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LEUKOCYTE-DEPENDENT HISTAMINE RELEASE FROM RABBIT PLATELETS
Open accessAbstract
We have studied the leukocyte-dependent mechanism of histamine release (LDHR) from rabbit platelets, a complement-independent mechanism which has been implicated in the deposition of immune complexes in acute serum sickness of rabbits. It was found by chromatography and passive transfer of serum from immunized rabbits that the antibody responsible for the LDHR was of IgE type. By electron microscope study of the reaction, the leukocyte involved in agglutination of platelets and release of their histamine content was identified as the basophil. Upon addition of antigen, basophils sensitized with IgE degranulated, released their histamine content and a platelet-activating factor (PAF) that caused aggregation of platelets and release of their histamine. Conditions of preparing and preserving PAF activity and some properties of this factor have been elucidated. LDHR must, therefore, be considered as an immediate hypersensitivity-type mechanism which may link allergic reactions with immunologic disease associated with severe structural injury.
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Citations
Cited by
Watson, A. D. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r600022-jlr200 · Cited by 455
Stafforini, D. M., McIntyre, T. M., Carter, M. E., & Prescott, S. M. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61335-3 · Cited by 398
Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice
Ishii, S., & Shimizu, T. (2000) · Progress in Lipid Research · doi:10.1016/s0163-7827(99)00016-8 · Cited by 384
Role of Platelet-Activating Factor in Cardiovascular Pathophysiology
Montrucchio, G., Alloatti, G., & Camussi, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1669 · Cited by 371
Mechanisms of exocytosis in phagocytic inflammatory cells. Parke-Davis Award Lecture.
(1980) · PubMed Central · Cited by 87
Metadata
- Authors
- Benveniste, J., Henson, P. M., & Cochrane, C. G.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1972-12-01
- Volume
- 136
- Issue
- 6
- Pages
- 1356-1377
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2134674910
- Cited by
- 1,218
- References
- 0
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: LEUKOCYTE-DEPENDENT HISTAMINE RELEASE FROM RABBIT PLATELETS. https://app.cochat.ai/papers/10.1084/jem.136.6.1356
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- Benveniste, J., Henson, P. M., & Cochrane, C. G. (1972). LEUKOCYTE-DEPENDENT HISTAMINE RELEASE FROM RABBIT PLATELETS. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.136.6.1356
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
