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THE CREATINE CONTENT OF MUSCLE UNDER NORMAL CONDITIONS. ITS RELATION TO THE URINARY CREATININE
Open accessAbstract
Though an unusual amount of attention has been devoted to urinary creatinine since the introduction of Folin's simple colorimetric method for its estimation in 1904, relatively little consideration has been given to the supposedly related muscle creatine. The few figures which have been published giving the content of muscle creatine have simply served to indicate that the creatine content of vertebrate muscle is in round numbers .4 per cent., though figures for different animals have shown individual results varying from .3-.5 per cent. We have estimated the creatine concentration of muscle in a number of the common laboratory animals, rabbit, dog, cat, guinea pig, monkey, and likewise in man, in a few instances, where we have been able to obtain good samples at autopsy. Our muscle analyses on 20 normal rabbits and 5 dogs have yielded very uniform figures and indicate that the creatine concentration of rabbit muscle is .52 per cent. and of the dog muscle, .37 per cent. Our data on the muscle of the other...
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“Pioneering research in the early 1900’s using animal models showed that creatine supplementation could augment creatine content by 70% [101, 102].”
From Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? (2021) · cites this paper as [102]
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Measurement of muscle mass in humans: validity of the 24-hour urinary creatinine method.
Heymsfield, S., Arteaga, C., McManus, C., Smith, J., & Moffitt, S. (1983) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/37.3.478 · Cited by 902
Antonio, J., Candow, D. G., Forbes, S. C., Gualano, B., Jagim, A. R., Kreider, R. B., Rawson, E. S., Smith-Ryan, A. E., VanDusseldorp, T. A., Willoughby, D. S., et al. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-021-00412-w · Cited by 345
THE HYDROLYSIS OF PHOSPHOCREATINE AND THE ORIGIN OF URINARY CREATININE
Borsook, H., & Dubnoff, J. W. (1947) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30910-9 · Cited by 160
The Nutrition of the Young Ayrshire Calf
Blaxter, K. L., & Howells, A. (1951) · British Journal Of Nutrition · doi:10.1079/bjn19510005 · Cited by 120
Wardlaw, G. M., Hampl, J. S., & DiSilvestro, R. A. (2004) · Cited by 111
Metadata
- Authors
- Myers, V. C., & Fine, M. S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1913-02
- Volume
- 14
- Issue
- 1
- Pages
- 9-26
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W168407574
- Cited by
- 53
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2017: 2 · 2015: 2 · 2014: 1
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Agricultural and Biological Sciences › Food Science › Food Nutrient Composition and Product Development
- Keywords
- creatine, urinary creatinine, creatine metabolism, rabbit muscle, human muscle
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Cite CoChat for the checks on this page, and the paper for its own findings.
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- CoChat. (2026). Citation check: THE CREATINE CONTENT OF MUSCLE UNDER NORMAL CONDITIONS. ITS RELATION TO THE URINARY CREATININE. https://app.cochat.ai/papers/10.1016/s0021-9258(18)88617-3
- The paper
- Myers, V. C., & Fine, M. S. (1913). THE CREATINE CONTENT OF MUSCLE UNDER NORMAL CONDITIONS. ITS RELATION TO THE URINARY CREATININE. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)88617-3
