The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components.
Open accessAbstract
Episialin (MUC1) is a transmembrane molecule with a large mucin-like extracellular domain protruding high above the cell surface. The molecule is located at the apical side of most glandular epithelial cells, whereas in carcinoma cells it is often present at the entire surface and it is frequently expressed in abnormally large quantities. We have previously shown that overexpression of episialin reduces cell-cell interactions. Here we show that the integrin-mediated adhesion to extracellular matrix of transfectants of a melanoma cell line (A375), a transformed epithelial cell line (MDCK-ras-e) and a human breast epithelial cell line (HBL-100) is reduced by high levels of episialin. This reduction can be reversed by inducing high avidity of the beta 1 integrins by mAb TS2/16 (at least for beta 1-mediated adhesion). The adhesion can also be restored by redistribution of episialin on the cell surface by monoclonal antibodies into patches or caps. Similarly, capping of episialin on ZR-75-1 breast carcinoma cells, growing in suspension, caused adherence and spreading of these cells. We propose that there is a delicate balance between adhesion and anti-adhesion forces in episialin expressing cells, which can be shifted towards adhesion by strengthening the integrin-mediated adhesion, or towards anti-adhesion by increasing the level of expression of episialin.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,221
Calcium's Role in Mechanotransduction during Muscle Development
Benavides Damm, T., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,502
Antibodies, a laboratory manual
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,366
Integrins: Versatility, modulation, and signaling in cell adhesion
Hynes, R. O. (1992) · Cell · doi:10.1016/0092-8674(92)90115-s · Cited by 9,859
Vleminckx, K., Vakaet, L., Mareel, M., Fiers, W., & Van Roy, F. (1991) · Cell · doi:10.1016/0092-8674(91)90143-m · Cited by 1,656
Werb, Z., Tremble, P. M., Behrendtsen, O., Crowley, E., & Damsky, C. H. (1989) · The Journal of cell biology · doi:10.1083/jcb.109.2.877 · Cited by 1,059
Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin.
Gendler, S. J., Lancaster, C. A., Taylor-Papadimitriou, J., Duhig, T., Peat, N., Burchell, J., Pemberton, L., Lalani, E. N., & Wilson, D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77254-2 · Cited by 976
Behrens, J., Mareel, M. M., Van Roy, F. M., & Birchmeier, W. (1989) · The Journal of cell biology · doi:10.1083/jcb.108.6.2435 · Cited by 946
Why are proteins O-glycosylated?
Jentoft, N. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90014-3 · Cited by 705
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Shedding of Kidney Injury Molecule-1, a Putative Adhesion Protein Involved in Renal Regeneration
Bailly, V., Zhang, Z., Meier, W., Cate, R., Sanicola, M., & Bonventre, J. V. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200562200 · Cited by 355
Mucin gene structure and expression: protection vs. adhesion
Van Klinken, B. J., Dekker, J., Buller, H. A., & Einerhand, A. W. (1995) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1995.269.5.g613 · Cited by 319
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Bousquet, J., Jacquot, W., Vignola, A. M., Bachert, C., & Van Cauwenberge, P. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.09.047 · Cited by 180
MUC1 (CD227): a multi-tasked molecule
Apostolopoulos, V., Stojanovska, L., & Gargosky, S. E. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2014-z · Cited by 138
Metadata
- Authors
- Wesseling, J., van der Valk, S. W., Vos, H. L., Sonnenberg, A., & Hilkens, J.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1995-04-01
- Volume
- 129
- Issue
- 1
- Pages
- 255-265
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2155058151
- Cited by
- 486
- References
- 29
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components. https://app.cochat.ai/papers/10.1083/jcb.129.1.255
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- Wesseling, J., van der Valk, S. W., Vos, H. L., Sonnenberg, A., & Hilkens, J. (1995). Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components. The Journal of cell biology. https://doi.org/10.1083/jcb.129.1.255
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
