The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Inhibition of receptor-bound urokinase by plasminogen-activator inhibitors.
Open accessAbstract
Urokinase-type plasminogen activator (uPA) binds to a specific receptor on various cell types, the bound molecule retaining its enzymatic activity against plasminogen. We have now investigated whether receptor-bound uPA also retains the ability to react with and be inhibited by plasminogen activator inhibitors (PAI-1 and PAI-2). uPA bound to its receptor on human U937 monocyte-like cells was inhibited by PAI-1 (in its active form in the presence of vitronectin fragments) with an association rate constant of 4.5 x 10(6) M-1 s-1, which was 40% lower than that obtained for uPA in solution (7.9 x 10(6) M-1 s-1). The inhibition of uPA by PAI-2 was decreased to a similar extent by receptor binding, falling from 5.3 x 10(5) to 3.3 x 10(5) M-1 s-1. Stimulation of U937 cells with phorbol 12-myristate 13-acetate was accompanied by a further reduction in receptor-bound uPA inhibition by PAI-1 and PAI-2 to 1.7 x 10(6) and 1.1 x 10(5) M-1 s-1, respectively. These constants although lower than those for uPA in solution still represent rather rapid inhibition of the enzyme, and demonstrate that uPA bound to its specific cellular receptor remains available for efficient inhibition by PAI's, which may therefore play a major role in controlling cell-surface plasminogen activation and extracellular proteolytic activity.
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Cites
Plasminogen Activators, Tissue Degradation, and Cancer
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A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase.
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Autocrine saturation of pro-urokinase receptors on human A431 cells
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Plasminogen Activation Initiated by Single-chain Urokinase-type Plasminogen Activator
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Self-citation
Cited by
Ellis, V., Behrendt, N., & Danø, K. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98963-5 · Cited by 498
Self-citationBlasi, F. (1993) · BioEssays · doi:10.1002/bies.950150206 · Cited by 395
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The plasminogen activator system: biology and regulation
Irigoyen, J. P., Muñoz-Cánoves, P., Montero, L., Koziczak, M., & Nagamine, Y. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000615 · Cited by 368
The urokinase plasminogen activator system: a target for anti-cancer therapy
Ulisse, S., Baldini, E., Sorrenti, S., & D'Armiento, M. (2009) · Current Cancer Drug Targets · doi:10.2174/156800909787314002 · Cited by 312
Metadata
- Authors
- Ellis, V, Wun, T. C., Behrendt, N., Rønne, E., & Danø, K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1990-06
- Volume
- 265
- Issue
- 17
- Pages
- 9904-9908
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1558212310
- Cited by
- 266
- References
- 25
- FWCI
- 13.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ellis, V, Wun, T. C., Behrendt, N., Rønne, E., & Danø, K. (1990). Inhibition of receptor-bound urokinase by plasminogen-activator inhibitors. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)38757-5
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