A study of the reactivity of HO2/O2-with unsaturated fatty acids
Open accessAbstract
The reaction of perhydroxyl radical (HO2) with linoleic, linolenic, and arachidonic acids has been studied in aqueous ethanolic solutions by the stopped flow technique. The corresponding rate constants are 1.2 x 10(3), 1.7 x 10(3), and 3.0 x 10(3) M-1 S-1, respectively. While kinetic results suggest that the HO2 radical reacts with the double allylic H atom of the polyunsaturated fatty acids, thermodynamic approximations indicate that the reaction is exothermic by approximately 10 kcal/mol. The relevance of this reaction to membrane damage observed in biological systems that have been exposed to HO2/O2- radicals is discussed.
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Due to its non-ionic nature, the hydroperoxide radical can enter the cell membrane and trigger lipid peroxidation processes.
“Due to its non-ionic nature, it can enter the cell membrane and trigger lipid peroxidation processes [19].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [19]
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- Authors
- Bielski, B. H., Arudi, R. L., & Sutherland, M. W.
- Affiliations
- Brookhaven National Laboratory (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1983-04
- Volume
- 258
- Issue
- 8
- Pages
- 4759-4761
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1486525201
- Cited by
- 546
- References
- 26
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 14 · 2023: 14 · 2022: 13 · 2021: 19 · 2020: 16 · 2019: 22 · 2018: 22 · 2017: 24 · 2016: 20 · 2015: 18 · 2014: 9 · 2013: 15 · 2012: 15
- FWCI
- 20.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01gm023656-14)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- hydroperoxyl radical, superoxide, unsaturated fatty acids, linoleic acid, linolenic acid, arachidonic acid, rate constants, allylic hydrogen abstraction, reaction thermodynamics, membrane damage, lipid peroxidation
- MeSH terms
- Fatty Acids, Unsaturated, Free Radicals, Hydrogen Peroxide, Oleic Acids, Oleic Acid
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