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Cited by 279

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Determination of Guanosine 3',5'-Monophosphate in Tissues and of Guanyl Cyclase in Rat Intestine

Open access
Ishikawa, Eiji, Ishikawa, Setsuko, Davis, James W., Sutherland, Earl W.·1969·Journal of Biological Chemistry

Abstract

Abstract A method for the assay of cyclic guanosine 3',5'-monophosphate has been applied to the determination of the nucleotide in tissues. Concentrations of cyclic GMP were determined in various tissues from several animal phyla. These levels were in most cases much lower than cyclic AMP, but an insect, the cricket, contained more cyclic GMP than cyclic AMP. Cyclic GMP was found in all rat tissues examined, and the upper small intestine contained relatively large amounts. The contents of the small intestine also were found to contain cyclic GMP, with that from the lower part containing more. Theophylline, an inhibitor of cyclic nucleotide phosphodiesterase, elevated the level of cyclic GMP in rat small intestine. This suggests a rapid turnover of the nucleotide in this tissue. An enzyme system which catalyzed the formation of cyclic GMP from GTP was demonstrated in small intestine. This enzyme required Mn++ for maximal activity and was inhibited by ATP. It was apparently different from adenyl cyclase.

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Metadata

Authors
Ishikawa, E., Ishikawa, S., Davis, J. W., & Sutherland, E. W.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1969-12
Volume
244
Issue
23
Pages
6371-6376
ISSN
0021-9258 (ISSN-L)
OpenAlex
W1582521124
Cited by
279
References
8
FWCI
12.29
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Determination of Guanosine 3',5'-Monophosphate in Tissues and of Guanyl Cyclase in Rat Intestine. https://app.cochat.ai/papers/10.1016/s0021-9258(18)63474-x
The paper
Ishikawa, E., Ishikawa, S., Davis, J. W., & Sutherland, E. W. (1969). Determination of Guanosine 3',5'-Monophosphate in Tissues and of Guanyl Cyclase in Rat Intestine. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)63474-x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.