement of NADPH Oxidases in Cardiac Remodelling and Heart Failure
Sirker, A. A., Zhang, M., Murdoch, C. E., & Shah, A. M. (2007) · American Journal of Nephrology · doi:10.1159/000109148 · Cited by 93
Superoxide, hydroxyl radical, and hydrogen peroxide effects on single-diaphragm fiber contractile apparatus
Callahan, L. A., She, Z. W., & Nosek, T. M. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.1.45 · Cited by 91
Calpain system and its involvement in myocardial ischemia and reperfusion injury
Neuhof, C. (2014) · World Journal of Cardiology · doi:10.4330/wjc.v6.i7.638 · Cited by 85
Amiodarone Protects Cardiac Myocytes Against Oxidative Injury by its Free Radical Scavenging Action
Ide, T., Tsutsui, H., Kinugawa, S., Utsumi, H., & Takeshita, A. (1999) · Circulation · doi:10.1161/01.cir.100.7.690 · Cited by 81
Mitochondrial Function In Ischaemia And Reperfusion Of The Ageing Heart
Pepe, S. (2000) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2000.03326.x · Cited by 80
Electrophysiological Effects of 4-Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, on Isolated Rat Ventricular Myocytes
Bhatnagar, A. (1995) · Circulation Research · doi:10.1161/01.res.76.2.293 · Cited by 80
Revealing silver cytotoxicity using Au nanorods/Ag shell nanostructures: disrupting cell membrane and causing apoptosis through oxidative damage
Cheng, X., Zhang, W., Ji, Y., Meng, J., Guo, H., Liu, J., Wu, X., & Xu, H. (2012) · RSC Advances · doi:10.1039/c2ra23131j · Cited by 78
Diving seals, ischemia-reperfusion and oxygen radicals
Elsner, R., Øyasæter, S., Almaas, R., & Saugstad, O. D. (1998) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(98)00012-9 · Cited by 78
Direct detection of endogenous hydroxyl radical production in cultured adult cardiomyocytes during anoxia and reoxygenation. Is the hydroxyl radical really the most damaging radical species?
Khalid, M. A., & Ashraf, M. (1993) · Circulation Research · doi:10.1161/01.res.72.4.725 · Cited by 78
Beta-Blockers and Oxidative Stress in Patients with Heart Failure
Nakamura, K., Murakami, M., Miura, D., Yunoki, K., Enko, K., Tanaka, M., Saito, Y., Nishii, N., Miyoshi, T., Yoshida, M., et al. (2011) · Pharmaceuticals · doi:10.3390/ph4081088 · Cited by 76
Relationship Between Oxidative Stress and Systolic Dysfunction in Patients With Hypertrophic Cardiomyopathy
Nakamura, K., KUSANO, K. F., Matsubara, H., Nakamura, Y., Miura, A., Nishii, N., Banba, K., Nagase, S., Miyaji, K., Morita, H., et al. (2005) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2004.05.005 · Cited by 75
Antioxidant properties of myocardial fuels
Mallet, R. T., & Sun, J. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1026009519783 · Cited by 74
Neuroprotection by Manganese Superoxide Dismutase ( M n SOD ) Mimics: Antioxidant Effect and Oxidative Stress Regulation in Acute Experimental Stroke
Huang, H., Guo, F., Cao, Y., Shi, W., & Xia, Q. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2012.00380.x · Cited by 73
Effect of dietary polyunsaturated fatty acids on age-related changes in cardiac mitochondrial membranes
Pepe, S. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.03.013 · Cited by 74
Mechanism of Hydrogen Peroxide and Hydroxyl Free Radical–Induced Intracellular Acidification in Cultured Rat Cardiac Myoblasts
Wu, M. L., Tsai, K.-L., Wang, S., Wu, J., Wang, B.-S., & Lee, Y. (1996) · Circulation Research · doi:10.1161/01.res.78.4.564 · Cited by 74
Differential MAP kinase activation and Na+/H+exchanger phosphorylation by H2O2 in rat cardiac myocytes
Wei, S., Rothstein, E. C., Fliegel, L., Dell’Italia, L. J., & Lucchesi, P. A. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.5.c1542 · Cited by 74
The Role of SUMO-1 in Cardiac Oxidative Stress and Hypertrophy
Lee, A., Jeong, D., Mitsuyama, S., Oh, J. G., Liang, L., Ikeda, Y., Sadoshima, J., Hajjar, R. J., & Kho, C. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5983 · Cited by 71
Pathophysiology and Mediators of Ischemia-Reperfusion Injury with Special Reference to Cardiac Surgery: A Review
Vaage, J., & Valen, G. (1993) · Scandinavian Journal of Thoracic and Cardiovascular Surgery · doi:10.3109/14017439309100154 · Cited by 69
Sulfhydryls associated with H2O2-induced channel activation are on luminal side of ryanodine receptors
Ôba, T., Ishikawa, T., & Yamaguchi, M. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.4.c914 · Cited by 68
Heart Failure, Oxidative Stress, and Ion Channel Modulation
Choudhary, G., & Dudley, S. C. (2002) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2002.00716.x · Cited by 67
Studies of hypoxemic/reoxygenation injury: Without aortic clamping:
Morita, K., Ihnken, K. A., Buckberg, G. D., & Young, H. (1995) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(95)70008-0 · Cited by 67
Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart
Reyes, L. A., Boslett, J. J., Varadharaj, S., Pascali, F. D., Hemann, C. F., Druhan, L. J., Ambrosio, G., El‐Mahdy, M. A., & Zweier, J. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1505556112 · Cited by 65
Self-citation
Role of Renal Oxidative Stress in the Pathogenesis of the Cardiorenal Syndrome
Giam, B., Kaye, D. M., & Rajapakse, N. W. (2016) · Heart Lung and Circulation · doi:10.1016/j.hlc.2016.02.022 · Cited by 65
In vivo imaging of free radicals: Applications from mouse to man
He, G., Samouilov, A., Kuppusamy, P., & Zweier, J. L. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1015994629341 · Cited by 64
Self-citation
Oxidative Stress and Cardiovascular Complications in Chronic Kidney Disease, the Impact of Anaemia
Nuhu, F., & Bhandari, S. (2018) · Pharmaceuticals · doi:10.3390/ph11040103 · Cited by 64
Na+–Ca2+ exchanger overexpression predisposes to reactive oxygen species-induced injury
Wagner, S. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.08.006 · Cited by 61
Redox Control of Cardiac Excitability
Aggarwal, N. T., & Makielski, J. C. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4234 · Cited by 62
Greater susceptibility of failing cardiac myocytes to oxygen free radical-mediated injury
Tsutsui, H. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00197-8 · Cited by 59
Free radical involvement in doxorubicin-induced electrophysiological alterations in rat papillary muscle fibres
Venditti, P. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00034-0 · Cited by 57
Glutathione is a Cofactor for H2O2-Mediated Stimulation of Ca2+-Induced Ca2+ Release in Cardiac Myocytes
Suzuki, Y., Cleemann, L. N., Abernethy, D. R., & Morad, M. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00227-x · Cited by 57
Cytosolic Ca2+ movements of endothelial cells exposed to reactive oxygen intermediates: Role of hydroxyl radical‐mediated redox alteration of cell‐membrane Ca2+ channels
Azma, T., Saeki, N., & Yuge, O. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702438 · Cited by 56
Reactive oxygen species activate the group IV muscle afferents in resting and exercising muscle in rats
Delliaux, S., Brerro‐Saby, C., Steinberg, J. G., & Jammes, Y. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0713-8 · Cited by 55
Dietary fish oil alters cardiomyocyte Ca2+ dynamics and antioxidant status
Jahangiri, A., Leifert, W. R., Kind, K. L., & McMurchie, E. J. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.12.026 · Cited by 55
Potential roles of myoglobin autoxidation in myocardial ischemia-reperfusion injury
Gunther, M. R., Sampath, V., & Caughey, W. S. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00338-4 · Cited by 55
4-Hydroxy-2-nonenal Induces Calcium Overload via the Generation of Reactive Oxygen Species in Isolated Rat Cardiac Myocytes
Nakamura, K., Miura, D., KUSANO, K. F., Fujimoto, Y., Yoshikawa, W. S., Fuke, S., Nishii, N., Nagase, S., Hata, Y., Morita, H., et al. (2009) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2009.04.008 · Cited by 51
Left ventricular remodeling after myocardial infarction in mice with targeted deletion of the NADPH oxidase subunit gp91PHOX
Frantz, S., Brandes, R. P., Hu, K., Rammelt, K., Wolf, J., Scheuermann, H., Ertl, G., & Bauersachs, J. K. (2005) · Basic Research in Cardiology · doi:10.1007/s00395-005-0568-x · Cited by 52
Clinical Potential of Sodium-Calcium Exchanger Inhibitors as Antiarrhythmic Agents
Pogwizd, S. M. (2003) · Drugs · doi:10.2165/00003495-200363050-00001 · Cited by 51
Oxygen-Derived Free Radical-Induced Vasoconstriction by Thromboxane A2 in Aorta of the Spontaneously Hypertensive Rat
Hibino, M., Okumura, K., Iwama, Y., Mokuno, S., Osanai, H., Matsui, H., Toki, Y., & Ito, T. (1999) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199904000-00013 · Cited by 51
Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase
Sun, J., Druhan, L. J., & Zweier, J. L. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.01.003 · Cited by 47
Self-citation
Measurement of carvedilol in plasma by high-performance liquid chromatography with electrochemical detection
Machida, M., Watanabe, M., Takechi, S., Kakinoki, S., & Nomura, A. (2003) · Journal of Chromatography B · doi:10.1016/j.jchromb.2003.09.039 · Cited by 47
Salvia miltiorrhiza attenuates the changes in contraction and intracellular calcium induced by anoxia and reoxygenation in rat cardiomyocytes
Cao, C., Xia, Q., Zhang, X., Xu, W.-H., Jiang, H., & Chen, J.-Z. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00142-5 · Cited by 47
Effect of extracellular Mg2+on ROS and Ca2+accumulation during reoxygenation of rat cardiomyocytes
Sharikabad, M. N., Østbye, K. M., Lyberg, T., & Brørs, O. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.1.h344 · Cited by 47
Propofol attenuation of hydrogen peroxide-mediated oxidative stress and apoptosis in cultured cardiomyocytes involves haeme oxygenase-1
Xu, J., & Wang, Y.-L. (2008) · European Journal of Anaesthesiology · doi:10.1017/s0265021508003542 · Cited by 46
Contractile and morphological impairment of cultured fetal mouse myocytes induced by oxygen radicals and oxidants. Correlation with intracellular Ca2+ concentration.
Nakamura, T. Y., Goda, K., Okamoto, T., Kishi, T., Nakamura, T., & Goshima, K. (1993) · Circulation Research · doi:10.1161/01.res.73.4.758 · Cited by 46
Influx of Calcium through a Redox-sensitive Plasma Membrane Channel in Thymocytes Causes Early Necrotic Cell Death Induced by the Epipolythiodioxopiperazine Toxins
Hurne, A. M., Chai, C. L. L., Moerman, K., & Waring, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201699200 · Cited by 46
Nitroxyl enhances myocyte Ca2 transients by exclusively targeting SR Ca2 -cycling
Kohr, M. J. (2010) · Frontiers in Bioscience-Elite · doi:10.2741/e118 · Cited by 43
Activation of the Ste20-like Oxidant Stress Response Kinase-1 during the Initial Stages of Chemical Anoxia-induced Necrotic Cell Death
Pombo, C. M., Tsujita, T., Kyriakis, J. M., Bonventre, J. V., & Force, T. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.46.29372 · Cited by 43
Molecular Mechanisms of Cardiac Hypertrophy Induced by Toxicants
Chen, Q. M., Tu, V. C., Purdom, S., Wood, J. R., & Dilley, T. (2001) · Cardiovascular Toxicology · doi:10.1385/ct:1:4:267 · Cited by 43
Transient and sustained impacts of hydroxyl radicals on sarcoplasmic reticulum function: protective effects of nebivolol
Janssen, P. M. L., Zeitz, O., & Hasenfuss, G. P. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00907-8 · Cited by 43
Chemiluminometric determination of carvedilol in a multi-pumping flow system
Pires, C. K., Marques, K. L., Santos, J. L. M., Lapa, R. A. S., Lima, J. L. F. C., & Zagatto, E. A. G. (2005) · Talanta · doi:10.1016/j.talanta.2005.07.006 · Cited by 42
Role of Reactive Oxygen Species on Diesel Exhaust Particle-Induced Cytotoxicity in Rat Cardiac Myocytes
Okayama, Y., Kuwahara, M., Suzuki, A. K., & Tsubone, H. (2006) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390600631078 · Cited by 42
Superoxide and hydrogen peroxide induce CD18-mediated adhesion in the postischemic heart
Junior, C. V. S., Mikhail, E. A., Wang, P., Noble, B., Kuppusamy, P., & Zweier, J. L. (1996) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(96)00025-7 · Cited by 42
Self-citation
Maternal obesity impairs fetal cardiomyocyte contractile function in sheep
Wang, Q., Zhu, C., Sun, M., Rexiati, M., Ford, S. P., Nathanielsz, P. W., Ren, J. T., & Guo, W. (2018) · The FASEB Journal · doi:10.1096/fj.201800988r · Cited by 41
Mechanisms of Hydrogen Peroxide—Induced Increase in Intracellular Calcium in Cardiomyocytes
Wang, X., Takeda, S., Mochizuki, S., Jindal, R., & Dhalla, N. S. (1999) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/107424849900400107 · Cited by 41

Authors: Josephson, R. A., Silverman, H. S., Lakatta, E. G., Stern, M. D., & Zweier, J. L.
Affiliations: Johns Hopkins University (US)
ORCID: Josephson, R A
Lakatta, E G
Stern, M D
Zweier, J L
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1991-02
Volume: 266
Issue: 4
Pages: 2354-2361
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(18)52251-1
OpenAlex: W1556814137
Cited by: 272
References: 31
Citations by year: 2024: 2 · 2023: 5 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 2 · 2015: 8 · 2014: 4 · 2013: 8 · 2012: 11
FWCI: 12.04
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 10845 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p50hl017655-17)
National Heart, Lung, and Blood Institute (HL-38324, HL-07227, HL-17655-13)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: hydrogen peroxide, hydroxyl radicals, oxygen free radicals, calcium overload, cardiomyocytes, myocardial injury, contractile dysfunction, calcium influx, voltage-gated calcium channels, ATP depletion, cell death, nitrendipine
MeSH terms: Adenosine Triphosphate, Animals, Calcium, Electric Stimulation, Electron Spin Resonance Spectroscopy, Ferric Compounds, Free Radicals, Hydrogen Peroxide, Hydrogen-Ion Concentration, Hydroxides, Kinetics, Male, Myocardial Contraction, Myocardium, Nitrilotriacetic Acid, Magnetic Resonance Spectroscopy, Rats, Inbred Strains, Hydroxyl Radical, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks