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Receptor-coupled, Permeabilized Smooth Muscle
Open accessAbstract
alpha-Adrenergic (phenylephrine) and muscarinic (carbachol) agonists and inositol 1,4,5-trisphosphate caused calcium release and contractions in smooth muscle strips permeabilized with Staphylococcus aureus alpha-toxin. The responses to phenylephrine and carbachol required or were potentiated by added GTP and could be inhibited by GDP beta S. GTP and phenylephrine also increased the contractile response of permeabilized portal vein smooth muscle to cytoplasmic Ca2+. We conclude that while the G-protein-coupled phosphatidylinositol cascade, through inositol 1,4,5-trisphosphate-induced calcium release, is a major mechanism of pharmacomechanical coupling, a second G-protein-mediated pathway that modulates the calcium sensitivity of the regulatory contractile proteins also exists.
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Citations
Cited by
Signal transduction and regulation in smooth muscle
Somlyo, A. P., & Somlyo, A. V. (1994) · Nature · doi:10.1038/372231a0 · Cited by 1,902
Self-citationSignaling Mechanisms Underlying the Vascular Myogenic Response
Davis, M. J., & Hill, M. A. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.2.387 · Cited by 992
Granzier, H. L., & Irving, T. C. (1995) · Biophysical Journal · doi:10.1016/s0006-3495(95)80278-x · Cited by 640
Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.
Hirata, K., Kikuchi, A., Sasaki, T., Kuroda, S., Kaibuchi, K., Matsuura, Y., Seki, H., Saida, K., & Takai, Y. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50337-4 · Cited by 447
Myosin light chain phosphatase: subunit composition, interactions and regulation
Hartshorne, D. J., Ito, M., & Erdo¨di, F. (1998) · Journal of Muscle Research & Cell Motility · doi:10.1023/a:1005385302064 · Cited by 403
Metadata
- Authors
- Kitazawa, T., Kobayashi, S., Horiuti, K., Somlyo, A. V., & Somlyo, A. P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1989-04
- Volume
- 264
- Issue
- 10
- Pages
- 5339-5342
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1507228972
- Cited by
- 427
- References
- 0
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kitazawa, T., Kobayashi, S., Horiuti, K., Somlyo, A. V., & Somlyo, A. P. (1989). Receptor-coupled, Permeabilized Smooth Muscle. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)83550-5
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