The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol
Open accessAbstract
The interaction of high density lipoproteins (HDL) with the HDL receptor stimulates the translocation of cholesterol from intracellular pools to the plasma membrane where the cholesterol becomes available for removal by appropriate acceptors. The role of signal transduction through protein kinase C in HDL receptor-dependent cholesterol translocation and efflux was examined using cholesterol-loaded cultured human skin fibroblasts. Treatment of cells with HDL3 activated protein kinase C, demonstrated by a transient increase in membrane associated kinase activity. Kinase activation appeared to be dependent on binding of HDL3 to the HDL receptor, since tetranitromethane-modified HDL3, which does not bind to the receptor, was without effect. Translocation of intracellular sterol to the plasma membrane was stimulated by treatment of cells with the protein kinase C activators, dioctanoylglycerol and phorbol myristic acetate, and the calcium ionophore A23187. Conversely, treatment of cells with sphingosine, a protein kinase C inhibitor, reduced HDL3-mediated translocation and efflux of intracellular sterols. However, sphingosine had no effect on efflux of labeled cholesterol derived from the plasma membrane. Down-regulation of cellular protein kinase C activity by long term incubation with phorbol esters also inhibited HDL3-mediated efflux of intracellular sterols and abolished the ability of sphingosine to further inhibit HDL3-mediated efflux. These studies support the conclusion that HDL receptor-mediated translocation and efflux of intracellular cholesterol occurs through activation of protein kinase C.
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Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 317,331
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
Nishizuka, Y. (1988) · Nature · doi:10.1038/334661a0 · Cited by 4,171
Lipid extraction of tissues with a low-toxicity solvent
Hara, A., & Radin, N. S. (1978) · Analytical Biochemistry · doi:10.1016/0003-2697(78)90046-5 · Cited by 2,559
The plasma lecithin:cholesterol acyltransferase reaction
Glomset, J. A. (1968) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43114-1 · Cited by 2,405
LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis
Brown, M. S., & Goldstein, J. L. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.001255 · Cited by 2,300
Bilheimer, D. W., Eisenberg, S., & Levy, R. I. (1972) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(72)90034-3 · Cited by 1,818
Hannun, Y. A., Loomis, C. R., Merrill, A. H., & Bell, R. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67133-9 · Cited by 1,156
Mechanisms and consequences of cellular cholesterol exchange and transfer
Phillips, M. C., Johnson, W. J., & Rothblat, G. H. (1987) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(87)90013-x · Cited by 541
Subfractionation of human high density lipoproteins by heparin-Sepharose affinity chromatography.
Weisgraber, K. H., & Mahley, R. W. (1980) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39811-4 · Cited by 347
Cited by
Molecular physiology of reverse cholesterol transport.
Fielding, C. J., & Fielding, P. E. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39898-9 · Cited by 1,448
Vaisar, T., Pennathur, S., Green, P. S., Gharib, S. A., Hoofnagle, A. N., Cheung, M. C., Byun, J., Vuletic, S., Kassim, S., Singh, P., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci26206 · Cited by 942
Self-citationOram, J. F., & Heinecke, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00005.2005 · Cited by 521
Self-citationBergt, C., Pennathur, S., Fu, X., Byun, J., O'Brien, K., McDonald, T. O., Singh, P., Anantharamaiah, G. M., Chait, A., Brunzell, J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405292101 · Cited by 454
Self-citationIntracellular cholesterol transport
Liscum, L., & Munn, N. J. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00043-8 · Cited by 414
Metadata
- Authors
- Mendez, A. J., Oram, J. F., & Bierman, E. L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1991-06
- Volume
- 266
- Issue
- 16
- Pages
- 10104-10111
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2123151772
- Cited by
- 256
- References
- 38
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Mendez, A. J., Oram, J. F., & Bierman, E. L. (1991). Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)99196-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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