The DOI matches its Crossref record; 266 of the 266 references it cites were found in a registry or an index.
Signaling Mechanisms Underlying the Vascular Myogenic Response
Abstract
The vascular myogenic response refers to the acute reaction of a blood vessel to a change in transmural pressure. This response is critically important for the development of resting vascular tone, upon which other control mechanisms exert vasodilator and vasoconstrictor influences. The purpose of this review is to summarize and synthesize information regarding the cellular mechanism(s) underlying the myogenic response in blood vessels, with particular emphasis on arterioles. When necessary, experiments performed on larger blood vessels, visceral smooth muscle, and even striated muscle are cited. Mechanical aspects of myogenic behavior are discussed first, followed by electromechanical coupling mechanisms. Next, mechanotransduction by membrane-bound enzymes and involvement of second messengers, including calcium, are discussed. After this, the roles of the extracellular matrix, integrins, and the smooth muscle cytoskeleton are reviewed, with emphasis on short-term signaling mechanisms. Finally, suggestions are offered for possible future studies.
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Cites
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Mechanotransduction Across the Cell Surface and Through the Cytoskeleton
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Metadata
- Authors
- Davis, M. J., & Hill, M. A.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 1999-04-01
- Volume
- 79
- Issue
- 2
- Pages
- 387-423
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2101722224
- Cited by
- 992
- References
- 266
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
