The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hydroxymethylglutaryl coenzyme A reductase.
Open accessAbstract
Support for the role of a cytosolic oxysterol-binding protein in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase was obtained by correlating the relative binding affinities of a wide range of oxysterols to their potency in suppressing HMG-CoA reductase activity in mouse fibroblast cell cultures. Forty-seven oxysterols encompassing a 100-fold range of activity in both assays were tested and the two parameters were closely correlated for 35 of the sterols. Twelve sterols showed poor binding when compared to their ability to suppress HMG-CoA reductase activity in cell cultures. Among these were seven sterols with a ketone function at C-3. For this group, the discrepancy could be explained by their rapid conversion within cells to the 3 beta-hydroxy derivatives which have a much higher affinity for the binding protein. One sterol with 3-keto-4-ene grouping was not reduced to its 3 beta-hydroxy derivative in cells and thereby showed no discrepancy in the two assays. The remaining five sterols exhibiting discordant activities in the two tests contained 4,4-dimethyl moieties and were relatively weak suppressors of HMG-CoA reductase activity. Cellular metabolism of these sterols was not detected. Possible reasons for their apparent inactivity in the binding assay are discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Biological Activity of Some Oxygenated Sterols
Kandutsch, A. A., Chen, H. W., & Heiniger, H.-J. (1978) · Science · doi:10.1126/science.663671 · Cited by 571
Self-citationKandutsch, A. A., & Chen, H. W. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43148-7 · Cited by 322
Self-citationKandutsch, A. A., & Chen, H. W. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42218-7 · Cited by 283
Self-citationSelf-association of cholesterol in aqueous solution
Haberland, M. E., & Reynolds, J. A. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.8.2313 · Cited by 274
Faust, J. R., Luskey, K. L., Chin, D. J., Goldstein, J. L., & Brown, M. S. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.17.5205 · Cited by 203
Chang, T. Y., & Limanek, J. S. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43901-x · Cited by 165
Inter-relationships between dolichol and sterol synthesis in mammalian cell cultures.
James, M. J., & Kandutsch, A. A. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86911-9 · Cited by 112
Self-citationKandutsch, A. A., & Thompson, E. B. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70380-9 · Cited by 107
Self-citationSinensky, M. S., Torget, R. W., & Edwards, P. A. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68472-3 · Cited by 93
Cited by
Regulation of the mevalonate pathway
Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394
Björkhem, I., Andersson, O., Diczfalusy, U., Sevastik, B., Xiu, R. J., Duan, C., & Lund, E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.18.8592 · Cited by 320
Midzak, A., & Papadopoulos, V. (2014) · Traffic · doi:10.1111/tra.12177 · Cited by 38
Side‐chain specificities of human and bovine cytochromes P‐450scc
TUCKEY, R. C., & CAMERON, K. J. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18235.x · Cited by 38
Bowling, N., Matter, W. F., Gadski, R. A., McClure, D. B., Schreyer, T., Dawson, P. A., & Vlahos, C. J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37462-9 · Cited by 11
Metadata
- Authors
- Taylor, F. R., Saucier, S. E., Shown, E. P., Parish, E. J., & Kandutsch, A. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1984-10
- Volume
- 259
- Issue
- 20
- Pages
- 12382-12387
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1509346516
- Cited by
- 311
- References
- 15
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hydroxymethylglutaryl coenzyme A reductase. https://app.cochat.ai/papers/10.1016/s0021-9258(18)90757-x
- The paper
- Taylor, F. R., Saucier, S. E., Shown, E. P., Parish, E. J., & Kandutsch, A. A. (1984). Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hydroxymethylglutaryl coenzyme A reductase. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)90757-x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
