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Studies of the Metabolic Activity of Leukocytes from Patients with a Genetic Abnormality of Phagocytic Function*
Open accessAbstract
Polymorphonuclear leukocytes from patients with chronic granulomatous disease respond to the phagocytosis of latex particles with normal increments in glucose consumption, lactate production, Krebs' cycle activity, and lipid turnover. The leukocytes of these patients fail to show normal increments in respiration, direct oxidation of glucose, and hydrogen peroxide formation during particle uptake. It appears that the stimulation of respiration with the formation of hydrogen peroxide and stimulation of the direct oxidative pathway of glucose metabolism are closely linked to degranulation and intracellular killing of bacteria by polymorphonuclear leukocytes.
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Cited by
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Klebanoff, S. J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1204697 · Cited by 2,282
Oxygen metabolism and the toxic properties of phagocytes
KLEBANOFF, S. J. (1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-3-480 · Cited by 868
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Dahlgren, C., & Karlsson, A. (1999) · Journal of Immunological Methods · doi:10.1016/s0022-1759(99)00146-5 · Cited by 810
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Nguyen, G. T., Green, E. R., & Mecsas, J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00373 · Cited by 741
Metadata
- Authors
- Holmes, B., Page, A. R., & Good, R. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1967-09-01
- Volume
- 46
- Issue
- 9
- Pages
- 1422-1432
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2113842973
- Cited by
- 686
- References
- 0
- FWCI
- 24.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Studies of the Metabolic Activity of Leukocytes from Patients with a Genetic Abnormality of Phagocytic Function*. https://app.cochat.ai/papers/10.1172/jci105634
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- Holmes, B., Page, A. R., & Good, R. A. (1967). Studies of the Metabolic Activity of Leukocytes from Patients with a Genetic Abnormality of Phagocytic Function*. Journal of Clinical Investigation. https://doi.org/10.1172/jci105634
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
