Cited by 159Iron Metabolism and DisordersTrace Elements in HealthNeurological diseases and metabolism

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Mobilization of liver iron by ferroxidase (ceruloplasmin).

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Osaki, Shigemasa, Johnson, Donald A.·1969·Journal of Biological Chemistry

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Abstract Iron was mobilized by human ferroxidase from dog liver into the perfusate under simulated physiological conditions. The rate of mobilization was estimated to be 1.8 µm per min per 4.9 µm ferroxidase. Human serum albumin with trace copper was found to be inactive in iron mobilization. The low Km and high k1 values of ferroxidase toward ferrous ion enabled us to deduce that the elimination of free iron in the perfusate by ferroxidase would generate a very steep concentration gradient between iron storage cells and the capillary system. This concentration gradient would promote a rapid iron out-flux from the cells by diffusion.

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The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum.
Osaki, S., Johnson, D. A., & Frieden, E. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96527-0 · Cited by 679
Investigations in Serum Copper. I. Nature of Serum Copper and its Relation to the Iron-Binding Protein in Human Serum.
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Kinetic Studies of Ferrous Ion Oxidation with Crystalline Human Ferroxidase (Ceruloplasmin)
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A Micromethod for the Determination of Ferroxidase (Ceruloplasmin) in Human Serums
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Copper deficiency and copper toxicity in the rat
Owen, C. A., & Hazelrig, J. (1968) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1968.215.2.334 · Cited by 76
Mobilization of iron from ferritin by chelating agents
Pape, L., Multani, J. S., Stitt, C., & Saltman, P. (1968) · Biochemistry · doi:10.1021/bi00842a015 · Cited by 64
Kinetic Studies of Ferrous Ion Oxidation with Crystalline Human Ferroxidase
Osaki, S., & Walaas, O. (1967) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99620-1 · Cited by 62
Studies on Copper Metabolism
Cartwright, G. E., Gubler, C. J., BUSH, J. A., & Wintrobe, M. M. (1956) · Blood · doi:10.1182/blood.v11.2.143.143 · Cited by 55
THE NECESSITY OF COPPER AS A SUPPLEMENT TO IRON FOR HEMOGLOBIN FORMATION IN THE PIG
Elvehjem, C. A., & Hart, E. B. (1932) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)76382-5 · Cited by 39

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Ragan, H. A., Nacht, S., Leb, G. R., Bishop, C. R., and Cartwright, G. E., Amer. J. Physiol., in press.

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Authors: Osaki, S., & Johnson, D. A.
Affiliations: Florida State University (US)
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1969-10
Volume: 244
Issue: 20
Pages: 5757-5758
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(18)63623-3
OpenAlex: W1565446694
Cited by: 159
References: 11
Citations by year: 2026: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2016: 2 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 3
FWCI: 2.30
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 18659 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords: ferroxidase, ceruloplasmin, liver iron, iron mobilization, ferrous iron oxidation, human serum albumin, copper, iron diffusion, canine liver
MeSH terms: Animals, Biological Transport, Ceruloplasmin, Dogs, Humans, Iron, Kinetics, Liver, Oxidoreductases, Perfusion, Serum Albumin, Spectrophotometry, Stimulation, Chemical, Time Factors, Transferrin, In Vitro Techniques

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Mobilization of liver iron by ferroxidase (ceruloplasmin).

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