Cited by 546Free Radicals and AntioxidantsAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

A study of the reactivity of HO2/O2-with unsaturated fatty acids

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Bielski, B H, Arudi, R L, Sutherland, M W·1983·Journal of Biological Chemistry

Abstract

The reaction of perhydroxyl radical (HO2) with linoleic, linolenic, and arachidonic acids has been studied in aqueous ethanolic solutions by the stopped flow technique. The corresponding rate constants are 1.2 x 10(3), 1.7 x 10(3), and 3.0 x 10(3) M-1 S-1, respectively. While kinetic results suggest that the HO2 radical reacts with the double allylic H atom of the polyunsaturated fatty acids, thermodynamic approximations indicate that the reaction is exothermic by approximately 10 kcal/mol. The relevance of this reaction to membrane damage observed in biological systems that have been exposed to HO2/O2- radicals is discussed.

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Crossref · 10.1016/s0021-9258(18)32488-8

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Authors
Bielski, B. H., Arudi, R. L., & Sutherland, M. W.
Affiliations
Brookhaven National Laboratory (US)
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1983-04
Volume
258
Issue
8
Pages
4759-4761
ISSN
0021-9258 (ISSN-L)
OpenAlex
W1486525201
Cited by
546
References
26
Citations by year
2026: 10 · 2025: 12 · 2024: 14 · 2023: 14 · 2022: 13 · 2021: 19 · 2020: 16 · 2019: 22 · 2018: 22 · 2017: 24 · 2016: 20 · 2015: 18 · 2014: 9 · 2013: 15 · 2012: 15
FWCI
20.06
Type
journal article
Language
en
Open access
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (5r01gm023656-14)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
hydroperoxyl radical, superoxide, unsaturated fatty acids, linoleic acid, linolenic acid, arachidonic acid, rate constants, allylic hydrogen abstraction, reaction thermodynamics, membrane damage, lipid peroxidation
MeSH terms
Fatty Acids, Unsaturated, Free Radicals, Hydrogen Peroxide, Oleic Acids, Oleic Acid

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