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Cited by 273

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Primaquine Sensitivity: Glucose-6-Phosphate Dehydrogenase Deficiency: An Inborn Error of Metabolism of Medical and Biological Significance

TARLOV, ALVIN R.·1962·Archives of Internal Medicine

Abstract

The potential danger of hemolysis from use of the 8-aminoquinoline antimalarial drug, pamaquine (Plasmoquine), has been known since 1926.1Earle,2in 1948, reported that pamaquine caused hemolysis in 5%-10% of American Negroes, but rarely in Caucasians. Similar observations were made in 1952 by Hockwald3during an evaluation of the related, but less toxic drug, primaquine; it was further noted that the severity of hemolysis was determined by the amount of drug administered. In 1954, Dern4discovered that the susceptibility to hemolysis by primaquine is due to an intrinsic abnormality of the erythrocyte. Dern, Beutler, and Alving5reported that the hemolysis is self-limited in that clinical recovery occurs even if the daily dose of drug is continued. Many drugs can precipitate hemolysis.6This hypersusceptibility to hemolysis by drugs is a genetically transmitted inborn error of metabolism.7The first biochemical abnormality to characterize drug-sensitive cells,

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Metadata

Authors
TARLOV, A. R.
Venue
Archives of Internal Medicine
Published
1962-02-01
Volume
109
Issue
2
Pages
209
ISSN
0003-9926 (ISSN-L)
OpenAlex
W1984362372
Cited by
273
References
31
FWCI
33.02
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Primaquine Sensitivity: Glucose-6-Phosphate Dehydrogenase Deficiency: An Inborn Error of Metabolism of Medical and Biological Significance. https://app.cochat.ai/papers/10.1001/archinte.1962.03620140081013
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TARLOV, A. R. (1962). Primaquine Sensitivity: Glucose-6-Phosphate Dehydrogenase Deficiency: An Inborn Error of Metabolism of Medical and Biological Significance. Archives of Internal Medicine. https://doi.org/10.1001/archinte.1962.03620140081013

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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