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An Exonuclease Induced by Bacteriophage λ
Open accessAbstract
λ exonuclease exhibits a much greater rate of attack on native deoxyribonucleic acid than on denatured DNA, the difference in rate being 350-fold for T7 phage DNA. The attack is exclusively exonucleolytic, and the only acid-soluble products are deoxyribonucleoside 5‘-monophosphates. In contrast to the known Escherichia coli exonucleases, its initial site of attack is at the 5‘ termini of a DNA molecule, with a strong preference for termini bearing a phosphoryl residue as compared with those bearing a free hydroxyl group.
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Cited by
Use of Bacteriophage λ Recombination Functions To Promote Gene Replacement in Escherichia coli
Murphy, K. C. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.8.2063-2071.1998 · Cited by 573
Uzbas, F., Opperer, F., Sönmezer, C., Shaposhnikov, D., Sass, S., Krendl, C., Angerer, P., Theis, F. J., Mueller, N. S., & Drukker, M. (2019) · Genome Biology · doi:10.1186/s13059-019-1748-6 · Cited by 23
Newing, T. P., Brewster, J. L., Fitschen, L. J., Bouwer, J. C., Johnston, N. P., Yu, H., & Tolun, G. (2022) · Nature Communications · doi:10.1038/s41467-022-33090-6 · Cited by 22
Metadata
- Authors
- Little, J. W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1967-02
- Volume
- 242
- Issue
- 4
- Pages
- 679-686
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1520987654
- Cited by
- 347
- References
- 0
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Little, J. W. (1967). An Exonuclease Induced by Bacteriophage λ. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)96258-7
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