The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Perhydroxyl radical (HOO.) initiated lipid peroxidation. The role of fatty acid hydroperoxides
Open accessAbstract
It is demonstrated that the perhydroxyl radical (HOO., the conjugate acid of superoxide (O2-], initiates fatty acid peroxidation (a model for biological lipid peroxidation) by two parallel pathways: fatty acid hydroperoxide (LOOH)-independent and LOOH-dependent. Previous workers (Gebicki, J. M., and Bielski, B. H. J. (1981) J. Am. Chem. Soc. 103, 7020-7025) demonstrated that HOO., generated by pulse radiolysis, initiates peroxidation in ethanol/water fatty acid dispersions by abstraction of the bis-allylic hydrogen atom from a polyunsaturated fatty acid. Addition of O2 to the fatty acid radicals forms peroxyl radicals (LOO.s), the chain-propagating species of lipid peroxidation. In this work it is demonstrated that HOO., generated either chemically (KO2) or enzymatically (xanthine oxidase), is a good initiator of fatty acid peroxidation in linoleic acid ethanol/water dispersions; O2- serves only as the source of HOO., and HOO. initiation can be observed at physiologically relevant pH values. In contrast to the previous results, the initiating effectiveness of HOO. is related directly to the initial concentrations of LOOHs in the lipids to be peroxidized. This defines a LOOH-dependent mechanism for fatty acid peroxidation initiation by HOO., which parallels the previously established LOOH-independent pathway. Since the LOOH-dependent pathway is much more facile than the LOOH-independent pathway, LOOH is the kinetically preferred site of HOO. attack in these systems. Experiments comparing HOO./LOOH-dependent fatty acid peroxidation with transition metal- and peroxyl radical-initiated peroxidation rule out the participation of the latter two species as initiators, which defines the HOO./LOOH initiation system as mechanistically unique. LOOH product studies are consistent with either a direct or indirect hydrogen atom transfer between LOOH and HOO. to yield LOO.s, which propagate peroxidation. The LOOH-dependent pathway of HOO.-initiated fatty acid peroxidation may be relevant to mechanisms of lipid peroxidation initiation in vivo.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The superoxide radical is the conjugate base of a weak acid, the hydroperoxide radical HOO•, whose pKa is 4.88 [18].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [18]
In the citing paper
“Superoxide can also become protonated to form the hydroperoxyl radical that can promote lipid peroxidation (7) and subsequent oxidative modification of proteins, low-molecular-weight thiols, and membrane lipids.”
From Redox regulation of mitochondrial function (2012) · cites this paper as [7]
Citations
Cites
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Free Radicals in Biology and Medicine
Land, E. J. (1990) · International Journal of Radiation Biology · doi:10.1080/09553009014552071 · Cited by 4,871
Reactivity of HO2/O− 2 radicals in aqueous solution
Bielski, B. H. J., Cabelli, D. E., Arudi, R. L., & Ross, A. B. (1985) · Journal of Physical and Chemical Reference Data · doi:10.1063/1.555739 · Cited by 2,169
Pryor, W. A. (1976) · Cited by 1,876
Biological effects of the superoxide radical
Fridovich, I. (1986) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(86)90526-6 · Cited by 1,420
Sawyer, D. T., & Valentine, J. S. (1981) · Accounts of Chemical Research · doi:10.1021/ar00072a005 · Cited by 1,365
Oxy-Radicals and Related Species: Their Formation, Lifetimes, and Reactions
Pryor, W. A. (1986) · Annual Review of Physiology · doi:10.1146/annurev.ph.48.030186.003301 · Cited by 1,000
The respiratory burst of phagocytes.
BABIOR, B. M. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111249 · Cited by 902
Carter, P. M. (1971) · Analytical Biochemistry · doi:10.1016/0003-2697(71)90405-2 · Cited by 787
Research works printed but not linked: 7
- Weiss, 1982, Lab. Invest., 47, 5
- Fantone, 1982, Am. J. Pathol., 107, 397
- Milas, 1959, J. Am. Chem. Soc., 81, 3359
- Brawn, 1980, Acta Physiol. Scand., 492, 9
- Chan, 1979, Chem. Phys. Lipids., 24, 245, 10.1016/0009-3084(79)90030-6 · DOI
- Benson, 1971, Vol. 1, 132
- Thomas, 1982, J. Biol. Chem., 257, 8343, 10.1016/S0021-9258(18)34336-9 · DOI
Cited by
Sorted by citations
Items 201–227 of 227
Synthesis of Azulenylsilane Nitrones as Diagnostic Tools for Superoxide Detection
Tamrakar, R. (2011) · FIU - Digital Commons (Florida International University) · doi:10.25148/etd.fi11120906
OXYGEN: FRIEND OR FOE? ARCHAEAL SUPEROXIDE DISMUTASES IN THE PROTECTION OF INTRA- AND
Cannio, R., Fiorentino, G., Morana, A., Rossi, M., & Bartolucci, S. (2000)
Buettner, G. R., Oberley, L. W., Spitz, D. R., & Domann, F. E. (2003)
Ruiz, M. V., & María, J. (2004) · RIUCAM
Kade, I. J. (2008) · Americanae (AECID Library)
Glickman, R. D., & Antonio, S. (2001) · Defense Technical Information Center (DTIC)
EM UM MODELO DE HIPERTIREOIDISMO EXPERIMENTAL
Simon-Giavarotti, K. A. (2001)
Metabolism of Superoxide Radicals and Hydrogen Peroxide in Mitochondria
Marinho, H. S., & Antunes, F. (2015) · Oxidative stress and disease · doi:10.1201/b19420-3
ONE OF THE POSSIBLE MECHANISMS OF GLUCOSE ABSORPTION SLOWING DURING IMMOBILIZATION STRESS
Корытов, Корытов, Л. И., Гребенкина, Grebyonkina, L., Сусликова, & Сусликова, М. И. (2017) · Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук · doi:10.12737/article_590823a4cb2e90.88690054
Marchi, K. C. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2017.tde-19072016-171327
Examination of metabolism in diabetic offspring
Russell, R. (2011) · Louisiana State University · doi:10.31390/gradschool_dissertations.1588
Guerrero, S. J. Á. (2019) · ACI Avances en Ciencias e Ingenierías · doi:10.18272/aci.v11i3.1411
- Mechanisms of Antioxidant Activity
Bartosz, G. (2013) · CRC Press eBooks · doi:10.1201/b15062-16
Therapeutic Modalities Regarding ROS in Leukemia and Hematopoietic Stem/Progenitor Cell Perspective
Law, S., & Ghosh, S. (2021) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-1247-3_91-1
Therapeutic Modalities Regarding ROS in Leukemia and Hematopoietic Stem/Progenitor Cell Perspective
Law, S., & Ghosh, S. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-5422-0_91
Patel, N., Kalen, A. L., Isakov, L., Neuschwander, G., Asha, W., Son, J., Schibler, J., Goswami, P. C., & Sarsour, E. H. (2025) · Radiation Research · doi:10.1667/rade-24-00143.1
Manh, T. D., Bay, M. V., Nhung, N. T. H., Diem, P. M., Truc, N. T. T., Hoa, N. T., Duong, D. V., Binh, N. T. M., & Thong, N. M. (2026) · Chemical Physics · doi:10.1016/j.chemphys.2026.113179
Oxidative stress responses in human fungal pathogens: a review of molecular mechanisms
Pereira, M. D., Costa, L. D. R., Mattos, L. M. M., Pires, D. C., Fonseca, F. L., Santos, A. L. S., & Riger, C. J. (2026) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2026.2706136
Trang, H. T. T., Thuy, P. T., & Ha, N. X. (2026) · Journal of Molecular Modeling · doi:10.1007/s00894-026-06892-4
Metadata
- Authors
- Aikens, J., & Dix, T. A.
- Affiliations
- University of California, Irvine (US)
- ORCID
- Dix, T.A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1991-08
- Volume
- 266
- Issue
- 23
- Pages
- 15091-15098
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1574445997
- Cited by
- 228
- References
- 44
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 8 · 2018: 3 · 2017: 10 · 2016: 9 · 2015: 8 · 2014: 5 · 2013: 11 · 2012: 10
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01gm040338-06)
- National Institute of General Medical Sciences (GM-40338)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- hydroperoxyl radical, lipid peroxidation, fatty acid hydroperoxides, linoleic acid, superoxide, xanthine oxidase, peroxy radicals, hydrogen atom transfer
- MeSH terms
- Chromatography, High Pressure Liquid, Fatty Acids, Free Radicals, Kinetics, Lipid Peroxides, Oxidation-Reduction, Lipid Peroxidation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
