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Cited by 398

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Human plasma platelet-activating factor acetylhydrolase. Association with lipoprotein particles and role in the degradation of platelet-activating factor.

Open access
Stafforini, D.M., McIntyre, T.M., Carter, M.E., Prescott, S.M.·1987·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(18)61335-3
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Abstract

Platelet-activating factor (PAF) is a bioactive phospholipid (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) synthesized by a variety of mammalian cell types. PAF induces hypotension, and activates neutrophils and platelets, among other actions. Removal of the acetyl moiety abolishes biological activity, so this reaction may regulate the concentration of PAF and its physiological effects. We have studied the significance of this reaction, which is catalyzed in vitro by an acetylhydrolase present in mammalian plasma, blood cells, and tissues. We have shown that the plasma PAF-acetylhydrolase is responsible for the degradation of PAF in whole human blood and that alternate pathways for PAF degradation in plasma or blood cells are negligible. Human plasma PAF-acetylhydrolase is associated with low and high density lipoproteins (LDL and HDL with apoE). We have confirmed that the activity is a stable component of these particles by density gradient ultracentrifugation, chromatography on heparin-agarose, and immunoprecipitation. The LDL-associated activity accounts for most or all of the PAF degradation that occurs in plasma ex vivo, while the HDL-associated activity contributes little to this process. However, the two activities likely are due to a single protein since the HDL- and LDL-associated PAF-acetylhydrolase activities can transfer from one lipoprotein to the other. These transfer processes are pH-dependent and specific, since they only occur from LDL to a well characterized subclass of HDL (apoE-containing HDL) and vice versa. We discuss the equilibrium between the two particles and the role that this process may have in vivo.

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Metadata

Authors
Stafforini, D. M., McIntyre, T. M., Carter, M. E., & Prescott, S. M.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1987-03
Volume
262
Issue
9
Pages
4215-4222
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(18)61335-3
OpenAlex
W1547302919
Cited by
398
References
26
FWCI
8.59
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Human plasma platelet-activating factor acetylhydrolase. Association with lipoprotein particles and role in the degradation of platelet-activating factor. https://app.cochat.ai/papers/10.1016/s0021-9258(18)61335-3
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Stafforini, D. M., McIntyre, T. M., Carter, M. E., & Prescott, S. M. (1987). Human plasma platelet-activating factor acetylhydrolase. Association with lipoprotein particles and role in the degradation of platelet-activating factor. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)61335-3

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.