The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Adenyl Cyclase in Fat Cells
Open accessAbstract
Abstract Among several lipolytic hormones tested, adrenocorticotropin (ACTH), epinephrine, glucagon, thyroid-stimulating hormone, and luteinizing hormone stimulated adenyl cyclase activity in a plasma membrane-rich fraction, termed ghosts, isolated from rat fat cells. The effects given by various combinations of these hormones, at maximally stimulating concentrations, were not additive, indicating that a single enzyme was activated by all of these hormones. Different effects of the combined hormones were found depending upon the condition of incubation. At 37°, the combined hormones either did not give greater effects or gave smaller effects than that of the most effective hormone. At 30° in the presence of an ATP-regenerating system, each hormone potentiated the effect of the other. The effects on adenyl cyclase activity of combinations of the hormones at concentrations near their apparent Km of activation displayed noncompetitive kinetics. Propranolol, a β receptor antagonist, blocked completely the stimulatory action of epinephrine but did not alter the actions of the peptide hormones. An analogue of ACTH inhibited, specifically and competitively, the stimulatory actions of ACTH both on adenyl cyclase activity in ghosts and on lipolysis in intact fat cells. It was concluded from these findings that the hormones act at discrete hormone-specific sites (or receptors) that affect the activity of a single adenyl adenyl cyclase in fat cells.
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Citations
Cites
Metabolism of Isolated Fat Cells
Rodbell, M. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51687-2 · Cited by 4,427
Self-citationSome Aspects of the Biological Role of Adenosine 3',5'-monophosphate (Cyclic AMP)
SUTHERLAND, E. W., ROBISON, G. A., & BUTCHER, R. W. (1968) · Circulation · doi:10.1161/01.cir.37.2.279 · Cited by 965
Sutherland, E. W., Rall, T. W., & Menon, T. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60312-6 · Cited by 856
ADENYL CYCLASE AS AN ADRENERGIC RECEPTOR*
Robison, G. A., Butcher, R. W., & Sutherland, E. W. (1967) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1967.tb41239.x · Cited by 673
Butcher, R. W., Baird, C. E., & Sutherland, E. W. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93503-9 · Cited by 554
Renal Adenyl Cyclase: Anatomically Separate Sites for Parathyroid Hormone and Vasopressin
Chase, L. R., & Aurbach, G. D. (1968) · Science · doi:10.1126/science.159.3814.545 · Cited by 397
The Cellular Location of Adenyl Cyclase in the Pigeon Erythrocyte
Davoren, P. R., Sutherland, E. W., & Maxwell, A. M. (1963) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51860-3 · Cited by 312
Turtle, J. R., & Kipnis, D. M. (1967) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(67)90388-9 · Cited by 284
Metabolism of Isolated Fat Cells
Rodbell, M., & Jones, A. B. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96968-1 · Cited by 207
Self-citationApplications of Metal Buffers and Metal Indicators in Biochemistry
Raaflaub, J. (1956) · Methods of Biochemical Analysis · doi:10.1002/9780470110195.ch10 · Cited by 162
Cited by
Receptor-effector coupling by G proteins
Birnbaumer, L., Abramowitz, J., & Brown, A. M. (1990) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(90)90007-y · Cited by 1,118
Self-citationAvruch, J., & Hoelzl Wallach, D. F. (1971) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(71)90331-2 · Cited by 828
Freychet, P., Roth, J., & Neville, D. M. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.8.1833 · Cited by 498
The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver
Rodbell, M., Krans, H. M. J., Pohl, S. L., & Birnbaumer, L. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62388-9 · Cited by 473
Self-citationExton, J. H., Robison, G. A., Sutherland, E. W., & Park, C. R. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61771-5 · Cited by 320
Metadata
- Authors
- Birnbaumer, L., & Rodbell, M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1969-07
- Volume
- 244
- Issue
- 13
- Pages
- 3477-3482
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1578024134
- Cited by
- 354
- References
- 15
- FWCI
- 18.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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