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Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin.
Open accessAbstract
Human mammary cells present on the cell surface a polymorphic epithelial mucin (PEM) which is developmentally regulated and aberrantly expressed in tumors. PEM carries tumor-associated epitopes recognized by the monoclonal antibodies HMFG-1, HMFG-2, and SM-3. Previously isolated partial cDNA clones revealed that the core protein contained a large domain consisting of variable numbers of 20-amino acid repeat units. We now report the full sequence for PEM, as deduced from cDNA sequences. The encoded protein consists of three distinct regions: the amino terminus consisting of a putative signal peptide and degenerate repeats; the major portion of the protein which is the tandem repeat region; the carboxyl terminus consisting of degenerate tandem repeats and a unique sequence containing a transmembrane sequence and a cytoplasmic tail. Potential O-glycosylation sites (serines or threonines) make up more than one-fourth of the amino acids. Length variations in the tandem repeat result in PEM being an expressed variable number tandem repeat locus. Tandem repeats appear to be a general characteristic of mucin core proteins.
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Citations
Cited by
The gastrointestinal mucus system in health and disease
Johansson, M. E. V., Sjövall, H., & Hansson, G. C. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.35 · Cited by 1,438
Endometrial receptivity markers, the journey to successful embryo implantation.
Achache, H., & Revel, A. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml004 · Cited by 952
Mucin-bacterial interactions in the human oral cavity and digestive tract
Derrien, M., van Passel, M. W. J., van de Bovenkamp, J. H. B., Schipper, R., de Vos, W., & Dekker, J. (2010) · Gut Microbes · doi:10.4161/gmic.1.4.12778 · Cited by 556
Mucins and mucin binding proteins in colorectal cancer
Byrd, J. C., & Bresalier, R. S. (2004) · Cancer and Metastasis Reviews · doi:10.1023/a:1025815113599 · Cited by 490
Wesseling, J., van der Valk, S. W., Vos, H. L., Sonnenberg, A., & Hilkens, J. (1995) · The Journal of cell biology · doi:10.1083/jcb.129.1.255 · Cited by 486
Metadata
- Authors
- Gendler, S. J., Lancaster, C. A., Taylor-Papadimitriou, J., Duhig, T., Peat, N., Burchell, J., Pemberton, L., Lalani, E. N., & Wilson, D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1990-09
- Volume
- 265
- Issue
- 25
- Pages
- 15286-15293
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1595402802
- Cited by
- 976
- References
- 0
- FWCI
- 13.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gendler, S. J., Lancaster, C. A., Taylor-Papadimitriou, J., Duhig, T., Peat, N., Burchell, J., Pemberton, L., Lalani, E. N., & Wilson, D. (1990). Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)77254-2
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