The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Inhibitors of Protein Biosynthesis
Open accessAbstract
Anisomycin (2-p-methoxyphenylmethyl-3-acetoxy-4-hydroxypyrrolidine) inhibits protein synthesis in HeLa cells, rabbit reticulocytes, Saccharomyces fragilis, and cell-free extracts prepared from these sources, but it is inactive against extracts of Escherichia coli. Partial inhibition of deoxyribonucleic acid synthesis in HeLa cells is observed at anisomycin concentrations which produce 95% inhibition of protein synthesis. These effects on protein and DNA synthesis are rapid in onset and reversible. Anisomycin acts on the transfer reaction subsequent to the formation of aminoacyl transfer ribonucleic acid. In the presence of anisomycin, nascent peptide remains attached to polyribosomes. No derivative of anisomycin that was tested showed more than 1% of the inhibitory activity of the parent compound.
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Cites
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POLYRIBOSOMES IN NORMAL AND POLIOVIRUS-INFECTED HELA CELLS AND THEIR RELATIONSHIP TO MESSENGER-RNA
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Cited by
Contingent Genetic Regulatory Events in T Lymphocyte Activation
Crabtree, G. R. (1989) · Science · doi:10.1126/science.2783497 · Cited by 1,072
Inhibitors of protein synthesis
Vazquez, D. (1974) · FEBS Letters · doi:10.1016/0014-5793(74)80689-7 · Cited by 414
Bordeleau, M.-E., Robert, F., Gerard, B., Lindqvist, L., Chen, S. M. H., Wendel, H.-G., Brem, B., Greger, H., Lowe, S. W., Porco, J. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34753 · Cited by 332
Alpha and Beta Globin Messenger Ribonucleic Acid
Lodish, H. F. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45864-x · Cited by 327
Jack, K., Bellodi, C., Landry, D. M., Niederer, R. O., Meskauskas, A., Musalgaonkar, S., Kopmar, N., Krasnykh, O., Dean, A. M., Thompson, S. R., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.09.017 · Cited by 327
Metadata
- Authors
- Grollman, A. P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1967-07
- Volume
- 242
- Issue
- 13
- Pages
- 3226-3233
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1489055368
- Cited by
- 292
- References
- 25
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
