Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289 · see citing works

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold

Walker, J. E., Saraste, M., Runswick, M. J., & Gay, N. J. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01276.x · Cited by 5,312 · see citing works

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

Zou, H., Henzel, W. J., Liu, X., Lutschg, A., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80501-2 · Cited by 3,145 · see citing works

NF-κB: Ten Years After

Baeuerle, P. A., & Baltimore, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81318-5 · Cited by 3,002 · see citing works

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

Palombella, V. J., Rando, O. J., Goldberg, A. L., & Maniatis, T. (1994) · Cell · doi:10.1016/s0092-8674(94)90482-0 · Cited by 2,097 · see citing works

Mechanisms and Functions of Cell Death

Ellis, R. E., Yuan, J., & Horvitz, H. R. (1991) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.07.110191.003311 · Cited by 2,063 · see citing works

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

Hsu, H., Xiong, J., & Goeddel, D. V. (1995) · Cell · doi:10.1016/0092-8674(95)90070-5 · Cited by 2,024 · see citing works

The Receptor for the Cytotoxic Ligand TRAIL

Pan, G., O’Rourke, K. M., Chinnaiyan, A. M., Gentz, R., Ebner, R., Ni, J., & Dixit, V. M. (1997) · Science · doi:10.1126/science.276.5309.111 · Cited by 1,755 · see citing works

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

Kuida, K., Haydar, T. F., Kuan, C.-Y., Gu, Y., Taya, C., Karasuyama, H., Su, M. S.-S., Rakic, P., & Flavell, R. A. (1998) · Cell · doi:10.1016/s0092-8674(00)81476-2 · Cited by 1,643 · see citing works

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

Yang, R.-B., Mark, M., Gray, A., Huang, A., Xie, M.-H., Zhang, M., Goddard, A., Wood, W., Gurney, A., & Godowski, P. (1998) · Nature · doi:10.1038/26239 · Cited by 1,319 · see citing works

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

Hakem, R., Hakem, A., Duncan, G. S., Henderson, J. T., Woo, M., Soengas, M. S., Elia, A., de la Pompa, J. L., Kägi, D., Khoo, W., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81477-4 · Cited by 1,284 · see citing works

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

Malinin, N. L., Boldin, M., Kovalenko, A. V., & Wallach, D. (1997) · Nature · doi:10.1038/385540a0 · Cited by 1,279 · see citing works

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

Woronicz, J. D., Gao, X., Cao, Z., Rothe, M., & Goeddel, D. V. (1997) · Science · doi:10.1126/science.278.5339.866 · Cited by 1,183 · see citing works

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

Hsu, H., Huang, J., Shu, H.-B., Baichwal, V., & Goeddel, D. V. (1996) · Immunity · doi:10.1016/s1074-7613(00)80252-6 · Cited by 1,182 · see citing works

Identification and Characterization of an IκB Kinase

Régnier, C. H., Song, H. Y., Gao, X., Goeddel, D. V., Cao, Z., & Rothe, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80344-x · Cited by 1,176 · see citing works

Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

Yoshida, H., Kong, Y., Yoshida, R., Elia, A., Hakem, A., Hakem, R., Penninger, J. M., & Mak, T. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81733-x · Cited by 1,138 · see citing works

Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

Srinivasula, S. M., Ahmad, M., Fernandes‐Alnemri, T., & Alnemri, E. S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80095-7 · Cited by 1,119 · see citing works

Caspases: the proteases of the apoptotic pathway

Núñez, G., Benedict, M., Hu, Y., & Inohara, N. (1998) · Oncogene · doi:10.1038/sj.onc.1202581 · Cited by 1,046 · see citing works

Molecular Genetics of Plant Disease Resistance

Staskawicz, B. J., Ausubel, F. M., Baker, B., Ellis, J. G., & Jones, J. D. G. (1995) · Science · doi:10.1126/science.7732374 · Cited by 911 · see citing works

Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development

Cecconi, F., Álvarez-Bolado, G., Meyer, B. I., Roth, K. A., & Gruß, P. (1998) · Cell · doi:10.1016/s0092-8674(00)81732-8 · Cited by 894 · see citing works

A structural basis of the interactions between leucine-rich repeats and protein ligands

Kobe, B., & Deisenhofer, J. (1995) · Nature · doi:10.1038/374183a0 · Cited by 729 · see citing works

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

Chinnaiyan, A. M., O’Rourke, K. M., Lane, B. R., & Dixit, V. M. (1997) · Science · doi:10.1126/science.275.5303.1122 · Cited by 626 · see citing works

Tumor necrosis factor receptor-associated factors (TRAFs)—a family of adapter proteins that regulates life and deathPreprint

Arch, R. H., Gedrich, R. W., & Thompson, C. B. (1998) · Genes & Development · doi:10.1101/gad.12.18.2821 · Cited by 611 · see citing works

The NB-ARC domain: a novel signalling motif shared by plant resistance gene products and regulators of cell death in animals

van der Biezen, E. A., & Jones, J. D. G. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70145-9 · Cited by 577 · see citing works

Novel Disease Resistance Specificities Result from Sequence Exchange between Tandemly Repeated Genes at the Cf-4/9 Locus of Tomato

Parniske, M., Hammond-Kosack, K. E., Golstein, C., Thomas, C. M., Jones, D. A., Harrison, K., Wulff, B. B. H., & Jones, J. D. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80470-5 · Cited by 565 · see citing works

RAIDD is a new 'death' adaptor molecule

Duan, H., & Dixit, V. M. (1997) · Nature · doi:10.1038/385086a0 · Cited by 550 · see citing works

The CARD domain: a new apoptotic signalling motif

Hofmann, K. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01043-8 · Cited by 537 · see citing works

Bcl-X L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

Hu, Y., Benedict, M., Wu, D., Inohara, N., & Núñez, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4386 · Cited by 529 · see citing works

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

Pan, G., O’Rourke, K. M., & Dixit, V. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5841 · Cited by 523 · see citing works

The TRAF Family of Signal Transducers Mediates NF-κB Activation by the TRANCE Receptor

Wong, B. R., Josien, R., Lee, S. Y., Vologodskaia, M., Steinman, R. M., & Choi, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28355 · Cited by 458 · see citing works

RIP2 Is a Novel NF-κB-activating and Cell Death-inducing Kinase

McCarthy, J. V., Ni, J., & Dixit, V. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.27.16968 · Cited by 438 · see citing works

The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.

Opipari, A. W., Boguski, M. S., & Dixit, V. M. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77165-2 · Cited by 419 · see citing works

Proteins with leucine-rich repeats

Kobe, B., & Deisenhofer, J. (1995) · Current Opinion in Structural Biology · doi:10.1016/0959-440x(95)80105-7 · Cited by 392 · see citing works

ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases

Koseki, T., Inohara, N., Chen, S., & Núñez, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5156 · Cited by 347 · see citing works

Interaction and Regulation of Subcellular Localization of CED-4 by CED-9

Wu, D., Wallen, H. D., & Núñez, G. (1997) · Science · doi:10.1126/science.275.5303.1126 · Cited by 341 · see citing works

CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor

Inohara, N., Koseki, T., Chen, S., Wu, X., & Núñez, G. (1998) · The EMBO Journal · doi:10.1093/emboj/17.9.2526 · Cited by 323 · see citing works

Identification of CARDIAK, a RIP-like kinase that associates with caspase-1

Thome, M., Hofmann, K., Burns, K., Martinon, F., Bodmer, J.-L., Mattmann, C., & Tschopp, J. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00352-1 · Cited by 319 · see citing works

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis

Inohara, N., Koseki, T., Hu, Y., Chen, S., & Núñez, G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10717 · Cited by 315 · see citing works

Interaction between the C. elegans cell-death regulators CED-9 and CED-4

Spector, M. S., Desnoyers, S., Hoeppner, D. J., & Hengartner, M. O. (1997) · Nature · doi:10.1038/385653a0 · Cited by 304 · see citing works

Solution Structure of the RAIDD CARD and Model for CARD/CARD Interaction in Caspase-2 and Caspase-9 Recruitment

Chou, J. J., Matsuo, H., Duan, H., & Wagner, G. (1998) · Cell · doi:10.1016/s0092-8674(00)81417-8 · Cited by 300 · see citing works

Essential Role of CED-4 Oligomerization in CED-3 Activation and Apoptosis

Yang, X., Chang, H. Y., & Baltimore, D. (1998) · Science · doi:10.1126/science.281.5381.1355 · Cited by 269 · see citing works

TRAMP, a Novel Apoptosis-Mediating Receptor with Sequence Homology to Tumor Necrosis Factor Receptor 1 and Fas(Apo-1/CD95)

Bodmer, J.-L., Burns, K., Schneider, P., Hofmann, K., Steiner, V., Thome, M., Bornand, T., Hahne, M., Schröter, M., Becker, K., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80244-7 · Cited by 262 · see citing works

WD-40 Repeat Region Regulates Apaf-1 Self-association and Procaspase-9 Activation

Hu, Y., Ding, L., Spencer, D. M., & Núñez, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33489 · Cited by 256 · see citing works

RICK, a Novel Protein Kinase Containing a Caspase Recruitment Domain, Interacts with CLARP and Regulates CD95-mediated Apoptosis

Inohara, N., del Peso, L., Koseki, T., Chen, S., & Núñez, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.20.12296 · Cited by 245 · see citing works

Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B.

Miyamoto, S., Maki, M., Schmitt, M. J., Hatanaka, M., & Verma, I. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12740 · Cited by 206 · see citing works

IκB kinase: Beginning, not the end

Verma, I. M., & Stevenson, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.11758 · Cited by 199 · see citing works

Advances in apoptosis research

Peter, M. E., Heufelder, A. E., & Hengartner, M. O. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.12736 · Cited by 199 · see citing works

Role of CED-4 in the activation of CED-3

Chinnaiyan, A. M., Chaudhary, D., O’Rourke, K. M., Koonin, E. V., & Dixit, V. M. (1997) · Nature · doi:10.1038/41913 · Cited by 194 · see citing works

Diva, a Bcl-2 Homologue that Binds Directly to Apaf-1 and Induces BH3-independent Cell Death

Inohara, N., Gourley, T. S., Carrió, R., Muniz, M. E. B., Merino, J., Garcia, I., Koseki, T., Hu, Y., Chen, S., & Núñez, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32479 · Cited by 174 · see citing works

Interaction and Regulation of the Caenorhabditis elegans Death Protease CED-3 by CED-4 and CED-9

Wu, D., Wallen, H. D., Inohara, N., & Núñez, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21449 · Cited by 130 · see citing works

Mtd, a Novel Bcl-2 Family Member Activates Apoptosis in the Absence of Heterodimerization with Bcl-2 and Bcl-XL

Inohara, N., Ekhterae, D., Garcia, I., Carrió, R., Merino, J., Merry, A. C., Chen, S., & Núñez, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8705 · Cited by 129 · see citing works

Caenorhabditis elegans EGL-1 Disrupts the Interaction of CED-9 with CED-4 and Promotes CED-3 Activation

del Peso, L., González, V. M., & Núñez, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33495 · Cited by 105 · see citing works

Importance of acidic, proline/serine/threonine-rich, and GTPbinding regions in the major histocompatibility complex class II transactivator: Generation of transdominant-negative mutants

Chin, K.-C., Li, G. G.-X., & Ting, J. P. ‐. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2501 · Cited by 101 · see citing works

Negative regulation of immunoglobulin kappa light-chain gene transcription by a short sequence homologous to the murine B1 repetitive element.

Saksela, K., & Baltimore, D. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.6.3698 · Cited by 85 · see citing works

The Death Inhibitory Molecules CED-9 and CED-4L Use a Common Mechanism to Inhibit the CED-3 Death Protease

Chaudhary, D., O’Rourke, K. M., Chinnaiyan, A. M., & Dixit, V. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17708 · Cited by 39 · see citing works

Innate immune recognition

Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394 · see citing works

Toll-Like Receptors

Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143 · see citing works

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591 · see citing works

Toll-like receptors and innate immunity

Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308 · see citing works

Regulation and Function of NF-κB Transcription Factors in the Immune System

Vallabhapurapu, S., & Karin, M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132641 · Cited by 2,578 · see citing works

The Inflammasomes: Guardians of the Body

Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436 · see citing works

Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection

Girardin, S. E., Boneca, I. G., Viala, J., Chamaillard, M., Labigne-Roussel, A., Thomas, G. D., Philpott, D. J., & Sansonetti, P. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200651200 · Cited by 2,397 · see citing works

Mechanisms of Caspase Activation and Inhibition during Apoptosis

Shi, Y. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00482-3 · Cited by 1,824 · see citing works

The leucine-rich repeat as a protein recognition motif

Kobe, B. (2001) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(01)00266-4 · Cited by 1,669 · see citing works

Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

Girardin, S. E., Boneca, I. G., Carneiro, L. A. M., Antignac, A., Jéhanno, M., Viala, J., Tedin, K., Taha, M., Labigne-Roussel, A., Zäthringer, U., et al. (2003) · Science · doi:10.1126/science.1084677 · Cited by 1,574 · see citing works

Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κB

Ogura, Y., Inohara, N., Benito, A., Chen, F. F., Yamaoka, S., & Núñez, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008072200 · Cited by 1,357 · see citing works

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

Chamaillard, M., Hashimoto, M., Horie, Y., Masumoto, J., Qiu, S., Saab, L., Ogura, Y., Kawasaki, A., Fukase, K., Kusumoto, S., et al. (2003) · Nature Immunology · doi:10.1038/ni945 · Cited by 1,323 · see citing works

Mechanisms of Apoptosis

Reed, J. C. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64779-7 · Cited by 1,286 · see citing works

Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

Viala, J., Chaput, C., Boneca, I. G., Cardona, A., Girardin, S. E., Moran, A. P., Athman, R., Mémet, S., Huerre, M., Coyle, A. J., et al. (2004) · Nature Immunology · doi:10.1038/ni1131 · Cited by 1,221 · see citing works

Intracellular pattern recognition receptors in the host response

Meylan, E., Tschopp, J., & Karin, M. (2006) · Nature · doi:10.1038/nature04946 · Cited by 1,196 · see citing works

Bacterial lipopolysaccharides and innate immunity

Alexander, C., & Rietschel, E. T. (2001) · Journal of Endotoxin Research · doi:10.1179/096805101101532675 · Cited by 1,173 · see citing works

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

Clarke, T. B., Davis, K. M., Lysenko, E. S., Zhou, A. Y., Yu, Y., & Weiser, J. N. (2010) · Nature Medicine · doi:10.1038/nm.2087 · Cited by 1,154 · see citing works

Regulation of inflammasome activation

Man, S. M., & Kanneganti, T. (2015) · Immunological Reviews · doi:10.1111/imr.12296 · Cited by 1,071 · see citing works

NODs: intracellular proteins involved in inflammation and apoptosis

Inohara, N., & Núñez, G. (2003) · Nature reviews. Immunology · doi:10.1038/nri1086 · Cited by 1,063 · see citing works

Intracellular NOD-like Receptors in Host Defense and Disease

Kanneganti, T., Lamkanfi, M., & Núñez, G. (2007) · Immunity · doi:10.1016/j.immuni.2007.10.002 · Cited by 1,056 · see citing works

NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease

Inohara, N., Chamaillard, M., McDonald, C., & Núñez, G. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133347 · Cited by 993 · see citing works

CARD15/NOD2 Mutational Analysis and Genotype-Phenotype Correlation in 612 Patients with Inflammatory Bowel Disease

Lesage, S., Zouali, H., Cézard, J., Colombel, J., Bélaïche, J., Almer, S. H., Tysk, C., O'Morain, C. A., Gassull, M. A., Binder, V., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/339432 · Cited by 992 · see citing works

NF-κB signaling pathways in mammalian and insect innate immunityPreprint

Silverman, N. S., & Maniatis, T. (2001) · Genes & Development · doi:10.1101/gad.909001 · Cited by 904 · see citing works

Function of Nod‐like receptors in microbial recognition and host defense

Franchi, L., Warner, N. E., Viani, K. L., & Núñez, G. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00734.x · Cited by 900 · see citing works

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

Kobayashi, K. S., Inohara, N., Hernandez, L. D., Galán, J. E., Núñez, G., Janeway, C. A., Medzhitov, R. M., & Flavell, R. A. (2002) · Nature · doi:10.1038/416194a · Cited by 888 · see citing works

Signalling pathways and molecular interactions of NOD1 and NOD2

Strober, W., Murray, P. J., Kitani, A., & Watanabe, T. (2005) · Nature reviews. Immunology · doi:10.1038/nri1747 · Cited by 856 · see citing works

NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

Caruso, R., Warner, N., Inohara, N., & Núñez, G. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.010 · Cited by 830 · see citing works

NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

Chen, G., Shaw, M. H., Kim, Y., & Núñez, G. (2008) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092239 · Cited by 770 · see citing works

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

Saito, T., Hirai, R., Loo, Y., Owen, D. M., Johnson, C., Sinha, S. C., Akira, S., Fujita, T., & Gale, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606699104 · Cited by 743 · see citing works

Plant NBS-LRR proteins in pathogen sensing and host defense

DeYoung, B. J., & Innes, R. W. (2006) · Nature Immunology · doi:10.1038/ni1410 · Cited by 738 · see citing works

NALPs: a novel protein family involved in inflammation

Tschopp, J., Martinon, F., & Burns, K. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1019 · Cited by 719 · see citing works

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

Borner, C. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(02)00252-3 · Cited by 700 · see citing works

Peptidoglycan Molecular Requirements Allowing Detection by Nod1 and Nod2

Girardin, S. E., Travassos, L. H., Hervé, M., Blanot, D., Boneca, I. G., Philpott, D. J., Sansonetti, P. J., & Mengin‐Lecreulx, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307198200 · Cited by 684 · see citing works

NOD proteins: regulators of inflammation in health and disease

Philpott, D. J., Sorbara, M. T., Robertson, S. J., Croitoru, K., & Girardin, S. E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3565 · Cited by 668 · see citing works

CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

Hisamatsu, T., Suzuki, M., Reinecker, H., Nadeau, W. J., McCormick, B. A., & Podolsky, D. K. (2003) · Gastroenterology · doi:10.1053/gast.2003.50153 · Cited by 632 · see citing works

CARD4/Nod1 mediates NF‐κB and JNK activation by invasive Shigella flexneri

Girardin, S. E., Tournebize, R., Mavris, M., Page, A., Li, X., Stark, G. R., Bertin, J., DiStefano, P. S., Yaniv, M., Sansonetti, P. J., et al. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve155 · Cited by 608 · see citing works

Pathogen recognition in the innate immune response

Kumar, H., Kawai, T., & Akira, S. (2009) · Biochemical Journal · doi:10.1042/bj20090272 · Cited by 586 · see citing works

Epithelial crosstalk at the microbiota–mucosal interface

Wells, J. M., Rossi, O., Meijerink, M., & van Baarlen, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000092107 · Cited by 574 · see citing works

The PYRIN-CARD Protein ASC Is an Activating Adaptor for Caspase-1

Srinivasula, S. M., Poyet, J.-L., Razmara, M., Datta, P., Zhang, Z., & Alnemri, E. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200179200 · Cited by 573 · see citing works

The Genetics of Inflammatory Bowel Disease

Cho, J. H., & Weaver, C. T. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.032 · Cited by 550 · see citing works

An Induced Proximity Model for NF-κB Activation in the Nod1/RICK and RIP Signaling Pathways

Inohara, N., Koseki, T., Lin, J., del Peso, L., Lucas, P. C., Chen, F. F., Ogura, Y., & Núñez, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003415200 · Cited by 538 · see citing works

Human Nod1 Confers Responsiveness to Bacterial Lipopolysaccharides

Inohara, N., Ogura, Y., Chen, F. F., Muto, A., & Núñez, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009728200 · Cited by 532 · see citing works

The Death Domain Superfamily in Intracellular Signaling of Apoptosis and Inflammation

Park, H. H., Lo, Y.-C., Lin, S., Wang, L., Yang, J. K., & Wu, H. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141656 · Cited by 523 · see citing works

A critical role of RICK/RIP2 polyubiquitination in Nod‐induced NF‐κB activation

Hasegawa, M., Fujimoto, Y., Lucas, P. C., Nakano, H., Fukase, K., Núñez, G., & Inohara, N. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601962 · Cited by 520 · see citing works

The Bare Lymphocyte Syndrome and the Regulation of MHC Expression

Reith, W., & Mach, B. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.331 · Cited by 517 · see citing works

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

Sagulenko, V., Thygesen, S. J., Sester, D. P., Idris, A., Cridland, J. A., Vajjhala, P. R., Roberts, T. L., Schroder, K., Vince, J. E., Hill, J. M., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.37 · Cited by 511 · see citing works

Ubiquitin signaling in immune responses

Hu, H., & Sun, S. (2016) · Cell Research · doi:10.1038/cr.2016.40 · Cited by 481 · see citing works

Recognition ofStaphylococcus aureusby the Innate Immune System

Fournier, B., & Philpott, D. J. (2005) · Clinical Microbiology Reviews · doi:10.1128/cmr.18.3.521-540.2005 · Cited by 475 · see citing works

NOD-like receptors and inflammasomes: A review of their canonical and non-canonical signaling pathways

Platnich, J. M., & Muruve, D. A. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.02.008 · Cited by 475 · see citing works

Peptidoglycan recognition by the innate immune system

Wolf, A. J., & Underhill, D. M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.136 · Cited by 469 · see citing works

STAND, a Class of P-Loop NTPases Including Animal and Plant Regulators of Programmed Cell Death: Multiple, Complex Domain Architectures, Unusual Phyletic Patterns, and Evolution by Horizontal Gene Transfer

Leipe, D. D., Koonin, E. V., & Aravind, L. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.08.023 · Cited by 465 · see citing works

Identification of Ipaf, a Human Caspase-1-activating Protein Related to Apaf-1

Poyet, J., Srinivasula, S. M., Tnani, M., Razmara, M., Fernandes‐Alnemri, T., & Alnemri, E. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100250200 · Cited by 456 · see citing works

NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways

Cui, J., Zhu, L., Xia, X., Wang, H. Y., Legras, X. D., Hong, J. K., Ji, J., Shen, P., Zheng, S. S., Chen, Z. J., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.040 · Cited by 449 · see citing works

Mechanisms of programmed cell death in the developing brain

Kuan, C.-Y., Roth, K. A., Flavell, R. A., & RAKIC, P. T. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01581-2 · Cited by 444 · see citing works

Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation

Gutiérrez, O., Pipaón, C., Inohara, N., Fontalba, A., Ogura, Y., Prósper, F., Núñez, G., & Fernández-Luna, J. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206473200 · Cited by 441 · see citing works

TNF-α and IFN-γ regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells

Rosenstiel, P. C., Fantini, M. C., Bräutigam, K., Waetzig, G., Kuehbacher, T., Seegert, D., & Schreiber, S. (2003) · Gastroenterology · doi:10.1053/gast.2003.50157 · Cited by 423 · see citing works

Bcl10 and MALT1, Independent Targets of Chromosomal Translocation in MALT Lymphoma, Cooperate in a Novel NF-κB Signaling Pathway

Lucas, P. C., Yonezumi, M., Inohara, N., McAllister‐Lucas, L. M., Abazeed, M. E., Chen, F. F., Yamaoka, S., Seto, M., & Núñez, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009984200 · Cited by 417 · see citing works

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system

Boneca, I. G., Dussurget, O., Cabanes, D., Nahori, M., Sousa, S., Lecuit, M., Psylinakis, E., Bouriotis, V., Hugot, J., Giovannini, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609672104 · Cited by 378 · see citing works

Mucosal immunity to pathogenic intestinal bacteria

Pérez-López, A., Behnsen, J., Nuccio, S., & Raffatellu, M. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2015.17 · Cited by 374 · see citing works

PYPAF7, a Novel PYRIN-containing Apaf1-like Protein That Regulates Activation of NF-κB and Caspase-1-dependent Cytokine Processing

Wang, L., Manji, G. A., Grenier, J. M., Al-Garawi, A. A., Merriam, S., Lora, J. M., Geddes, B. J., Briskin, M., DiStefano, P. S., & Bertin, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203915200 · Cited by 371 · see citing works

Approaching the Asymptote: 20 Years Later

Medzhitov, R. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.004 · Cited by 367 · see citing works

Expanded functions for a family of plant intracellular immune receptors beyond specific recognition of pathogen effectors

Bonardi, V., Tang, S., Stallmann, A., Roberts, M., Cherkis, K., & Dangl, J. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113726108 · Cited by 365 · see citing works

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

Tanabe, T., Chamaillard, M., Ogura, Y., Li, Z., Qiu, S., Masumoto, J., Ghosh, P., Moran, A. P., Predergast, M. M., Tromp, G. C., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600175 · Cited by 362 · see citing works

A comprehensive map of the toll‐like receptor signaling network

Oda, K., & Kitano, H. (2006) · Molecular Systems Biology · doi:10.1038/msb4100057 · Cited by 354 · see citing works

BNIP3 Heterodimerizes with Bcl-2/Bcl-XL and Induces Cell Death Independent of a Bcl-2 Homology 3 (BH3) Domain at Both Mitochondrial and Nonmitochondrial Sites

Ray, R., Chen, G., Velde, C. V., Cizeau, J., Park, J. H., Reed, J. C., Gietz, R. D., & Greenberg, A. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1439 · Cited by 349 · see citing works

CATERPILLER: A Novel Gene Family Important in Immunity, Cell Death, and Diseases

Ting, J. P.-Y., & Davis, B. K. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115616 · Cited by 349 · see citing works

Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation

Chamaillard, M., Girardin, S. E., Viala, J., & Philpott, D. J. (2003) · Cellular Microbiology · doi:10.1046/j.1462-5822.2003.00304.x · Cited by 344 · see citing works

Common and Contrasting Themes of Plant and Animal Diseases

Staskawicz, B. J., Mudgett, M. B., Dangl, J. L., & Galán, J. E. (2001) · Science · doi:10.1126/science.1062013 · Cited by 343 · see citing works

CARD11 and CARD14 Are Novel Caspase Recruitment Domain (CARD)/Membrane-associated Guanylate Kinase (MAGUK) Family Members that Interact with BCL10 and Activate NF-κB

Bertin, J., Wang, L., Guo, Y., Jacobson, M. D., Poyet, J., Srinivasula, S. M., Merriam, S., DiStefano, P. S., & Alnemri, E. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010512200 · Cited by 343 · see citing works

Constitutive gain‐of‐function mutants in a nucleotide binding site–leucine rich repeat protein encoded at the Rx locus of potato

Bendahmane, A., Farnham, G., Moffett, P., & Baulcombe, D. C. (2002) · The Plant Journal · doi:10.1046/j.1365-313x.2002.01413.x · Cited by 338 · see citing works

Mechanisms of bacterial lipopolysaccharide-induced endothelial apoptosis

Bannerman, D. D., & Goldblum, S. E. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00338.2002 · Cited by 332 · see citing works

Apoptosis-regulating proteins as targets for drug discovery

Reed, J. C. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02026-3 · Cited by 328 · see citing works

Nucleotide-binding Oligomerization Domain Proteins Are Innate Immune Receptors for Internalized Streptococcus pneumoniae

Opitz, B., Püschel, A., Schmeck, B., Hocke, A. C., Rosseau, S., Hammerschmidt, S., Schumann, R. R., Suttorp, N., & Hippenstiel, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403861200 · Cited by 327 · see citing works

Functions of NOD-Like Receptors in Human Diseases

Zhong, Y., Kinio, A. E., & Saleh, M. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00333 · Cited by 317 · see citing works

Cutting Edge: CATERPILLER: A Large Family of Mammalian Genes Containing CARD, Pyrin, Nucleotide-Binding, and Leucine-Rich Repeat Domains

Harton, J. A., Linhoff, M. W., Zhang, J., & Ting, J. P. ‐. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.8.4088 · Cited by 316 · see citing works

Apoptosomes: engines for caspase activation

Adams, J. M., & Cory, S. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00381-2 · Cited by 305 · see citing works

Patterns of Positive Selection in the Complete NBS-LRR Gene Family of Arabidopsis thalianaPreprint

Mondragón‐Palomino, M., Meyers, B. C., Michelmore, R. W., & Gaut, B. S. (2002) · Genome Research · doi:10.1101/gr.159402 · Cited by 302 · see citing works

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF‐κB and caspase‐1

Grenier, J. M., Wang, L., Manji, G. A., Huang, W.-J., Al-Garawi, A. A., Kelly, R., Carlson, A., Merriam, S., Lora, J. M., Briskin, M., et al. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03416-6 · Cited by 296 · see citing works

The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis

Lavelle, E. C., Murphy, C. H., O'Neill, L. A. J., & Creagh, E. M. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.124 · Cited by 291 · see citing works

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor–κB activation in muramyl dipeptide recognition

Barnich, N., Aguirre, J. E., Reinecker, H., Xavier, R. J., & Podolsky, D. K. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200502153 · Cited by 289 · see citing works

XIAP mediates NOD signaling via interaction with RIP2

Krieg, A. H., Correa, R. G., Garrison, J. B., Negrate, G. L., Welsh, K., Huang, Z., Knoefel, W. T., & Reed, J. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907131106 · Cited by 287 · see citing works

Untitled work

(2016) · PubMed · Cited by 287 · see citing works

The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands

Kim, Y., Park, J., Shaw, M. H., Franchi, L., Inohara, N., & Núñez, G. (2008) · Immunity · doi:10.1016/j.immuni.2007.12.012 · Cited by 280 · see citing works

PYPAF1, a PYRIN-containing Apaf1-like Protein That Assembles with ASC and Regulates Activation of NF-κB

Manji, G. A., Wang, L., Geddes, B. J., Brown, M., Merriam, S., Al-Garawi, A. A., Mak, S., Lora, J. M., Briskin, M., Jurman, M. E., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112208200 · Cited by 275 · see citing works

NOD-Like Receptors: Master Regulators of Inflammation and Cancer

Saxena, M., & Yeretssian, G. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00327 · Cited by 272 · see citing works

Regulation of IL-8 and IL-1 expression in Crohn's disease associated NOD2/CARD15 mutations

Li, J. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh182 · Cited by 272 · see citing works

The role of Toll-like receptors and Nod proteins in bacterial infection

Philpott, D. J., & Girardin, S. E. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.06.012 · Cited by 270 · see citing works

NOD1 and NOD2 Signaling in Infection and Inflammation

Moreira, L. O., & Zamboni, D. S. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00328 · Cited by 267 · see citing works

NOD1 variation, immunoglobulin E and asthma

Hysi, P. G., Kabesch, M., Moffatt, M. F., Schedel, M., Carr, D., Zhang, Y., Boardman, B., von Mutius, E., Weiland, S. K., Leupold, W., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi087 · Cited by 266 · see citing works

The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis

Chen, G. Y., Shaw, M. H., Redondo, G., & Núñez, G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2061 · Cited by 261 · see citing works

The role of inflammasomes in human diseases and their potential as therapeutic targets

Yao, J., Sterling, K., Wang, Z., Zhang, Y., & Song, W. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01687-y · Cited by 256 · see citing works

Mechanisms governing inflammasome activation, assembly and pyroptosis induction

Kesavardhana, S., & Kanneganti, T. (2017) · International Immunology · doi:10.1093/intimm/dxx018 · Cited by 254 · see citing works

Intestinal antimicrobial peptides during homeostasis, infection, and disease

Muniz, L. R., Knosp, C. A., & Yeretssian, G. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00310 · Cited by 252 · see citing works

The Immune Receptor NOD1 and Kinase RIP2 Interact with Bacterial Peptidoglycan on Early Endosomes to Promote Autophagy and Inflammatory Signaling

Irving, A. T., Mimuro, H., Kufer, T. A., Lo, C. Y.-W., Wheeler, R., Turner, L., Thomas, B. J., Malosse, C., Gantier, M. P., Casillas, L., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.04.001 · Cited by 249 · see citing works

Nod1 Is an Essential Signal Transducer in Intestinal Epithelial Cells Infected with Bacteria That Avoid Recognition by Toll-Like Receptors

Kim, J. G., Lee, S. J., & Kagnoff, M. F. (2004) · Infection and Immunity · doi:10.1128/iai.72.3.1487-1495.2004 · Cited by 249 · see citing works

TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers.

Conway, K. E., McConnell, B. B., Bowring, C. E., Donald, C. D., Warren, S. T., & Vertino, P. M. (2000) · PubMed · Cited by 249 · see citing works

RIP kinases as modulators of inflammation and immunity

He, S., & Wang, X. (2018) · Nature Immunology · doi:10.1038/s41590-018-0188-x · Cited by 246 · see citing works

Expanding role of ubiquitination in NF-κB signaling

Liu, S., & Chen, Z. J. (2010) · Cell Research · doi:10.1038/cr.2010.170 · Cited by 243 · see citing works

A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish

Laing, K. J., Purcell, M. K., Winton, J. R., & Hansen, J. D. (2008) · BMC Evolutionary Biology · doi:10.1186/1471-2148-8-42 · Cited by 238 · see citing works

Nods: a family of cytosolic proteins that regulate the host response to pathogens

Inohara, N. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00289-8 · Cited by 238 · see citing works

Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κB

Ogura, Y., Inohara, N., Benito, A., Chen, F. F., Yamaoka, S., & Núñez, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008072200 · Cited by 1,357 · see citing works

An Induced Proximity Model for NF-κB Activation in the Nod1/RICK and RIP Signaling Pathways

Inohara, N., Koseki, T., Lin, J., del Peso, L., Lucas, P. C., Chen, F. F., Ogura, Y., & Núñez, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003415200 · Cited by 538 · see citing works

CARDINAL, a Novel Caspase Recruitment Domain Protein, Is an Inhibitor of Multiple NF-κB Activation Pathways

Bouchier‐Hayes, L., Conroy, H., Egan, H., Adrain, C., Creagh, E. M., MacFarlane, M., & Martin, S. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107373200 · Cited by 112 · see citing works

CARD6 Is a Modulator of NF-κB Activation by Nod1- and Cardiak-mediated Pathways

Stehlik, C., Hayashi, H., Pio, F., Godzik, A., & Reed, J. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300009200 · Cited by 69 · see citing works

Human CARD4 Protein Is a Novel CED-4/Apaf-1 Cell Death Family Member That Activates NF-κB

Bertin, J., Nir, W.-J., Fischer, C., Tayber, O., Errada, P. R., Grant, J. R., Keilty, J., Gosselin, M., Robison, K. E., Wong, G. H., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.12955 · Cited by 366 · see citing works