The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice
Open accessAbstract
The human cholesteryl ester transfer protein (CETP) facilitates the exchange of neutral lipids among lipoproteins. In order to evaluate the effects of increased plasma CETP on lipoprotein levels, a human CETP minigene was placed under the control of the mouse metallothionein-I promoter and used to develop transgenic mice. Integration of the human CETP transgene into the mouse genome resulted in the production of active plasma CETP. Zinc induction of CETP transgene expression caused depression of serum cholesterol due to a significant reduction of high density lipoprotein cholesterol. There was no change in total cholesterol content in very low and low density lipoproteins. However, there was a decrease in the free cholesterol/cholesteryl ester ratio in plasma and in all lipoprotein fractions of transgenic mouse plasma, suggesting stimulation of plasma cholesterol esterification. The results suggest that high levels of plasma CETP activity may be a cause of reduced high density lipoproteins in humans.
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Cites
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Cited by
Plasma cholesteryl ester transfer protein
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Self-citationCholesteryl Ester Transfer Protein: A Novel Target for Raising HDL and Inhibiting Atherosclerosis
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Macrophage Reverse Cholesterol Transport: Key to the Regression of Atherosclerosis?
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Metadata
- Authors
- Agellon, L. B., Walsh, A., Hayek, T., Moulin, P., Jiang, X. C., Shelanski, S. A., Breslow, J. L., & Tall, A. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1991-06
- Volume
- 266
- Issue
- 17
- Pages
- 10796-10801
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1626021976
- Cited by
- 298
- References
- 33
- FWCI
- 24.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Agellon, L. B., Walsh, A., Hayek, T., Moulin, P., Jiang, X. C., Shelanski, S. A., Breslow, J. L., & Tall, A. R. (1991). Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)99088-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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