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Phospholipid synthesis in a membrane fraction associated with mitochondria.

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Vance, J E·1990·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(19)39106-9
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Abstract

A crude rat liver mitochondrial fraction that was capable of the rapid, linked synthesis of phosphatidylserine (PtdSer), phosphatidylethanolamine (PtdEtn), and phosphatidylcholine (PtdCho) labeled from [3-3H] serine has been fractionated. PtdSer synthase, PtdEtn methyltransferase, and CDP-choline:diacylglycerol cholinephosphotransferase activities were present in the crude mitochondrial preparation but were absent from highly purified mitochondria and could be attributed to the presence of a membrane fraction, X. Thus, previous claims of the mitochondrial location of some of these enzymes might be explained by the presence of fraction X in the mitochondrial preparation. Fraction X had many similarities to microsomes except that it sedimented with mitochondria (at 10,000 x g). However, the specific activities of PtdSer synthase and glucose-6-phosphate phosphatase in fraction X were almost twice that of microsomes, and the specific activities of CTP:phosphocholine cytidylyltransferase and NADPH:cytochrome c reductase in fraction X were much lower than in microsomes. The marker enzymes for mitochondria, Golgi apparatus, plasma membrane, lysosomes, and peroxisomes all had low activities in fraction X. Polyacrylamide gel electrophoresis revealed distinct differences, as well as similarities, among the proteins of fraction X, microsomes, and rough and smooth endoplasmic reticulum. The combined mitochondria-fraction X membranes can synthesize PtdSer, PtdEtn, and PtdCho from serine. Thus, fraction X in combination with mitochondria might be responsible for the observed compartmentalization of a serine-labeled pool of phospholipids previously identified (Vance, J. E., and Vance, D. E. (1986) J. Biol. Chem. 261, 4486-4491) and might be involved in the transfer of lipids between the endoplasmic reticulum and mitochondria.

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Metadata

Authors
Vance, J. E.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1990-05
Volume
265
Issue
13
Pages
7248-7256
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(19)39106-9
OpenAlex
W2098329073
Cited by
1,150
References
1
FWCI
6.22
Type
journal article
Language
en
Open access
hybrid
Licence

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CoChat. (2026). Citation check: Phospholipid synthesis in a membrane fraction associated with mitochondria. https://app.cochat.ai/papers/10.1016/s0021-9258(19)39106-9
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Vance, J. E. (1990). Phospholipid synthesis in a membrane fraction associated with mitochondria. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)39106-9

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