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STIMULATION OF THE GLUCOSE OXIDATIVE PATHWAY IN HUMAN ERYTHROCYTES BY METHYLENE BLUE
Open accessAbstract
Barron and coworkers (l--3) demonstrated nearly 30 years ago that the respiration of non-nucleated erythrocytes may be greatly stimulated by the addition of methylene blue to the buffer system. Explanations for this phenomenon have been given as increased oxidation of a degradation product of glucose (2), oxidation of lactate (4), increased reversible conversion of hemoglobin to methemoglobin (5), and conversion of lactic acid to pyruvate (6). None of these explanations, however, accounted for the magnitude of the increased respiration. From the studies presented here it is proposed that methylene blue activates a cyclic glucose oxidative pathway in mammalian red cells, and that this mechanism accounts for as much as 85 per cent of the oxygen consumed by human erythrocytes in the presence of methylene blue.
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Citations
Cited by
Holmes, B., Page, A. R., & Good, R. A. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105634 · Cited by 686
The Use of Glucose-C14 for the Evaluation of the Pathways of Glucose Metabolism
Katz, J., & Wood, H. G. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64593-4 · Cited by 400
Gaetani, G., Galiano, S., Canepa, L., Ferraris, A., & Kirkman, H. (1989) · Blood · doi:10.1182/blood.v73.1.334.334 · Cited by 298
Effects of Sulfhydryl Inhibition on Red Blood Cells
Jacob, H. S., & Jandl, J. H. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99775-9 · Cited by 279
TARLOV, A. R. (1962) · Archives of Internal Medicine · doi:10.1001/archinte.1962.03620140081013 · Cited by 273
Metadata
- Authors
- Brin, M., & Yonemoto, R. H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1958-01
- Volume
- 230
- Issue
- 1
- Pages
- 307-317
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W78159807
- Cited by
- 288
- References
- 0
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: STIMULATION OF THE GLUCOSE OXIDATIVE PATHWAY IN HUMAN ERYTHROCYTES BY METHYLENE BLUE. https://app.cochat.ai/papers/10.1016/s0021-9258(18)70565-6
- The paper
- Brin, M., & Yonemoto, R. H. (1958). STIMULATION OF THE GLUCOSE OXIDATIVE PATHWAY IN HUMAN ERYTHROCYTES BY METHYLENE BLUE. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)70565-6
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
