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Cited by 447

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.

Open access
Hirata, K, Kikuchi, A, Sasaki, T, Kuroda, S, Kaibuchi, K, Matsuura, Y, Seki, H, Saida, K, Takai, Y·1992·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(19)50337-4
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Abstract

In the rabbit mesenteric arterial smooth muscle skinned by saponin, Ca2+ induced contraction in a concentration-dependent manner. Guanosine 5'-(3-O-thio)triphosphate (GTP gamma S), a non-hydrolyzable GTP analogue, lowered the Ca2+ concentrations required for this contraction and increased the Ca2+ sensitivity of the skinned smooth muscle contraction. GTP gamma S alone did not induce the contraction in the absence of Ca2+. This GTP gamma S-enhanced Ca2+ sensitivity was completely abolished by an exoenzyme of Staphylococcus aureus, named EDIN, and an exoenzyme of Clostridium botulinum, named C3, both of which are known to ADP-ribosylate the rho p21 family that belongs to the ras p21-like small GTP-binding protein superfamily. The GTP gamma S-bound form of rhoA p21 overcame the inhibitory action of EDIN. smg p21B, another small GTP-binding protein, was inactive. EDIN ADP-ribosylated a protein, which was most likely to be rho p21, in the skinned smooth muscle. The GTP gamma S-bound form of rhoA p21, but not the GDP-bound form, substituted for GTP gamma S and enhanced the Ca2+ sensitivity of the skinned smooth muscle contraction. smg p21B was inactive. These results indicate that rhoA p21 is involved in the GTP gamma S-enhanced Ca2+ sensitivity of the smooth muscle contraction.

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Metadata

Authors
Hirata, K., Kikuchi, A., Sasaki, T., Kuroda, S., Kaibuchi, K., Matsuura, Y., Seki, H., Saida, K., & Takai, Y.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1992-05
Volume
267
Issue
13
Pages
8719-8722
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(19)50337-4
OpenAlex
W1514066364
Cited by
447
References
30
FWCI
9.16
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction. https://app.cochat.ai/papers/10.1016/s0021-9258(19)50337-4
The paper
Hirata, K., Kikuchi, A., Sasaki, T., Kuroda, S., Kaibuchi, K., Matsuura, Y., Seki, H., Saida, K., & Takai, Y. (1992). Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)50337-4

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.