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The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.
Open accessAbstract
We have previously identified in endothelial cells a gene product designated A20, that is rapidly and profoundly induced by tumor necrosis factor alpha (Dixit, V. M., Green, S., Sarma, V., Holzman, L. B., Wolf, F. W., O'Rourke, K., Ward, P. A., Prochownik, E. V., and Marks, R. M. (1990) J. Biol. Chem. 265, 2973-2978). Isolation of the full-length cDNA followed by sequence analysis has revealed that A20 codes for a novel zinc finger protein. Structural features suggest that this putative protein, which contains multiple Cys2/Cys2 finger motifs, defines a novel class of zinc finger proteins. Southern analysis supports the existence of other members of the class.
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Cited by
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Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice
Lee, E. G., Boone, D. L., Chai, S., Libby, S. L., Chien, M., Lodolce, J. P., & Ma, A. (2000) · Science · doi:10.1126/science.289.5488.2350 · Cited by 1,409
Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB
Inohara, N., Koseki, T., del Peso, L., Hu, Y., Yee, C., Chen, S., Carrio, R., Merino, J., Liu, D., Ni, J., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.14560 · Cited by 742
Antioxidant effect of zinc in humans
Prasad, A. S., Bao, B., Beck, F. W. J., Kucuk, O., & Sarkar, F. H. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.07.007 · Cited by 520
Clinical, immunological, anti-inflammatory and antioxidant roles of zinc
Prasad, A. S. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.10.013 · Cited by 454
Metadata
- Authors
- Opipari, A. W., Boguski, M. S., & Dixit, V. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1990-09
- Volume
- 265
- Issue
- 25
- Pages
- 14705-14708
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1569068313
- Cited by
- 416
- References
- 0
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Opipari, A. W., Boguski, M. S., & Dixit, V. M. (1990). The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)77165-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
